Particle Size Distribution & Zeta Potential of Solid- Lipid Nanoparticles Emulsion

References

[1] M. J. Mycek, R. A. Harvey and P. C. Champe, Pharmacology, Lippincott Williams & Wilkins, Philadelphia, P.A., 2000.

[2] Yongtao D.A., Abhishek D.B., Chetan P. C., Mehul K.C., Swarnali N.B., Prolay S.B., Nadavala S.K., Rohit L.V. A brief review on Solid-Lipid nanoparticles: part and parcel of contemporary drug delivery system. Published on the 21st of July, 2020 by the Royal Society of Chemistry. DOI:10.1039/dora03491f

[3] S. C. Yang, L. F. Lu, Y. Cai, J. B. Zhu, B. W. Liang and C. Z. Yang, J. Controlled Release, 1999, 59(3), 299–307.

[4] Pardeike, J.; Hommoss, A.; Müller, R.H. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int. J. Pharm. 2009, 366, 170–184.

[5] Amasya G., Aksu B., Badilli U., Onay-Besikci A., Tarimci N. QbD guided early pharmaceutical development study: Production of lipid nanoparticles by high pressure homogenization for skin cancer treatment. Int. J. Pharm. 2019; 563:110– 121. doi: 10.1016/j.ijpharm.2019.03.056

[6] Duan Y., Dhar A., Patel C., Khimani M., Neogi S., Sharma P., Siva Kumar N., Vekariya R.L. A brief review on solid lipid nanoparticles: Part and parcel of contemporary drug delivery systems. RSC Adv. 2020; 10:26777–26791. doi: 10.1039/D0RA03491

[7] Liu, J.; Hu, W.; Chen, H.; Ni, Q.; Xu, H.; Yang, X. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int. J. Pharm. 2007, 328, 191– 195.

[8] Mcclements, D.J. Crystals and crystallization in oil-in-water emulsions: Implications for emulsion-based delivery systems. Adv. Colloid Inter. Sci. 2012, 174, 1–30. [Google Scholar] [CrossRef]

[9] RSTcd“”•–—˜ §ñ ò Å Æ ëøŠŒŽªöéÞÔÞË¿°¤¤•ƒoWoWoWWWWooE"hÓ+ÏhÓ+Ï5�6�CJOJQJaJ.hÓ+Ïhƒ5�6�CJOJPJQJaJmH sH &hÓ+ÏhÓ+Ï5�6�CJOJPJQJaJ"hÓ+Ïh^~ 5�6�CJOJQJaJh^~ h˜gCJOJQJaJh^~ CJOJQJaJh^~ h=°CJOJQJaJh^~ h^~ 6�OJQJhƒ6�OJQJhÓ+ÏOJPJQJh^~ h^~ OJQJh^~ h^~ CJOJQJhƒCJ(OJQJSTd•–—˜ŒŽPRlnµñäÏÅ°žž””””}””$ &F„7„Éý¤^„7`„Éýa$gdÓ+Ïm$ $¤a$gdÓ+Ï„ñÿ„ dð¤]„ñÿ^„ gd^~ $„ñÿ„ dð¤]„ñÿ^„ a$gd^~ $¤a$gdÓ+Ï$„`„öÿdë¤^„``„öÿa$gd˜g$dð¤a$gd^~ [Some characters in this reference could not be displayed correctly — please refer to the published PDF for the full reference.]

[10] Æ´¤a$gd­3<ªNPRjlnö4±´µ¶îﶶîÚȶ¤‹oooooo\FF000*hÓ+Ïh7ÎCJOJQJ\�]�aJmH sH *hÓ+ÏhƒCJOJQJ\�]�aJmH sH $hÓ+ÏCJOJQJ\�]�aJmH sH 6hÓ+Ïhnt¢CJOJPJQJ\�]�aJmH nH sH tH 0hÓ+ÏCJOJPJQJ\�]�aJmH nH sH tH "hÓ+Ïh˜gCJOJQJ\�]�aJ"hÓ+Ïh^~ CJOJQJ\�]�aJ"hÓ+ÏhƒCJOJQJ\�]�aJ&hÓ+Ïh^~ CJOJPJQJ\�]�aJ"hÓ+Ïhƒ5�6�CJOJQJaJµ¶ï“”¥¦§¨ãäk‚ ¿ØCo•–åæõõõõõõõõëõõõõÖÖÖÖÖÖÖÌÌõ $¤a$gd*BÏ$ &F„„äþ¤^„`„äþa$gdÓ+Ï $¤a$gdÓ+Ï $¤a$gdÓ+Ï’“” ¤¥¦§¨©”¥¦§¨âãä9E—§ô ääËä¯ää™™iiSii@iiiiii$hÓ+ÏCJOJQJ\�]�aJmH sH +jhÓ+ÏhƒCJOJQJU\�]�aJ*hÓ+ÏhƒCJOJQJ\�]�aJmH sH 3jhÓ+ÏhƒCJOJQJU\�]�aJmH sH *hÓ+Ïh7ÎCJOJQJ\�]�aJmH sH 6hÓ+ÏhJOÖCJOJPJQJ\�]�aJmH nH sH tH 0hÓ+ÏCJOJPJQJ\�]�aJmH nH sH tH 6hÓ+Ïh7ÎCJOJPJQJ\�]�aJmH nH sH tH efÁÉjk�‚Ÿ ¾¿×Ø0BCno”•–’“”•–äåê×êêê×êÁêêêêêêêêêêêêêêêê§ê§�wêêa*hÓ+ÏhdCJOJQJ\�]�aJmH sH +jhÓ+ÏhƒCJOJQJU\�]�aJ3j]ehÓ+ÏhƒCJOJQJU\�]�aJmH sH 3jhÓ+ÏhƒCJOJQJU\�]�aJmH sH *hÓ+ÏhJOÖCJOJQJ\�]�aJmH sH $hÓ+ÏCJOJQJ\�]�aJmH sH *hÓ+ÏhƒCJOJQJ\�]�aJmH sH åæ—žñOPQ£° í×Á×Á×®˜~×~dN×××í×8×Á*hÓ+ÏhdCJOJQJ\�]�aJmH sH +jhÓ+ÏhƒCJOJQJU\�]�aJ3júhÓ+ÏhdCJOJQJU\�]�aJmH sH 3jhÓ+ÏhƒCJOJQJU\�]�aJmH sH *hÓ+Ïh*BÏCJOJQJ\�]�aJmH sH $hƒCJOJQJ\�]�aJmH sH *hÓ+ÏhK{fCJOJQJ\�]�aJmH sH *hÓ+ÏhƒCJOJQJ\�]�aJmH sH $h*BÏCJOJQJ\�]�aJmH sH æPQÿ ""»"¼"S$T$ [Some characters in this reference could not be displayed correctly — please refer to the published PDF for the full reference.]

@article{1707166,
      author = {Adeola Adenitan},
      title = {Particle Size Distribution & Zeta Potential of Solid- Lipid Nanoparticles Emulsion},
      journal = {Iconic Research And Engineering Journals},
      year = {2025},
      volume = {8},
      number = {8},
      pages = {266-271},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1707166.pdf},
      abstract = {Solid lipid nanoparticles are at the forefront of the quickly expanding field of nanotechnology because of their numerous potentials uses in clinical treatment, research, drug delivery, and other diverse fields. The distinct size-dependent characteristics of solid-lipid nanoparticles present an opportunity to create novel therapies.  This experiment was carried out to determine the particle size distribution and the zeta potential of two type of emulsion made using 1g of SLN particles (Ibuprofen/Tristearin/Poloxamer 40) at a ratio 10/20/70.  The samples were made into an emulsion measuring 1g of SLN using Ibuprofen/ Tristearin/Poloxamer 407 in the ratio of 10/20/70 by homogenising using an Ultra Turraz K25 Homogeniser at 15,000rpm for 3mins and the other sample using an Ultrasonic Processor at 100% amplitude of 7watts for 1min.  Emulsion made using the ultrasonic processor had a better zeta potential of -0.0036v, poly dispersity index of 28.5% and a hydrodynamic DM of 1.2600?m, which means a better stable emulsion as compared to sample made with ultra-homogeniser having a zeta potential of - 0.0008v, poly dispersity index (PDI) of 56% and a hydrodynamic DM of 22.996?m.},
      keywords = {Solid-lipid nanoparticles, Zeta-potentials, emulsions, Particle size distribution},
      month = {February},
  }