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Effect of Coffee Beans Towards Conversion of Blood Group B to Blood Group O
Subject area: Biological & Medical Sciences · Area of research: Pharmacology
Abstract
ABO and RhD variants are the most studied blood groups . ABO incompatible blood transfusions are one of the leading causes of harmful and even fatal transfusion reactions. To prevent this, a universally transfusable blood group has to be created. Progressions are being made towards the modification of blood group B to blood group O. This can be done by removing the antigens from the RBC surface and converting it to universal blood group and this idea was pioneered by Goldstein and colleagues at the New York Blood Center in the early 1980s. The conversion of group B RBCs to O was carried out using ?-galactosidase extracted from coffee beans especially Coffea arabica and Coffea canephora. However, because this enzyme ha poor kinetic properties and low pH optimum, the process was not economically viable but clinical trials showed positive results. The ECO-RBC product can be characterized by various methods like blood group serology, SDS PAGE Western blot, flow cytometry, ELISA etc. Presently, safety and efficacy of ECO RBCs are evaluated by performing more clinical trials.
Keywords
Transfusion reactions,?-galactosidase, Coffea arabica, Coffea canephora, ECO RBC
References
[1] iflscience.com/scientists-edge-closer-being-able-change-blood-types-28090
[2] Olsson, M. L., Hill, C. A., De La Vega, H., Liu, Q. P., Stroud, M. R., Valdinocci, J., ... & Kruskall, M. S. (2004). Universal red blood cells—enzymatic conversion of blood group A and B antigens. Transfusion clinique et biologique, 11(1), 33-39.
[3] Zhang, Yang-pei, Feng Gong, Guo-qiang Bao, Hong-wei Gao, Shou-ping Ji, Ying-xia Tan, Su-bo Li et al. "B to O erythrocyteconversion by the recombinant ±-galactosidase." Chinese medical journal 120, no. 13 (2007): 1145-1150.
[4] Praveen Kumar Vemuri et al. Effect of Arabica and Canephora coffee bean extracts towards modification of red blood cell surface antigens. Int. Res. J. Pharm. 2018;9(5):91-95
[5] Rahfeld, Peter, and Stephen G. Withers. "Toward universal donor blood: Enzymatic conversion of A and B to O type." Journal of Biological Chemistry 295, no. 2 (2020): 325-334.
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123567/
[7] https://www.medicalnewstoday.com/articles/324077#what-is-hydroxycut
[8] https://www.redcrossblood.org/
[9] [Some characters in this reference could not be displayed correctly — please refer to the published PDF for the full reference.]
How to cite this paper
@article{1705222,
author = {Ch. Lochana, K. Alekhya, G. Prerana, M. Moulika, B. Srilatha; S. Sivasarthika},
title = {Effect of Coffee Beans Towards Conversion of Blood Group B to Blood Group O},
journal = {Iconic Research And Engineering Journals},
year = {2023},
volume = {7},
number = {5},
pages = {228-231},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1705222.pdf},
abstract = {ABO and RhD variants are the most studied blood groups . ABO incompatible blood transfusions are one of the leading causes of harmful and even fatal transfusion reactions. To prevent this, a universally transfusable blood group has to be created. Progressions are being made towards the modification of blood group B to blood group O. This can be done by removing the antigens from the RBC surface and converting it to universal blood group and this idea was pioneered by Goldstein and colleagues at the New York Blood Center in the early 1980s. The conversion of group B RBCs to O was carried out using ?-galactosidase extracted from coffee beans especially Coffea arabica and Coffea canephora. However, because this enzyme ha poor kinetic properties and low pH optimum, the process was not economically viable but clinical trials showed positive results. The ECO-RBC product can be characterized by various methods like blood group serology, SDS PAGE Western blot, flow cytometry, ELISA etc. Presently, safety and efficacy of ECO RBCs are evaluated by performing more clinical trials.},
keywords = {Transfusion reactions,?-galactosidase, Coffea arabica, Coffea canephora, ECO RBC},
month = {November},
}