Home / Current Issue / Paper 1704954
Synthesis, Spectroscopic analysis, Antioxidant, and Anti-bacterial activities of (Z)-4-Chloro-N'-(3-methyl-2r,6c-diphenylpiperdin-4-ylidene) benzohydrazides
Subject area: Science,Engineering and Technology · Area of research: Synthetic Organic Chemistry
Abstract
(Z)-4-Chloro-N?-(substituted benzlidenes) benzohydrazides 1(a-e) were blended by abridging 4-Chlorobenzohydrazide with appropriate aldehydes in the molar ratio of 1:1 in the methanol as solvent. For all the synthesized compounds, FT-IR, 1H and 13C NMR spectra have been recorded. The synthesized amalgams were curtained for their anti-oxidant and anti-bacterial activities.
Keywords
Chemical production, Anti-oxidant activity, 4-Chlorobenzhydrazide, NMR spectra
References
[1] S. K. Sahu, B. K. Dubey, A. C. Tripathi, M. Koshy, and S. K. Saraf, Mini Rev. Med. Chem., 2013, 13, 565.
[2] S. Rollas and S. G. Kucukguzel, Molecules, 2007, 17, 1910.
[3] Dar, T. A., Thirunavukkarasu, B., Ganapathi, A., & Jebaraj, J. W. (2022). Chemical synthesis, spectroscopic analysis, antioxidant, and antimicrobial activities of some hydrazones derived from 4-fluorobenzohydrazide. Materials Today: Proceedings, 59, 352-356.
[4] R. Narang, S. Narasimhan and A. Sharma, Curr. Med. Chem., 2012, 19, 569.
[5] C. Sankar and K. Pandiarajan, Eur. J. Med. Chem., 2010, 45, 5480.
[6] M. Valko, D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur and J. Telser, Int. J. Biochem. Cell Biol., 2007, 39, 44.
[7] M. Valko, C. J. Rhodes, J. Moncol, M. Izakovic and M. Mazur, Chem.-Biol. Interact, 2006, 160, 1.
[8] H. V. Harini, J. Kumar, and N. Rangaswamy, Bioorg. Med. Chem. Lett., 2012, 22, 7588.
[9] R. Narang, S. Narasimhan and A. Sharma, Curr. Med. Chem., 2012, 19, 569.
[10] C. Sankar and K. Pandiarajan, Eur. J. Med. Chem., 2010, 45, 5480.
[11] P. Kodisundaram, S. Amirthaganesan and T. Balasankar,J. Agric. Food Chem., 2013, 61, 11952.
[12] S. Y. Ciftci, N. G. Kelekci, U. S. Goksen and G. Ucar, Hacettepe University J. Faculty Pharm., 2011, 31, 27.
[13] H. M. Ali, A. Abo-Shady, H. A. SharafEldeen, H. A. Soror, W. G. Shousha, O. A. Abdel-Barry, and A. M. Saleh, Chem. Central J., 2013, 7, 53.
[14] Dar, T. A., Thirunavukkarasu, B., Ganapathi, A., & Jebaraj, W. (2022). New hydrazones bearing fluoro-benzohydrazide scaffold: synthesis, characterization, molecular docking study, and anti-oxidant investigations. Materials Today: Proceedings, 66, 2387-2392.
[15] G. Rajitha, N. Saideepa, and P. Praneetha, Indian J. Chem., 2011, 50, 729.
[16] K. Inami, Y. Iizuka, M. Furukawa, I. Nakanishi, K. Ohkubo,K. Fukuhara, S. Fukuzumi and M. Mochizuki, Bioorg. Med. Chem., 2012, 20, 4049.
[17] M. Valko, D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur and J. Telser, Int. J. Biochem. Cell Biol., 2007, 39, 44.
[18] M. Valko, C. J. Rhodes, J. Moncol, M. Izakovic and M. Mazur, Chem.-Biol. Interact, 2006, 160, 1.
[19] C. R. Noller and V. Baliah, J. Am. Chem. Soc., 1948, 70, 3853.
[20] Thirunavukkarasu, B. Synthesis, Spectroscopic Analysis, Molecular Docking, Anti-Oxidant, and Anti-Microbial Activities of Novel (E)-4-fluoro-N'-(3-methyl-2r, 6c-diphenylpiperdin-4-ylidene) benzohydrazides.
[21] B.A. Ashwar, A. Gani, I.A.Wani, A. Shah, F.A. Masoodi, D.C. Saxena, Production of resistant starch from rice by dual auto claving retrogradation treatment: in vitro digestibility, thermal and structural characterization, Food Hydrocoll. 56 (2017)108–117.
[22] A. Shah, M. Ahmad, B.A. Ashwar, A. Gani, F.A. Masoodi, I.A.Wani, S.M.Wani, A. Gani, Effect of γ-irradiation on structure and neutraceutical potential of β-D-glucan from barley (Hordeum vulgare), Int. J. Biol. Macromol. 72 (2015) 1168–1175.
[23] Dar, K. A., Senthilmurugan, S., Ali, S., Al-Sadoon, M. K., & Paray, B. A. (2022). Studies on the isolation and identification of the antibacterial compound from Prunella vulgaris L. Flower extract. Journal of King Saud University-Science, 34(8), 102324.
How to cite this paper
@article{1704954,
author = {Tanzeer Ahmad Dar, Balasankar Thirunavukkarasu, Khursheed Ahmad Dar, Aadil Farooq Shah, Kawsar Jan},
title = {Synthesis, Spectroscopic analysis, Antioxidant, and Anti-bacterial activities of (Z)-4-Chloro-N'-(3-methyl-2r,6c-diphenylpiperdin-4-ylidene) benzohydrazides},
journal = {Iconic Research And Engineering Journals},
year = {2023},
volume = {7},
number = {2},
pages = {116-122},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1704954.pdf},
abstract = {(Z)-4-Chloro-N?-(substituted benzlidenes) benzohydrazides 1(a-e) were blended by abridging 4-Chlorobenzohydrazide with appropriate aldehydes in the molar ratio of 1:1 in the methanol as solvent. For all the synthesized compounds, FT-IR, 1H and 13C NMR spectra have been recorded. The synthesized amalgams were curtained for their anti-oxidant and anti-bacterial activities.},
keywords = {Chemical production, Anti-oxidant activity, 4-Chlorobenzhydrazide, NMR spectra},
month = {August},
}