International Peer-Reviewed Journal•Open Access•ISSN 2456-8880
irejournals@gmail.com•+91-7433024337

Home / Current Issue / Paper 1702867

1702867 Vol 5 · Issue 1 Download Paper

Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation

Gaurav Pandey Vinay Kumar Varshney Mandeep Kumar Tanmay Singh

Subject area: Physical Sciences and Environment  ·  Area of research: Moringa oleifera Lam.

Abstract

Moringa oleifera Lam., an indegeneous fast growing deciduous tree of the Himalayan foothills in northern India, has received increasing attention for its excellent nutritional?and medicinal characteristics. This tropical species belongs to the Moringaceae family and is full of health-promoting nutrients, protein, vitamin A, important minerals, amino acids and various phenolics including powerful?antioxidants, flavonoids and isothiocyanates. In recent years, its anti-inflammatory, antioxidant, anticarcinogen, hepatoprotectant, neuroprotective, hypoglycemic and hypolipidemic activities have also?been established by scientific studies. These therapeutic effects are mainly attributed to?its wide range of phytochemical contents, particularly flavonoids and isothiocyanates. In this integrative review, we present current scientific reports on the pharmacological effects and their mechanisms of M. oleifera, with special attention to chronic diseases including inflammation-related conditions, diabetes, neuro?degenerative disorders, and cancer. These findings highlight its perspective as a natural remedies long-term care and treatment of some?chronic human diseases.

Keywords

Moringa oleifera, Bioactive phytochemicals, Chronic disease prevention, Anti-inflammatory mechanisms, Antioxidant defense, Nutraceutical therapeutics

References

[1] Anwar, F., Latif, S., Ashraf, M., & Gilani, A.H. (2007). Moringa oleifera: A food plant with multiple medicinal uses. Phytotherapy Research, 21(1), 17–25.

[2] Mahmood, K.T., Mugal, T., & Haq, I.U. (2010). Moringa oleifera: A natural gift—A review. Journal of Pharmaceutical Sciences and Research, 2(11), 775–781.

[3] Abdull, R.A., Ibrahim, M.D., & Kntayya, S.B. (2014). Health benefits of Moringa oleifera. Asian Pacific Journal of Cancer Prevention, 15(20), 8571–8576.

[4] Posmontier, B. (2011). The medicinal qualities of Moringa oleifera. Holistic Nursing Practice, 25(2), 80–87.

[5] Banji, O.J., Banji, D., & Kavitha, R. (2012). Immunomodulatory effects of alcoholic and hydroalcoholic extracts of Moringa oleifera Lam. leaves. Indian Journal of Experimental Biology, 50, 270–276.

[6] S. Mishra, S. Lakhawat, and H. Pandey, "Moringa oleifera: A Miracle Plant," Popular Kheti, vol. 8, no. 2, pp. 29–30, 2020.

[7] Ariel, A., & Serhan, C.N. (2007). Resolvins and protectins in the termination program of acute inflammation. Trends in Immunology, 28(4), 176–183.

[8] Bhatelia, K., Singh, K., & Singh, R. (2014). TLRs: Linking inflammation and breast cancer. Cellular Signalling, 26(11), 2350–2357.

[9] Aggarwal, B.B. (2004). Nuclear factor-kappaB: The enemy within. Cancer Cell, 6(3), 203–208.

[10] Kou, X., Qi, S., Dai, W., Luo, L., & Yin, Z. (2011). Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signaling. International Immunopharmacology, 11(8), 1095–1102.17–23. Refer to original article for detailed inflammation-related studies.

[11] Niedzwiecki, A., et al. (2016). Anticancer efficacy of polyphenols and their combinations. Nutrients, 8(9), 552.

[12] Thapa, A., & Carroll, N.J. (2017). Dietary modulation of oxidative stress in Alzheimer’s disease. International Journal of Molecular Sciences, 18(7), 1583.

[13] Zhang, S.F., et al. (2014). Autophagy-associated targeting pathways of natural products during cancer treatment. Asian Pacific Journal of Cancer Prevention, 15(24), 10557–10563.

[14] Atawodi, S.E., et al. (2010). Evaluation of polyphenol content and antioxidant properties of methanol extracts of Moringa oleifera leaves, stem, and root barks. Journal of Medicinal Food, 13(3), 710–716.

[15] Verma, A.R., et al. (2009). In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves. Food and Chemical Toxicology, 47(9), 2196–2201.

[16] Sreelatha, S., & Padma, P.R. (2009). Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant Foods for Human Nutrition, 64(4), 303–311.30–37. Refer to original article for detailed hepatoprotective studies.

[17] Prince, M., et al. (2013). The global prevalence of dementia: A systematic review and meta-analysis. Alzheimer’s & Dementia, 9(1), 63–75.39–42. See original article for oxidative stress and neurodegeneration studies.

[18] Ganguly, R., & Guha, D. (2008). Protection by Moringa oleifera in a rat model of Alzheimer's disease. Indian Journal of Medical Research, 128, 744–751.

[19] Giacoppo, S., et al. (2017). The isothiocyanate isolated from Moringa oleifera shows potent anti-inflammatory activity in subacute Parkinson’s disease. Rejuvenation Research, 20(1), 50–63.

[20] Hannan, M.A., et al. (2014). Moringa oleifera with neuronal survival and neurite outgrowth promoting potential. Journal of Ethnopharmacology, 152(1), 142–150.

[21] Sutalangka, C., et al. (2013). Moringa oleifera mitigates memory impairment in dementia model. Oxidative Medicine and Cellular Longevity, 2013, 695936.

[22] Ekong, M.B., et al. (2017). Neuroprotective effect of Moringa oleifera against aluminum-induced cortical degeneration. Metabolic Brain Disease, 32(5), 1437–1447.

[23] Kaur, G., et al. (2015). Evaluation of antidepressant activity of Moringa oleifera. Journal of Ayurveda and Integrative Medicine, 6(4), 273–279.

[24] Siegel, R., et al. (2012). Cancer statistics for Hispanics/Latinos, 2012. CA: A Cancer Journal for Clinicians, 62(5), 283–298.

[25] Boggs, D.A., et al. (2010). Fruit and vegetable intake and breast cancer risk. American Journal of Epidemiology, 172(11), 1268–1279.

[26] Fowke, J.H., et al. (2003). Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Research, 63(14), 3980–3986.52–53. See original article for anticancer studies involving Moringa.

[27] Fahey, J.W., et al. (2001). Diversity and distribution of glucosinolates and isothiocyanates. Phytochemistry, 56(1), 5–51.

[28] Xiao, D., et al. (2003). Allyl isothiocyanate inhibits prostate cancer cells. Carcinogenesis, 24(5), 891–897.

[29] Gao, N., et al. (2011). Phenethyl isothiocyanate exhibits antileukemic activity. Cell Death & Disease, 2(4), e140.57–62. Refer to original article for detailed molecular anticancer mechanisms.63–64. General sources on apoptosis and cell cycle arrest in cancer.

[30] Kou, X., et al. (2017). Molecular targets of ampelopsin in cancer prevention. Anti-Cancer Agents in Medicinal Chemistry, 17(12), 1610–1616.

[31] Jafarain, A., et al. (2014). Cytotoxicity of Moringa oleifera extracts on HeLa cells. Advanced Biomedical Research, 3, 194.

[32] Singh, R.P., et al. (2000). Effects of Justicia adhatoda on enzymes and lipid peroxidation. Molecular and Cellular Biochemistry, 213(1–2), 99–109.

[33] Sharma, V., et al. (2012). Chemopreventive efficacy of Moringa pods in carcinogenesis. Asian Pacific Journal of Cancer Prevention, 13(6), 2563–2569.

[34] Bharali, R., et al. (2003). Chemomodulatory effect of Moringa oleifera. Asian Pacific Journal of Cancer Prevention, 4(2), 131–139.

[35] Sharma, V., & Paliwal, R. (2014). Chemoprevention by Moringa saponin against renal cancer. Indian Journal of Clinical Biochemistry, 29(2), 202–209.

[36] Grover, J.K., et al. (2002). Indian medicinal plants with anti-diabetic potential. Journal of Ethnopharmacology, 81(1), 81–100.

[37] Kar, A., et al. (2003). Hypoglycaemic activity of Indian plants in diabetic rats. Journal of Ethnopharmacology, 84(1), 105–108.

[38] Mbikay, M. (2012). Therapeutic potential of Moringa oleifera in hyperglycemia and dyslipidemia. Frontiers in Pharmacology, 3, 24.

[39] Omabe, M., et al. (2014). Ethanolic extract of Moringa in diabetic rats. Journal of Toxicology, 2014, 406242.

[40] Tuorkey, M.J. (2016). Effects of Moringa aqueous extract in diabetic mice. Interventional Medicine & Applied Science, 8(3), 109–117.76–78. See original article for studies on diabetic nephropathy.

[41] Finkel, T., & Holbrook, N.J. (2000). Oxidants, oxidative stress and the biology of aging. Nature, 408(6809), 239–247.

[42] Kou, X., & Chen, N. (2017). Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease. Nutrients, 9(9), 927.

[43] Ganguly, R., & Guha, D. (2008). Alteration of brain monoamines & EEG wave pattern in rat model of Alzheimer's disease & protection by Moringa oleifera. Indian Journal of Medical Research, 128(6), 744–751.

[44] Giacoppo, S., Rajan, T.S., De Nicola, G.R., Iori, R., Rollin, P., Bramanti, P., & Mazzon, E. (2017). The isothiocyanate isolated from Moringa oleifera shows potent anti-inflammatory activity in the treatment of murine subacute Parkinson’s disease. Rejuvenation Research, 20(1), 50–63.

[45] Hannan, M.A., Kang, J.Y., Mohibbullah, M., Hong, Y.K., Lee, H., Choi, J.S., Choi, I.S., & Moon, I.S. (2014). Moringa oleifera with promising neuronal survival and neurite outgrowth promoting potentials. Journal of Ethnopharmacology, 152(1), 142–150.

[46] Sutalangka, C., Wattanathorn, J., Muchimapura, S., & Thukham-mee, W. (2013). Moringa oleifera mitigates memory impairment and neurodegeneration in an animal model of age-related dementia. Oxidative Medicine and Cellular Longevity, 2013, 695936.

[47] Ekong, M.B., Ekpo, M.M., Akpanyung, E.O., & Nwaokonko, D.U. (2017). Neuroprotective effect of Moringa oleifera leaf extract on aluminium-induced temporal cortical degeneration. Metabolic Brain Disease, 32(5), 1437–1447.

[48] Kaur, G., Invally, M., Sanzagiri, R., & Buttar, H.S. (2015). Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine. Journal of Ayurveda and Integrative Medicine, 6(4), 273–279.

[49] Siegel, R., Naishadham, D., & Jemal, A. (2012). Cancer statistics for Hispanics/Latinos, 2012. CA: A Cancer Journal for Clinicians, 62(5), 283–298.

[50] Boggs, D.A., Palmer, J.R., Wise, L.A., Spiegelman, D., Stampfer, M.J., Adams-Campbell, L.L., & Rosenberg, L. (2010). Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. American Journal of Epidemiology,

[51] Fowke, J.H., Chung, F.L., Jin, F., Qi, D., Cai, Q., Conaway, C., Cheng, J.R., Shu, X.O., Gao, Y.T., & Zheng, W. (2003). Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Research, 63(14), 3980–3986.

[52] Al-Asmari, A.K., Albalawi, S.M., Athar, M.T., Khan, A.Q., Al-Shahrani, H., & Islam, M. (2015). Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines. PLoS ONE, 10(8), e0135814.

[53] Berkovich, L., Earon, G., Ron, I., Rimmon, A., Vexler, A., & Lev-Ari, S. (2013). Moringa oleifera aqueous leaf extract down-regulates NF-κB and increases the cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complementary and Alternative Medicine, 13, 212.

[54] Fahey, J.W., Zalcmann, A.T., & Talalay, P. (2001). The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56(1),

[55] Xiao, D., Srivastava, S.K., Lew, K.L., Zeng, Y., Hershberger, P., Johnson, C.S., Trump, D.L., & Singh, S.V. (2003). Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells. Carcinogenesis, 24(5), 891–897.

[56] Gao, N., Budhraja, A., Cheng, S., Liu, E.H., Chen, J., Yang, Z., Chen, D., Zhang, Z., & Shi, X. (2011). Phenethyl isothiocyanate exhibits antileukemic activity by inactivation of Akt and activation of JNK pathways. Cell Death & Disease, 2(4), e140.

[57] Karim, N.A., Ibrahim, M.D., Kntayya, S.B., Rukayadi, Y., Hamid, H.A., & Razis, A.F. (2016). Moringa oleifera Lam: Targeting chemoprevention. Asian Pacific Journal of Cancer Prevention, 17(8), 3675–3686.

[58] Sreelatha, S., Jeyachitra, A., & Padma, P.R. (2011). Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food and Chemical Toxicology, 49(6), 1270–1275.

[59] Waterman, C., Cheng, D.M., Rojas-Silva, P., Poulev, A., Dreifus, J., Lila, M.A., & Raskin, I. (2014). Stable, water-extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry, 103, 114–122.

[60] Jung, I.L. (2014). Soluble extract from Moringa oleifera leaves with a new anticancer activity. PLoS ONE, 9(4), e95492.

[61] Guon, T.E., & Chung, H.S. (2017). Moringa oleifera fruit induces apoptosis via ROS-dependent MAPK activation in human melanoma A2058 cells. Oncology Letters, 14(2), 1703–1710.

[62] Leelawat, S., & Leelawat, K. (2017). Molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants. Oncology Letters, 13(2), 961–966.

[63] Khan, M., Yu, B., Rasul, A., Al, S.A., Yi, F., Yang, H., & Ma, T. (2012). Jaceosidin induces apoptosis in U87 glioblastoma cells through G2/M phase arrest. Evidence-Based Complementary and Alternative Medicine, 2012, 703034.

[64] Khan, M., Zheng, B., Yi, F., Rasul, A., Gu, Z., Li, T., Gao, H., Qazi, J.I., Yang, H., & Ma, T. (2012). Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in U87 glioblastoma cells. Evidence-Based Complementary and Alternative Medicine, 2012, 957568.

[65] Kou, X., Fan, J., & Chen, N. (2017). Potential molecular targets of ampelopsin in prevention and treatment of cancers. Anti-Cancer Agents in Medicinal Chemistry, 17(12), 1610–1616.

[66] Jafarain, A., Asghari, G., & Ghassami, E. (2014). Evaluation of cytotoxicity of Moringa oleifera Lam. callus and leaf extracts on HeLa cells. Advanced Biomedical Research, 3,

[67] Singh, R.P., Padmavathi, B., & Rao, A.R. (2000). Modulatory influence of Justicia adhatoda leaf extract on xenobiotic metabolism enzymes and antioxidant status. Molecular and Cellular Biochemistry, 213(1–2), 99–109.

[68] Sharma, V., Paliwal, R., Janmeda, P., & Sharma, S. (2012). Chemopreventive efficacy of Moringa oleifera pods against DMBA-induced hepatic carcinogenesis in mice. Asian Pacific Journal of Cancer Prevention, 13(6), 2563–2569.

[69] Bharali, R., Tabassum, J., & Azad, M.R. (2003). Chemomodulatory effect of Moringa oleifera on hepatic carcinogen metabolizing enzymes and antioxidant parameters. Asian Pacific Journal of Cancer Prevention, 4(2), 131–139.

[70] Sharma, V., & Paliwal, R. (2014). Potential chemoprevention of DMBA-induced renal carcinogenesis by Moringa oleifera pods and its isolated saponin. Indian Journal of Clinical Biochemistry, 29(2), 202–209.

[71] Grover, J.K., Yadav, S., & Vats, V. (2002). Medicinal plants of India with anti-diabetic potential. Journal of Ethnopharmacology, 81(1), 81–100.

[72] Kar, A., Choudhary, B.K., & Bandyopadhyay, N.G. (2003). Comparative evaluation of hypoglycemic activity of some Indian medicinal plants. Journal of Ethnopharmacology, 84(1), 105–108.

[73] Mbikay, M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Frontiers in Pharmacology, 3, 24.

[74] Omabe, M., Nwudele, C., Omabe, K.N., & Okorocha, A.E. (2014). Anion gap toxicity in alloxan-induced type 2 diabetic rats treated with Moringa oleifera extract. Journal of Toxicology, 2014, 406242.

[75] Tuorkey, M.J. (2016). Effects of Moringa oleifera aqueous leaf extract in alloxan-induced diabetic mice. Interventional Medicine & Applied Science, 8(3), 109–117.

[76] Ndong, M., Uehara, M., Katsumata, S., & Suzuki, K. (2007). Effects of oral administration of Moringa oleifera Lam. on glucose tolerance in Goto-Kakizaki and Wistar rats. Journal of Clinical Biochemistry and Nutrition, 40(3), 229–233.

[77] Omodanisi, E.I., Aboua, Y.G., & Oguntibeju, O.O. (2017). Assessment of the anti-hyperglycaemic and anti-inflammatory activities of Moringa oleifera in a diabetic rat model. Molecules, 22(6), 872.

[78] Adedapo, A.A., Mogbojuri, O.M., & Emikpe, B.O. (2009). Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. Journal of Medicinal Plants Research, 3(8), 586–591.

[79] Mizushima, N., & Komatsu, M. (2011). Autophagy: Renovation of cells and tissues. Cell, 147(4), 728–741.

[80] Levine, B., & Kroemer, G. (2008). Autophagy in the pathogenesis of disease. Cell, 132(1), 27–42.

[81] Deretic, V., Saitoh, T., & Akira, S. (2013). Autophagy in infection, inflammation and immunity. Nature Reviews Immunology, 13(10), 722–737.

[82] Rubinsztein, D.C., Mariño, G., & Kroemer, G. (2011). Autophagy and aging. Cell, 146(5), 682–695.

[83] White, E., Mehnert, J.M., & Chan, C.S. (2015). Autophagy, metabolism, and cancer. Clinical Cancer Research, 21(22), 5037–5046.

[84] Li, J., & Yuan, J. (2008). Caspases in apoptosis and beyond. Oncogene, 27(48), 6194–6206.

How to cite this paper

Gaurav Pandey, Vinay Kumar Varshney, Mandeep Kumar, Tanmay Singh "Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation" Iconic Research And Engineering Journals Volume 5 Issue 1 2021 Page 490-499
Gaurav Pandey, Vinay Kumar Varshney, Mandeep Kumar, Tanmay Singh "Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation" Iconic Research And Engineering Journals, vol. 5, no. 1, Jul. 2021
Gaurav Pandey, Vinay Kumar Varshney, Mandeep Kumar, Tanmay Singh (2021). Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation. Iconic Research And Engineering Journals, 5(1).
Gaurav Pandey, Vinay Kumar Varshney, Mandeep Kumar, Tanmay Singh "Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation" Iconic Research And Engineering Journals, vol. 5, no. 1, Jul. 2021.
@article{1702867,
      author = {Gaurav Pandey, Vinay Kumar Varshney, Mandeep Kumar, Tanmay Singh},
      title = {Therapeutic and Nutraceutical Horizons of Moringa oleifera Lam.: A Comprehensive Review of Bioactive Mechanisms in Chronic Disease Modulation},
      journal = {Iconic Research And Engineering Journals},
      year = {2021},
      volume = {5},
      number = {1},
      pages = {490-499},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1702867.pdf},
      abstract = {Moringa oleifera Lam., an indegeneous fast growing deciduous tree of the Himalayan foothills in northern India, has received increasing attention for its excellent nutritional?and medicinal characteristics. This tropical species belongs to the Moringaceae family and is full of health-promoting nutrients, protein, vitamin A, important minerals, amino acids and various phenolics including powerful?antioxidants, flavonoids and isothiocyanates. In recent years, its anti-inflammatory, antioxidant, anticarcinogen, hepatoprotectant, neuroprotective, hypoglycemic and hypolipidemic activities have also?been established by scientific studies. These therapeutic effects are mainly attributed to?its wide range of phytochemical contents, particularly flavonoids and isothiocyanates. In this integrative review, we present current scientific reports on the pharmacological effects and their mechanisms of M. oleifera, with special attention to chronic diseases including inflammation-related conditions, diabetes, neuro?degenerative disorders, and cancer. These findings highlight its perspective as a natural remedies long-term care and treatment of some?chronic human diseases.},
      keywords = {Moringa oleifera, Bioactive phytochemicals, Chronic disease prevention, Anti-inflammatory mechanisms, Antioxidant defense, Nutraceutical therapeutics},
      month = {July},
  }