Recent Advancements in Trifluoroethylation Reactions: New Methods and Applications in Organic Synthesis

• Author(s): Dr. K. S. Lamani
• Paper ID: 1705020
• Page: 826-834
• Published Date: 30-09-2023
• Published In: Iconic Research And Engineering Journals
• Publisher: IRE Journals
• e-ISSN: 2456-8880
• Volume/Issue: Volume 7 Issue 3 September-2023

Abstract

This paper provides an overview of recent advancements in trifluoroethylation reactions, emphasizing their growing significance in organic synthesis due to the unique properties of the trifluoroethyl group, which imparts chemical stability, lipophilicity, and electron-withdrawing effects that enhance the biological and physicochemical properties of target molecules; the review discusses novel methods developed for introducing the trifluoroethyl group into organic molecules, including transition metal-catalyzed processes, nucleophilic substitution reactions, and photochemical methods, highlighting the mechanistic insights behind these transformations and their efficiency in selective trifluoroethylation at diverse positions on substrates, including aromatic and aliphatic compounds; key advances in the field, such as the development of highly selective reagents and the optimization of reaction conditions to minimize side reactions, are presented, alongside a discussion of the role of catalytic systems that facilitate these reactions under mild conditions, promoting sustainability in organic synthesis; the broader applications of trifluoroethylation in medicinal chemistry, materials science, and agrochemicals are also explored, with examples of the incorporation of the trifluoroethyl group in bioactive molecules, enhancing their pharmacokinetic properties, and in the design of novel materials with improved electronic and optical properties, alongside the synthesis of trifluoroethylated agrochemicals that exhibit enhanced stability and effectiveness; the paper concludes with a forward-looking perspective on the potential future directions in the field, such as the development of greener and more efficient catalytic methods, the expansion of trifluoroethylation to more complex and sterically hindered substrates, and the exploration of new applications in drug discovery and sustainable chemical processes, while acknowledging the challenges in scaling up reactions for industrial applications and overcoming the limited availability of trifluoroethylating reagents.

Keywords

Trifluoroethylation, Organic Synthesis, Transition Metal Catalysis, Medicinal Chemistry, Materials Science, Catalytic Methods

Citations

IRE Journals:
Dr. K. S. Lamani "Recent Advancements in Trifluoroethylation Reactions: New Methods and Applications in Organic Synthesis" Iconic Research And Engineering Journals Volume 7 Issue 3 2023 Page 826-834

IEEE:
Dr. K. S. Lamani "Recent Advancements in Trifluoroethylation Reactions: New Methods and Applications in Organic Synthesis" Iconic Research And Engineering Journals, 7(3)