Comparative Studies of the Effects of Three Topical Anaesthetics on Tear Quality and Tear Quantity

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@article{1706367,
      author = {Chioma Lucy Enagbare},
      title = {Comparative Studies of the Effects of Three Topical Anaesthetics on Tear Quality and Tear Quantity},
      journal = {Iconic Research And Engineering Journals},
      year = {2024},
      volume = {8},
      number = {4},
      pages = {70-84},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/17063671.pdf},
      abstract = {Purpose: This study compared the effects of three different topical anaesthetics agents on tear quantity and tear   quality.
Methods: To establish this, 51 healthy subjects aged 18 ? 35 years with mean age of 20.02?1.82 years who do not have any ocular diseases were used. The study sample consisted of 25 males and 26 females of the University of Benin, Nigeria. The tear quantity and quality were measured for each subject before and after instillation of each topical anaesthetic agents. The anaesthetics used were 2% Lidocaine hydrochloride, 0.5% Proparacaine hydrochloride and 0.5% Tetracaine hydrochloride. Schirmer's tear test was used to assess the quantity of tears while tear quality was assessed with the Non-Invasive Tear Break-Up-Time (NIBUT).
Results: The result obtained showed that 0.5% Proparacaine hydrochloride had a statistically significant decrease in tear quantity produced after its instillation, using the one-way analysis of variance, ANOVA (F = 6.930, P< 0.05). 0.5% Proparacaine hydrochloride also had a statistically significant decrease on tear film stability time (F = 5.071,P< 0.05) while 2% Lidocaine hydrochloride had the least effect on tear quantity and 0.5% Tetracaine hydrochloride had the least effect on tear quality.
Conclusion: It was discovered that of these three topical anaesthetic agents, 0.5% tetracaine hydrochloride may be the preferred choice in optometric practice particularly in patients with evaporative dry eye while 2% Lidocaine will be the drug of choice particularly in patients with aqueous deficient dry eye. The use of proparacaine should be discouraged in patients with dry eye syndrome to avoid more complications.
},
      keywords = {Anaesthetics, Non-Invasive Tear Break-Up Time, Schirmer?s test, Dry eye Disease, Proparacaine, Lidocaine, tetracaine.},
      month = {October},
  }