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Work on Various Methods Used for the Determination of Acid Neutralizing Capacity of Multifarious Antacid Formulations with Their Comparison
Subject area: Science,Engineering and Technology · Area of research: Pharmaceutical Analysis area
Abstract
Acidity is a condition which may be defined as heart burn, formation of gas in stomach due to excess production of stomach acid. Antacids, among other medications, are widely used medicines to reduce the incommodious symptoms of acidity through neutralizing the excess stomach acid. The potency of antacid formulations depends on the Acid Neutralizing Capacity (ANC). However, there is no review work on the methods used for the determination of acid neutralizing capacity of antacid formulations. Therefore, the objectives of the present study are to find out different methods through literature review used for the determination of acid neutralizing capacity of antacid formulations, compare them from different perspectives, and to compile the reported standard specifications for ANC. Besides, another objective is to employ the reported methods to evaluate acid neutralization capacity of an antacid tablet formulation. Reviewed articles include three reported methods viz. pH meter method, back titration method and direct titration method for ANC value determination. The authors of the present review work found from their own experimental study that the pH meter method has some advantages over back titration method such as the pH meter method is cost-effective, easy to carry out, and less time consuming.
Keywords
Acid Neutralizing Capacity, Antacids, Ph Meter Method, Direct Titration Method, Back Titration Method.
How to cite this paper
@article{1704936,
author = {Mossammat Rima Akter, Md. Saddam Hossain, Shomrat Saikh, Md. Nur Alam, Md Rafiquzzaman},
title = {Work on Various Methods Used for the Determination of Acid Neutralizing Capacity of Multifarious Antacid Formulations with Their Comparison},
journal = {Iconic Research And Engineering Journals},
year = {2023},
volume = {7},
number = {4},
pages = {434-445},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1704936.pdf},
abstract = {Acidity is a condition which may be defined as heart burn, formation of gas in stomach due to excess production of stomach acid. Antacids, among other medications, are widely used medicines to reduce the incommodious symptoms of acidity through neutralizing the excess stomach acid. The potency of antacid formulations depends on the Acid Neutralizing Capacity (ANC). However, there is no review work on the methods used for the determination of acid neutralizing capacity of antacid formulations. Therefore, the objectives of the present study are to find out different methods through literature review used for the determination of acid neutralizing capacity of antacid formulations, compare them from different perspectives, and to compile the reported standard specifications for ANC. Besides, another objective is to employ the reported methods to evaluate acid neutralization capacity of an antacid tablet formulation. Reviewed articles include three reported methods viz. pH meter method, back titration method and direct titration method for ANC value determination. The authors of the present review work found from their own experimental study that the pH meter method has some advantages over back titration method such as the pH meter method is cost-effective, easy to carry out, and less time consuming.},
keywords = {Acid Neutralizing Capacity, Antacids, Ph Meter Method, Direct Titration Method, Back Titration Method.},
month = {October},
}