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A.I- Driven Predictive Analytics in Managing Exacerbation Risks in Chronic Respiratory Disease Patients
Subject area: Science,Engineering and Technology · Area of research: Healthcare and Artificial Intelligence
Abstract
Chronic respiratory diseases (CRDs), including asthma and chronic obstructive pulmonary disease (COPD), present significant global health challenges due to their high prevalence, complex management requirements, and susceptibility to acute exacerbations. Traditional approaches to managing these conditions rely on reactive measures, resulting in suboptimal patient outcomes and escalating healthcare costs. This paper explores the transformative potential of artificial intelligence (AI)-driven predictive analytics in reshaping CRD management. By leveraging diverse datasets encompassing genetic predispositions, environmental exposures, and lifestyle variables, AI models can predict exacerbation risks with unprecedented accuracy, enabling timely and personalized interventions. The study highlights key components of predictive analytics, including the integration of genetic markers, pollution levels, and behavioral factors, and discusses their implications for risk stratification and proactive care. Furthermore, it examines the technical, ethical, and privacy-related challenges that must be addressed to ensure equitable and secure deployment of these technologies. Reviewing current research, the paper emphasizes how AI-driven models can optimize treatment plans, enhance patient adherence, and significantly reduce hospitalizations and associated costs. This work also identifies future directions for advancing AI in CRD management, emphasizing the need for more stringent algorithms, real-time health monitoring integration, and interdisciplinary collaboration. By embracing these innovations, the healthcare system can transition toward a more proactive, patient-centered, and cost-effective paradigm for managing chronic respiratory diseases.
Keywords
Chronic Respiratory Diseases (CRDs), Asthma, Chronic Obstructive Pulmonary Disease (COPD), Artificial Intelligence (AI), Predictive Analytics, Exacerbation Risk Prediction, Proactive Healthcare, Personalized Medicine, Machine Learning Models, Genetic Markers, Environmental Factors, Lifestyle Variables, Healthcare Cost Reduction, Real-time Health Monitoring, Ethical Considerations
References
[1] Ahmad Z. Al Meslamani (2023) How AI is advancing asthma management? Insights into economic and clinical aspects, Journal of Medical Economics, 26:1, 1489-1494, DOI: 10.1080/13696998.2023.2277072
[2] Aliferis, C., Simon, G. (2024). Overfitting, Underfitting, and General Model Overconfidence and Under-Performance Pitfalls and Best Practices in Machine Learning and AI. In: Simon, G.J., Aliferis, C. (eds) Artificial Intelligence and Machine Learning in Health Care and Medical Sciences. Health Informatics. Springer, Cham. https://doi.org/10.1007/978-3-031-39355-6_10
[3] Aliyu, Dahiru Adamu & Akashah, Eme & Yahaya, Saidu & Adamu, Shamsuddeen & Umar, Kabir & Abubakar Bunu, Sadiq & Mamman, Hussaini. (2024). Optimization Techniques for Asthma Exacerbation Prediction Models: A Systematic Literature Review. IEEE Access. PP. 1-1. 10.1109/ACCESS.2024.3440502.
[4] Almuhanna, H., Alenezi, M., Abualhasan, M., Alajmi, S., Alfadhli, R., & Karar, A. S. (2024). AI Asthma Guard: Predictive Wearable Technology for Asthma Management in Vulnerable Populations. Applied System Innovation, 7(5), 78. https://doi.org/10.3390/asi7050078
[5] Alwarith J, Kahleova H, Crosby L, Brooks A, Brandon L, Levin SM, Barnard ND. The role of nutrition in asthma prevention and treatment. Nutr Rev. 2020 Nov 1;78(11):928-938. doi: 10.1093/nutrient/nuaa005. PMID: 32167552; PMCID: PMC7550896.
[6] Anneclaire J. De Roos, James P. Senter, Leah H. Schinasi, Wanyu Huang, Kari Moore, Mitchell Maltenfort, Christopher Forrest, Sarah E. Henrickson, Chén C. Kenyon. (2024). Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children. Journal of Allergy and Clinical Immunology: Global. https://doi.org/10.1016/j.jacig.2024.100248.
[7] Arora A, Alderman JE, Palmer J, Ganapathi S, Laws E, McCradden MD, Oakden-Rayner L, Pfohl SR, Ghassemi M, McKay F, Treanor D, Rostamzadeh N, Mateen B, Gath J, Adebajo AO, Kuku S, Matin R, Heller K, Sapey E, Sebire NJ, Cole-Lewis H, Calvert M, Denniston A, Liu X. (2023). The value of standards for health datasets in artificial intelligence-based applications. Nat Med. 2023 Nov;29(11):2929-2938. doi: 10.1038/s41591-023-02608-w. Epub 2023 Oct 26. PMID: 37884627; PMCID: PMC10667100.
[8] Azad, Tashin & Islam, Md. (2024). Health Data Analytics and Predictive Modeling: Exploring how advanced data analytics and predictive modeling can enhance decision-making in healthcare management, improve patient outcomes, and optimize resource allocation. 11. 10.5281/zenodo.11485543.
[9] Brommels, Mats. (2020). Patient Segmentation: Adjust the Production Logic to the Medical Knowledge Applied and the Patient's Ability to Self-Manage—A Discussion Paper. Frontiers in Public Health. 8. 195. 10.3389/fpubh.2020.00195.
[10] Dixon D, Sattar H, Moros N, Kesireddy SR, Ahsan H, Lakkimsetti M, Fatima M, Doshi D, Sadhu K, Junaid Hassan M. Unveiling the Influence of AI Predictive Analytics on Patient Outcomes: A Comprehensive Narrative Review. Cureus. 2024 May 9;16(5):e59954. doi: 10.7759/cureus.59954. PMID: 38854327; PMCID: PMC11161909.
[11] Dixit, Pankaj & Taqa, Amer. (2023). Transfer Learning in Image Recognition: Leveraging Pre-trained Models for Improved Performance. 2. 2583-9993.
[12] Doctoroff L, Herzig SJ. Predicting Patients at Risk for Prolonged Hospital Stays. Med Care. 2020 Sep;58(9):778-784. doi: 10.1097/MLR.0000000000001345. PMID: 32826743; PMCID: PMC7444462.
[13] Foil KE. Variants of SERPINA1 and the increasing complexity of testing for alpha-1 antitrypsin deficiency. Ther Adv Chronic Dis. 2021 Jul 29;12_suppl:20406223211015954. doi: 10.1177/20406223211015954. PMID: 34408833; PMCID: PMC8367212.
[14] Gabriella Brancaccio, Anna Balato, Josep Malvehy, Susana Puig, Giuseppe Argenziano, Harald Kittler. (2024).Artificial Intelligence in Skin Cancer Diagnosis: A Reality Check. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2023.10.004.
[15] Gaceja KV, Ancheta ZFR, Buna ACA, Clarencio SMS, Garrido MAR, Ramos JDA. (2023). Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis. Asia Pac Allergy. 2023 Dec;13(4):148-157. doi: 10.5415/apallergy.0000000000000119. Epub 2023 Oct 9. PMID: 38094093; PMCID: PMC10715742.
[16] Gala D, Behl H, Shah M, Makaryus AN. The Role of Artificial Intelligence in Improving Patient Outcomes and Future of Healthcare Delivery in Cardiology: A Narrative Review of the Literature. Healthcare (Basel). 2024 Feb 16;12(4):481. doi: 10.3390/healthcare12040481. PMID: 38391856; PMCID: PMC10887513.
[17] Graña-Castro, O., Izquierdo, E., Piñas-Mesa, A., Menasalvas, E., & Chivato-Pérez, T. (2024). Assessing the Impact of New Technologies on Managing Chronic Respiratory Diseases. Journal of Clinical Medicine, 13(22), 6913. https://doi.org/10.3390/jcm13226913
[18] Hakizimana A, Devani P, Gaillard EA. (2024). Current technological advancement in asthma care. Expert Rev Respir Med. 2024 Jul;18(7):499-512. doi: 10.1080/17476348.2024.2380067. Epub 2024 Jul 17. PMID: 38992946.
[19] Hasan Zafari, Sarah Langlois, Farhana Zulkernine, Leanne Kosowan, Alexander Singer. (2022).AI in predicting COPD in the Canadian population. Biosystems. https://doi.org/10.1016/j.biosystems.2021.104585.
[20] Hwang, Hyemin & Jang, Jae-Hyuk & Lee, Eunyoung & Park, Hae-Sim & Lee, Jae. (2023). Prediction of the number of asthma patients using environmental factors based on deep learning algorithms. Respiratory Research. 24. 10.1186/s12931-023-02616-x
[21] Jessica Good, (2024). Researchers Develop Way To Provide Asthma Attack Early Warnings. allas.edu/social-sciences/early-warning-asthma-attacks-2024/
[22] John R. Hurst, Neil Skolnik, Gerald J. Hansen, Antonio Anzueto, Gavin C. Donaldson, Mark T. Dransfield, Precil Varghese (2020). Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life. European Journal of Internal Medicine. https://doi.org/10.1016/j.ejim.2019.12.014.
[23] Kiseleva A, Kotzinos D, De Hert P. (2022) Transparency of AI in Healthcare as a Multilayered System of Accountabilities: Between Legal Requirements and Technical Limitations. Front Artif Intell. 2022 May 30;5:879603. doi: 10.3389/frai.2022.879603. PMID: 35707765; PMCID: PMC9189302.
[24] Krishnan Narasimhan, (2020). Difficult-to-Treat and Severe Asthma: Management Strategies. https://www.aafp.org/pubs/afp/issues/2021/0301/p286.html#:~:text=2-,Up%20to%2017%25%20of%20asthma%20cases%20are%20classified%20as%20difficult,of%20these%20are%20considered%20severe.&text=Severe%20asthma%20accounts%20for%20up,of%20the%20cost%20of%20asthma.&text=The%20costs%20for%20individuals%20with,for%20individuals%20with%20mild%20asthma.
[25] Kumar, Deepak & Pawar, Priyanka & Gonaygunta, Hari & Nadella, Geeta & Meduri, Karthik & Singh, Shoumya. (2024). Machine learning's role in personalized medicine & treatment optimization. World Journal of Advanced Research and Reviews. 2. 1675-1686. 10.30574/wjarr.2024.21.2.0641.
[26] Li, Z., Huang, K., Liu, L. et al. Early detection of COPD based on graph convolutional network and small and weakly labeled data. Med Biol Eng Comput 60, 2321–2333 (2022). https://doi.org/10.1007/s11517-022-02589-x
[27] Lotfata, A., Moosazadeh, M., Helbich, M. et al. (2023). Socioeconomic and environmental determinants of asthma prevalence: a cross-sectional study at the U.S. County level using geographically weighted random forests. Int J Health Geogr 22, 18 (2023). https://doi.org/10.1186/s12942-023-00343-6
[28] Lugogo NL, DiPietro M, Reich M, Merchant R, Chrystyn H, Pleasants R, Granovsky L, Li T, Hill T, Brown RW, Safioti G. A Predictive Machine Learning Tool for Asthma Exacerbations: Results from a 12-Week, Open-Label Study Using an Electronic Multi-Dose Dry Powder Inhaler with Integrated Sensors. J Asthma Allergy. 2022 Nov 11;15:1623-1637. doi: 10.2147/JAA.S377631. PMID: 36387836; PMCID: PMC9664923.
[29] Luo G, He S, Stone BL, Nkoy FL, Johnson MD. (2020). Developing a Model to Predict Hospital Encounters for Asthma in Asthmatic Patients: Secondary Analysis. JMIR Med Inform doi: 10.2196/16080
[30] Mahsa Khoramipour, Amir Jalali, Bahareh Abbasi, Mohammad Hadi Abbasian. (2023). Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2023.110707.
[31] Molfino NA, Turcatel G, Riskin D. Machine Learning Approaches to Predict Asthma Exacerbations: A Narrative Review. Adv Ther. 2024 Feb;41(2):534-552. doi: 10.1007/s12325-023-02743-3. Epub 2023 Dec 19. PMID: 38110652; PMCID: PMC10838858.
[32] Montesinos López, O.A., Montesinos López, A., Crossa, J. (2022). Overfitting, Model Tuning, and Evaluation of Prediction Performance. In: Multivariate Statistical Machine Learning Methods for Genomic Prediction. Springer, Cham. https://doi.org/10.1007/978-3-030-89010-0_4
[33] National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs; Committee on Women in Science, Engineering, and Medicine; Committee on Improving the Representation of Women and Underrepresented Minorities in Clinical Trials and Research; Bibbins-Domingo K, Helman A, editors. Improving Representation in Clinical Trials and Research: Building Research Equity for Women and Underrepresented Groups. Washington (DC): National Academies Press (US); 2022 May 17. 4, Barriers to Representation of Underrepresented and Excluded Populations in Clinical Research.Available from: https://www.ncbi.nlm.nih.gov/books/NBK584407/
[34] Nugroho, Heru. (2023). A Review: Data Quality Problem in Predictive Analytics. IJAIT (International Journal of Applied Information Technology). 7. 79. 10.25124/ijait.v7i02.5980.
[35] Prachayakul Tulachom, Jumnean Wongsrikaeo, Toansakul T. Santiboon, Gregory S. Alexander. (2024). INTERACTIONS WITH POPULACES’ PERCEPTIONS OF THE POLICY FOR SOLVING PROBLEMS OF THE PM2.5 DUST TOXIC POLLUTION ON HEALTH AND THE IMPACT CONTAMINATION TO AFFECTED RESPIRATORY SYSTEM DISEASES. European Journal of Public Health Studies. DOI: 10.46827/ejphs.v7i3.193
[36] Qinfeng Zhou, Junxiong Ma, Shyam Biswal, Nicholas R. Rowan, Nyall R. London, Charles A. Riley, Stella E. Lee, Jayant M. Pinto, Omar G. Ahmed, Mintao Su, Zhisheng Liang, Runming Du, Murugappan Ramanathan Jr., Zhenyu Zhang. (2024). Air pollution, genetic factors, and chronic rhinosinusitis: A prospective study in the UK Biobank. Science of The Total Environment. https://doi.org/10.1016/j.scitotenv.2024.173526.
[37] Quint JK, Ariel A, Barnes PJ. Rational use of inhaled corticosteroids for the treatment of COPD. NPJ Prim Care Respir Med. 2023 Jul 24;33(1):27. doi: 10.1038/s41533-023-00347-6. PMID: 37488104; PMCID: PMC10366209.
[38] Rockenschaub P, Hilbert A, Kossen T, Elbers P, von Dincklage F, Madai VI, Frey D. 2024. The Impact of Multi-Institution Datasets on the Generalizability of Machine Learning Prediction Models in the ICU. Crit Care Med. 2024 Nov 1;52(11):1710-1721. doi: 10.1097/CCM.0000000000006359. Epub 2024 Jul 3. PMID: 38958568; PMCID: PMC11469625.
[39] Sagheb E, Wi CI, Yoon J, Seol HY, Shrestha P, Ryu E, Park M, Yawn B, Liu H, Homme J, Juhn Y, Sohn S. Artificial Intelligence Assesses Clinicians' Adherence to Asthma Guidelines Using Electronic Health Records. J Allergy Clin Immunol Pract. 2022 Apr;10(4):1047-1056.e1. doi: 10.1016/j.jaip.2021.11.004. Epub 2021 Nov 17. PMID: 34800704; PMCID: PMC9007821.
[40] Shang, Y., Jiang, K., Wang, L. et al. The 30-day hospital readmission risk in diabetic patients: predictive modeling with machine learning classifiers. BMC Med Inform Decis Mak 21 (Suppl 2), 57 (2021). https://doi.org/10.1186/s12911-021-01423-y
[41] Siddiqui, H. -U. -R., Raza, A., Saleem, A. A., Rustam, F., Díez, I. d. l. T., Aray, D. G., Lipari, V., Ashraf, I., & Dudley, S. (2023). An Approach to Detect Chronic Obstructive Pulmonary Disease Using UWB Radar-Based Temporal and Spectral Features. Diagnostics, 13(6), 1096. https://doi.org/10.3390/diagnostics13061096
[42] Steve Alder (2024). Healthcare Data Breach Statistics. HIPAA Journal. https://www.hipaajournal.com/healthcare-data-breach-statistics/#
[43] Susanne J. van de Hei, Boudewijn J.H. Dierick, Joyce E.P. Aarts, Janwillem W.H. Kocks, Job F.M. van Boven. (2021). Personalized Medication Adherence Management in Asthma and Chronic Obstructive Pulmonary Disease: A Review of Effective Interventions and Development of a Practical Adherence Toolkit. The Journal of Allergy and Clinical Immunology: In Practice. https://doi.org/10.1016/j.jaip.2021.05.025.
[44] Tiotiu AI, Novakova P, Nedeva D, Chong-Neto HJ, Novakova S, Steiropoulos P, Kowal K. (2020). Impact of Air Pollution on Asthma Outcomes. Int J Environ Res Public Health. 2020 Aug 27;17(17):6212. doi: 10.3390/ijerph17176212. PMID: 32867076; PMCID: PMC7503605.
[45] Tsvetanov, F. (2024). Integrating AI Technologies into Remote Monitoring Patient Systems. Engineering Proceedings, 70(1), 54. https://doi.org/10.3390/engproc2024070054
[46] Urroz Guerrero PD, Oliveira JM, Lewthwaite H, Gibson PG, McDonald VM. Key Considerations When Addressing Physical Inactivity and Sedentary Behaviour in People with Asthma. J Clin Med. 2023 Sep 15;12(18):5998. doi: 10.3390/jcm12185998. PMID: 37762938; PMCID: PMC10531510.
[47] Wang L, Li G, Ezeana CF, Ogunti R, Puppala M, He T, Yu X, Wong SSY, Yin Z, Roberts AW, Nezamabadi A, Xu P, Frost A, Jackson RE, Wong STC. (2022). An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients. Sci Rep. 2022 Nov 30;12(1):20633. doi: 10.1038/s41598-022-22434-3. PMID: 36450795; PMCID: PMC9712389.
[48] Xiong S, Chen W, Jia X, Jia Y, Liu C. Machine learning for prediction of asthma exacerbations among asthmatic patients: a systematic review and meta-analysis. BMC Pulm Med. 2023 Jul 28;23(1):278. doi: 10.1186/s12890-023-02570-w. PMID: 37507662; PMCID: PMC10386701.
[49] Youming Zhang. (2023). From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMB. Chinese Medical Journal Pulmonary and Critical Care Medicine. https://doi.org/10.1016/j.pccm.2023.08.001.
[50] Zab Mosenifar. (2024). Chronic Obstructive Pulmonary Disease (COPD). https://emedicine.medscape.com/article/297664-overview?form=fpf
[51] John M. James, (2024). Asthma Facts and Figures. https://aafa.org/asthma/asthma-facts/
How to cite this paper
@article{1706664,
author = {Oluwatobi Anthonia Ogunfuye},
title = {A.I- Driven Predictive Analytics in Managing Exacerbation Risks in Chronic Respiratory Disease Patients},
journal = {Iconic Research And Engineering Journals},
year = {2024},
volume = {8},
number = {6},
pages = {339-348},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1706664.pdf},
abstract = {Chronic respiratory diseases (CRDs), including asthma and chronic obstructive pulmonary disease (COPD), present significant global health challenges due to their high prevalence, complex management requirements, and susceptibility to acute exacerbations. Traditional approaches to managing these conditions rely on reactive measures, resulting in suboptimal patient outcomes and escalating healthcare costs. This paper explores the transformative potential of artificial intelligence (AI)-driven predictive analytics in reshaping CRD management. By leveraging diverse datasets encompassing genetic predispositions, environmental exposures, and lifestyle variables, AI models can predict exacerbation risks with unprecedented accuracy, enabling timely and personalized interventions. The study highlights key components of predictive analytics, including the integration of genetic markers, pollution levels, and behavioral factors, and discusses their implications for risk stratification and proactive care. Furthermore, it examines the technical, ethical, and privacy-related challenges that must be addressed to ensure equitable and secure deployment of these technologies. Reviewing current research, the paper emphasizes how AI-driven models can optimize treatment plans, enhance patient adherence, and significantly reduce hospitalizations and associated costs. This work also identifies future directions for advancing AI in CRD management, emphasizing the need for more stringent algorithms, real-time health monitoring integration, and interdisciplinary collaboration. By embracing these innovations, the healthcare system can transition toward a more proactive, patient-centered, and cost-effective paradigm for managing chronic respiratory diseases.},
keywords = {Chronic Respiratory Diseases (CRDs), Asthma, Chronic Obstructive Pulmonary Disease (COPD), Artificial Intelligence (AI), Predictive Analytics, Exacerbation Risk Prediction, Proactive Healthcare, Personalized Medicine, Machine Learning Models, Genetic Markers, Environmental Factors, Lifestyle Variables, Healthcare Cost Reduction, Real-time Health Monitoring, Ethical Considerations},
month = {December},
}