Phytotherapeutic Potential of Moringa oleifera: A Comprehensive Review of In-Vitro and In-Vivo Anticancer Mechanisms

References

[1] A. Fahey, “Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1,” Trees for Life Journal, vol. 1, pp. 1–15, 2005.

[2] R. Koul, “Fidel Castro’s moringa revolution,” Cuban Review of Tropical Medicine, vol. 7, no. 3, pp. 15–18, 2010.

[3] TNAU, “PKM 1 and PKM 2 Moringa Varieties,” Tamil Nadu Agricultural University, 2013. [Online]. Available: http://www.tnau.ac.in

[4] L. Fuglie, “The Miracle Tree: The Multiple Attributes of Moringa,” CTA Publications, Wageningen, Netherlands, 2001.

[5] B. Ndabigengesere and K. S. Narasiah, “Quality of water treated by coagulation using Moringa oleifera seeds,” Water Research, vol. 32, no. 3, pp. 781–791, 1998.

[6] C. Lowell and H. Patricia, “Moringa in agroforestry: erosion control and land reclamation,” Agroforestry Today, vol. 9, no. 2, pp. 12–14, 2005.

[7] P. Anwar et al., “Moringa oleifera: a food plant with multiple medicinal uses,” Phytotherapy Research, vol. 21, no. 1, pp. 17–25, 2007.

[8] P. Nandave, N. Ojha, and S. Joshi, “Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats,” International Journal of Pharmacology, vol. 5, pp. 65–72, 2009.

[9] L. Pari and N. Kumar, “Hepatoprotective effect of Moringa oleifera leaf extract against antitubercular drugs-induced liver damage,” Journal of Medicinal Food, vol. 5, no. 3, pp. 171–177, 2002.

[10] S. Mishra, S. Lakhawat, and H. Pandey, "Moringa oleifera: A Miracle Plant," Popular Kheti, vol. 8, no. 2, pp. 29–30, 2020.

[11] D. Newman and G. Cragg, “Natural products as sources of new drugs over the last 25 years,” Journal of Natural Products, vol. 70, no. 3, pp. 461–477, 2007.

[12] B. Wall, “Camptothecin and derivatives,” Cancer Research, vol. 34, pp. 991–1000, 1972.

[13] A. Sinha et al., “Toxicity profile of Moringa oleifera: a systematic review,” Pharmacognosy Reviews, vol. 11, no. 22, pp. 59–66, 2017.

[14] M. Sultana, M. Rahman, and S. Kabir, “Phytochemical and pharmacological profile of Moringa oleifera,” Journal of Natural Medicines, vol. 64, no. 3, pp. 230–240, 2010.

[15] S. Price, “The Moringa Tree,” Echo Technical Note, Florida, USA, 2000.

[16] A. Leone et al., “Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves,” International Journal of Molecular Sciences, vol. 16, no. 6, pp. 12791–12835, 2015.

[17] A. Verma, S. Vijayakumar, C. Mathela, and V. Rao, “In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves,” Food and Chemical Toxicology, vol. 47, no. 9, pp. 2196–2201, 2009.

[18] S. Sreelatha and P. Padma, “Modulatory effects of Moringa oleifera leaf extract on hydrogen peroxide-induced cytotoxicity and oxidative damage,” Environmental Toxicology and Pharmacology, vol. 32, no. 3, pp. 456–465, 2011.

[19] A. Parvathy and S. Umamaheshwari, “Cytotoxic effects of Moringa oleifera on human myeloma cells,” Plant Archives, vol. 7, pp. 79–82, 2007.

[20] S. Nair and V. Varalakshmi, “Anticancer and cytotoxic effects of Moringa oleifera extracts on HeLa cells,” Journal of Natural Remedies, vol. 11, no. 1, pp. 42–47, 2011.

[21] D. Charoensin, “Anticancer and chemopreventive properties of Moringa oleifera leaf extract,” Asian Pacific Journal of Cancer Prevention, vol. 15, pp. 8571–8576, 2014.

[22] F. Khalafalla et al., “Antileukemic activity from Moringa oleifera leaf extracts,” Journal of Ethnopharmacology, vol. 130, no. 1, pp. 107–113, 2010.

[23] I. Jung et al., “Anticancer effects of Moringa oleifera leaf extract on hepatocellular carcinoma cells in vitro and in vivo,” Nutrients, vol. 7, pp. 598–612, 2015.

[24] R. Krishnamurthy et al., “Identification of bioactive fraction with potent anticancer activity from Moringa oleifera leaf,” Biomedicine and Preventive Nutrition, vol. 5, pp. 35–41, 2015.

[25] S. Sreelatha et al., “Antiproliferative and apoptotic effects of Moringa oleifera leaf extract on KB cell line,” Food and Chemical Toxicology, vol. 49, no. 6, pp. 1270–1275, 2011.

[26] A. Tiloke, R. Phulukdaree, and A. Chuturgoon, “Moringa oleifera induces apoptosis in lung cancer cells via ROS, caspase activation and p53 upregulation,” Anticancer Agents in Medicinal Chemistry, vol. 13, no. 8, pp. 1142–1150, 2013.

[27] S. Madi et al., “Cytotoxic and pro-apoptotic effects of Moringa oleifera hot water extract on human cancer cell lines,” PLOS ONE, vol. 11, no. 5, e0154092, 2016.

[28] Z. Berkovich et al., “Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxicity of chemotherapy in pancreatic cancer cells,” BMC Complementary and Alternative Medicine, vol. 13, article 212, 2013.

[29] I. Jung, “Differential cytotoxic effect of Moringa oleifera extract on cancerous and non-cancerous cells,” Journal of Cancer Research and Therapeutics, vol. 10, no. 4, pp. 855–862, 2014.

[30] P. Rao, S. Devi, and D. Rao, “Radioprotective effect of Moringa oleifera leaf extract in Swiss albino mice,” Indian Journal of Experimental Biology, vol. 39, no. 9, pp. 858–863, 2001.

[31] A. Al-Asmari et al., “Moringa oleifera as an anticancer agent against breast and colon cancer cell lines,” PLOS ONE, vol. 10, no. 8, e0135814, 2015.

[32] A. Guevara et al., “Anti-inflammatory and antitumor activities of seed extracts of Moringa oleifera,” Phytotherapy Research, vol. 10, pp. 491–496, 1996.

[33] P. Rajesh et al., “Cytotoxic activity of Moringa oleifera seed extract on human cancer cell lines,” Indian Journal of Experimental Biology, vol. 50, no. 6, pp. 419–425, 2012.

[34] A. Guevara et al., “Isolation and identification of antitumor components from Moringa oleifera seeds,” Phytochemistry, vol. 49, no. 2, pp. 543–549, 1998.

@article{1702747,
      author = {Gaurav Pandey, Mandeep Kumar, Tanmay Singh, Abhinav Rawat},
      title = {Phytotherapeutic Potential of Moringa oleifera: A Comprehensive Review of In-Vitro and In-Vivo Anticancer Mechanisms},
      journal = {Iconic Research And Engineering Journals},
      year = {2021},
      volume = {4},
      number = {11},
      pages = {432-440},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1702747.pdf},
      abstract = {Moringa oleifera, a fast-growing deciduous perennial tree native to the Indian subcontinent and now widely distributed in tropical and subtropical regions, is renowned globally for its multiple uses in nutrition and traditional medicine,?and for its host of environmental and other applications. Well-known for its nourish green?leaves and medicinal properties, the plant has attracted considerable interest over the last years for its potential anticancer capacity. A variety of extracts obtained from different parts of the?moringa tree, especially leaves, were tested on a number of cancer cell lines ? both in vitro and in vivo ? and have shown potential for acting against a broad range of cancer cell types. These extracts show?a remarkable antioxidant, anti-inflammatory, and cytotoxic activity and they can also modulate apoptotic pathways showing a multi-mechanism of action against cancer. This review compiles the latest studies on M. oleifera bioactive compounds and the anticancer action of M. oleifera against experimental models and also?covers some other medicinal properties.},
      keywords = {Moringa oleifera, anticancer activity, apoptosis, phytochemicals, oxidative stress, tumor inhibition},
      month = {May},
  }