Synthesis, Characterization, and Biological Evaluation of Compartmental Thiosemicarbazone Metal Complexes

• Author(s): Dr. N. Y. Badannavar
• Paper ID: 1703636
• Page: 726-736
• Published Date: 31-07-2022
• Published In: Iconic Research And Engineering Journals
• Publisher: IRE Journals
• e-ISSN: 2456-8880
• Volume/Issue: Volume 6 Issue 1 July-2022

Abstract

The research article explores the conceptual design and theoretical implications of thiosemicarbazone ligands as compartmental frameworks capable of coordinating with multiple metal centers simultaneously, focusing on their synthesis through condensation reactions between thiosemicarbazides and aldehydes or ketones to yield ligands with bifunctional or polyfunctional binding sites, their structural characterization using advanced techniques such as X-ray crystallography to reveal coordination geometries, bond lengths, and angles indicative of stable chelation, and their evaluation through computational studies including density functional theory (DFT) to predict electronic distributions and reactivity, emphasizing the role of electronic and steric factors introduced by substituents on the ligand backbone in modulating the coordination environment, while further investigating the catalytic potential of these metal complexes in oxidation and coupling reactions such as the Mizoroki–Heck reaction and their biological activities, with a specific focus on their antimicrobial, anticancer, and antioxidant properties arising from mechanisms like metal-mediated DNA cleavage, generation of reactive oxygen species (ROS), and disruption of enzymatic pathways, supported by theoretical frameworks explaining their activity profiles, along with the limitations posed by solubility, toxicity, and stability issues, which are addressed through theoretical proposals for structural optimizations and the incorporation of advanced delivery systems to enhance their therapeutic and functional applicability, ultimately contributing to a deeper understanding of the coordination chemistry of thiosemicarbazones and their compartmental metal complexes and paving the way for innovative applications in catalysis, material science, and medicinal chemistry.

Keywords

Thiosemicarbazone ligands, Compartmental metal complexes, Coordination chemistry, Advanced structural characterization, Catalytic applications, biological activities

Citations

IRE Journals:
Dr. N. Y. Badannavar "Synthesis, Characterization, and Biological Evaluation of Compartmental Thiosemicarbazone Metal Complexes" Iconic Research And Engineering Journals Volume 6 Issue 1 2022 Page 726-736

IEEE:
Dr. N. Y. Badannavar "Synthesis, Characterization, and Biological Evaluation of Compartmental Thiosemicarbazone Metal Complexes" Iconic Research And Engineering Journals, 6(1)