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Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria

Appah Matthew Omomoni Ochu Abdulmajeed Okene Doutimi Tebekaemi Akpoufuoma Oghenetega Friday Toby David Timipere

Subject area: Physical Sciences and Environment  ·  Area of research: Environmental, Geology

Abstract

The contamination of alcoholic beverages with heavy metals poses serious public health concerns, particularly when their concentrations exceed safe limits established by regulatory bodies such as the World Health Organization (WHO). This study evaluates the toxicological profile of heavy metals in locally produced dry gin from Ogbia Local Government Area, Bayelsa State, Nigeria, and assesses the associated health risks. Thirty (30) gin samples were collected from production centers in Atubu Creek-Onuebum and analyzed using Atomic Absorption Spectrophotometry (AAS) to determine the concentrations of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), nickel (Ni), zinc (Zn), and lead (Pb). The results revealed significant concentrations of As (1.553 ? 0.101 ?g/mL), Hg (1.683 ? 0.209 ?g/mL), Pb (3.123 ? 0.25 ?g/mL), Cu (0.240 ? 0.002 ?g/mL), and Mn (0.613 ? 0.05 ?g/mL). Comparing these values with WHO permissible limits for drinking water and alcoholic beverages, the concentrations of As (0.01 ?g/mL), Hg (0.006 ?g/mL), and Pb (0.01 ?g/mL) were found to be significantly higher in the gin samples, indicating potential health risks such as neurotoxicity, organ damage, and carcinogenic effects. While Cu and Mn were detected within WHO safe limits (2.0 ?g/mL for Cu and 0.5 ?g/mL for Mn), their presence in alcoholic beverages still raises concerns due to the potential for bioaccumulation. Other metals, including Cd, Co, Cr, Ni, and Zn, were detected at trace levels but remained below WHO limits. The high concentrations of heavy metals in local dry gin may be attributed to contamination from raw materials, production techniques, and storage conditions. Given these findings, urgent regulatory intervention, public sensitization, and stricter enforcement of production standards are necessary to mitigate heavy metal exposure from local alcoholic beverages.

Keywords

Heavy metals, local dry gin, toxicological assessment, WHO limits, health risks, Ogbia LGA, Atomic Absorption Spectrophotometry (AAS).

References

[1] Aiyeloja, A. T. Oladele, O. & Tumulo, N. (2014). Potentials of Raffia hookeri Wine in Livelihood Sustenanceamong Rural and Urban Populations in Nigeria. International Journal of Social, Behavioral, Educational, Economic, Business and Industrial Engineering, 8(7), pp. 2325-2332.

[2] Alfonso-Loeches, S. Pascual-Lucas, M. Blanco, A.M. Sanchez-Vera, I., & Guerri, C. (2010). Pivotal role of TLR4 Receptors in alcohol-induced neuroinflammation and brain damage. J. Neurosci., 30(24), 8285-8295.

[3] Alvira- Martin, F. Pautas de consumo de bebidas alcohólicas entre los jóvenes Españoles. Ministerio de Sanidad y Consumo. Madrid; 1982. 220 p.

[4] American Academy of Pediatrics. Uso y abuso del alcohol: una preocupación pediátrica. Pediatrics (ed. esp.) 1995; 39:188-92.

[5] Ashraf, S. Abbas, F. Ibrahim, M. Rashid, U. Khalid, S. Ahmad, H.R. Hakeem, K.R.; & Majeed, T. (2015) J Geog Sci 25:2

[6] Azab, Y.A. Mandour, R.A. Ibrahim,W. Kenawy, I. El-Menshawy, A., & El-Zyat, M. Chemical evaluation of some heavy metals in surface drinking water in Dakahlyia Governorate and warning from their toxicity. Mansoura. J. Forensic Med. Clin. Toxicol. 2010, 2, 69–80.

[7] Braza-Boïls, A. Tomás, M. Marín, M.P. Megías L. Sancho-Tello, M. Fornas, E., & Renau-Piqueras, J. (2006). Glycosylation is altered by ethanol in rat hippocampal cultured neurons. Alcohol Alcohol, 41(5), 494-504.

[8] Brook, M. Walfish, S. Stenmark D., & Canger, J. Personality variables in alcohol abuse in college students. J Drug Educ. 1981; 11:185-9.

[9] Buglass, A.J. (2011) Handbook of Alcoholic Beverages: Technical, Analytical and Nutritional Aspects. 2 Volume Set (John Wiley & Sons Ltd) pp 1208. Assessed 5 Nov 2021

[10] Chowdhury, P. & Gupta, P. (2006). Pathophysiology of alcoholic pancreatitis: An overview. World J. Gastroenterol, 12(46), 7421-7427.

[11] Collins, S.E. & Kirouac, M. (2013) Encyclopaedia of Behavioural Medicine. NY Springer, New York, pp 61–65.

[12] Damsere-Derry, J. Afukaar, F. Palk, G.; & King, M. Determinants of drink driving and association between drink-driving and road traffic fatalities in Ghana, Int. J. Alcohol. Drug Res. 3 (2014) 135–141.

[13] Deitrich, R. Zimatkin, S., & Pronko, S. (2006). Oxidation of ethanol in the brain and its consequences. Alcohol Res. Health, 29(29), 266-273.

[14] Deka, A.K. Handique, P., & Deka, D.C (2021) Toxicology Reports 8(2021):1220–1225. https:// doi. org/ 10. 1016/j. toxrep. 2021. 06.013

[15] Deka, A.K. Handique, P.; & Deka, D.C. (2021) Toxicology Reports 8(2021):1220–1225. https:// doi. org/ 10. 1016/j. toxrep. 2021. 06. 013 59. OIV.

[16] Dibofori-Orji, A.N. & Ali, S.T. (2019). Physicochemical analysis of palm wine. Journal of Pharmacognosy and Phytochemistry, 8(1), pp. 417-421.

[17] Dimelu, M. U. Agbo, C.; & Igbokwe, E. M. (2011). Pattern of alcohol consumption and its effects on livelihood in selected rural communities of Enugu state, Nigeria. Asian Journal of Agriculture and Rural Development, 1(2), pp.69-79.

[18] Egoro, E. T. Ilegbedion, G. I.; & Zebedee, U. L. 2018. Toxic Effects of Chronic Consumption of Ogogoro (Local Gin): A Biochemical and Haematological Study in Some Male Consumers in Ajegunle Nigeria; Global Journal of Medical Research, 18 (6).

[19] Erah, P.O. Akujieze, C.N., & Oteze, G.E. The Quality of groundwater in Benin City: A baseline study on inorganic chemicals and microbial contaminants of health importance in boreholes and open wells. Trop. J. Pharm. Res. 2002, 1, 75–82.

[20] Fratiglioni, L. Ahlbom, A. Viitanen, M., & Winblad, B. (1993). Risk factors for late-onset Alzheimer's disease: A population-based, case-control study. Ann. Neuroi., 33(3), 258-266.

[21] Freund, G. & Ballinger, W.E. Jr. (1992). Alzheimer's disease and alcoholism: Possible interactions. Alcohol, 9(3), 233-240.

[22] Garba, Z.N. Ubam, S. Babando, A.A., & Galadima, A. Quantitative Assessment of Heavy Metals from Selected Tea Brands Marketed in Zaria, Nigeria. J. Phys. Sci. 2015, 26, 43–51.

[23] Gaur, D.S. Talekar, M.S., & Pathak, V.P. (2010). Alcohol intake and cigarette smoking impact of two major lifestyle factors on male fertility. Ind. J. Pathol. Microbiol., 53(1), 35-40.

[24] Griswold, M.G. Fullman, N. Hawley, C. Arian, N. Zimsen, S.R.M Tymeson, H.D. Venkateswaran, V. Tapp, A.D. Forouzanfar, M.H.

[25] Grodstein, F. Goldman, M.B., & Cramer, D.W. (1994). Infertility in women and moderate alcohol use. Am. J. Public Health, 84(9), 1429-1432.

[26] Grover, S. Mattoo, S.K. Pendharkar, S., & Kandappan, V. (2014). Sexual dysfunction in patients with alcohol and opioid dependence. Ind. J. Psycholog. Med., 36(4), 355-365.

[27] Gude, D. (2012). Alcohol and fertility. J. Human Reprod. Sci., 5(2), 226-227.

[28] Gutiahr, E. Gmel, G., & Rehm, J. Relation betwin average alcohol consumption and disease: an overview. Eur Addict Res. 2001; 7(3):117-27.

[29] Hashimoto, T. Ueha T. Kuriyama T. Katsura, M., & Kuriyama, K. (1989). Acetaldehyde-induced alterations in metabolism of monoamines in mouse brain. Alcohol Alcohol., 24, 91-99.

[30] Hillbom, M. Pieninkeroinen, I., & Leone, M. (2003).Seizures in alcohol-dependent patients. CNS Drugs, 17(14), 1013-1030.

[31] Hingson, R.W. Heeren, T., & Winter, M.R. Age at drinking onset and alcohol dependence: Age at onset, duration, and severity. Arch Pediatr Adolesc Med. 2006; 160(7):739-46.

[32] Hunt, W. A. (1996). Role of acetaldehyde in the actions of ethanol on the brain: A review. Alcohol, 13, 147-151.

[33] IARC (2010). International agency for Research on Cancer (IARC) (2010). International Agency for Researchon Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans. 96, Alcoholic Beverage Consumption and Ethyl Carbamate (Urethane).

[34] Idonije O.B Festus, O.O, Asika, E.C. Ilegbusi, M.I.; & Okhiai, O. 2012. A Comparative Biochemical Analysis of Local Gin (Ogogoro) from Different Parts of Nigeria and Imported Gin (Dry Gin) - Toxicogenic, Carcinogenic and Socio-political Implications. Science Journal of Medicine and Clinical Trials, 179:4.

[35] Idonije, O.B. Festus, O.O. Asika, E.C.A. Ilegbusi M.I.; & Okhiai O. (2012). A Comparative Biochemical Analysis of Local Gin (Ogogoro) from Different Parts of Nigeria and Imported Gin (Dry Gin) - Toxicogenic, Carcinogenic and Sociopolitical Implications. Science Journal of Medicine and Clinical Trials, 2012, pp.1-4.

[36] Ikegwu, J. U. (2014). The value of palm wine tapping in the food production practices of Igbo-land: a case study of Idemili South Local Government Area, Anambra State. Journal of Research on Humanities and Social Sciences, 4(6), pp. 49-54.

[37] Iweala, E.E.J. Olugbuyiro, J.A.O. Durodola, B.M. Fubara-Manuel, D.R.; & Okoli, A.O. (2014) Research Journal of Environmental Toxicology. https:// doi. org/ 10. 3923/ rjet. 2014. 92. 97. https:// scial ert. net/ abstr act/? doi= rjet. 2014. 92. 97

[38] Iweala, E.E.J. Olugbuyiro, J.A.O. Durodola, B.M. Fubara-Manuel, D.R., & Okoli, A.O. Metal contamination of foods and drinks consumed in Ota, Nigeria. Res. J. Environ. Toxicol. 2014, 8, 92–97.

[39] Iwegbue, C.M. Ojelum, A.L.; & Bassey, F.I. 2014. A survey of metal profiles in some traditional alcoholic beverages in Nigeria. Food Sci Nutr. 2 (6):724-33.

[40] Iwegbue, C.M.A. Nwozo, S.O. Overah, C.L. Bassey, F.I., & Nwajei, G.E. Concentrations of Selected Metals IN Some Ready-to-Eat-Foods Consumed in Southern Nigeria: Estimation of Dietary Intakes and Target Hazard Quotients. Turk. J. Agric. Food Sci. Technol. 2013, 1, 1–7.

[41] Izah, S.C. Chakrabarty, N., & Srivastav, A.L. A Review on Heavy Metal Concentration in PotableWater Sources in Nigeria: Human Health Effects and Mitigating Measures. Exp. Health 2016, 8, 285–304.

[42] Izah, S.C. Chakrabarty, N., & Srivastav, A.L.A (2015). Review on heavy metal concentration in potable water sources in Nigeria: Human health effects and mitigating measures of experimental health. Journal Environmental Biology 28(8), 285-304.

[43] Jarup, L. (2003). Hazards of heavy metal contamination. British Medical Bulletin, 6(8), 167-182.

[44] Jensen, T.K. Hjollun, N.H.I. Henriksen, T.B. Scheike, T. Kolstad, H. Giwercman, A. Ernst, E. Bonde, J.P. Skakkebæk, N.E., & Olsen, J. (1998). Does moderate alcohol consumption affect fertility? Follow-up study among couples planning first pregnancy. BMJ, 317(7157), 505-510.

[45] Karayel, F. Turan, A .A. Sav, A. Pakis, I. Akyildiz, E.U Ersoy, G. Methanol intoxication: pathological changes of central nervous system (17 cases), Am. J. Forensic Med. Pathol. 31 (2010) 34–36.

[46] Koffi, F.C.R. Konan, B.R. Assemand, E. Assessment of physicochemical characters of traditional ‘‘Koutoukou’’from different raw materials, Int. J. Biosci. 10 (2017) 179–185.

[47] Kortei, N.K. Heymann, M.E. Essuman, E.K. Kpodo, F.M. Akonor, P.T. Lokpo, S.Y. Boadi, N.O. Ayim-Akonor, M. Tettey, C. Health risk assessment and levels of toxic metals in fishes (Oreochromis noliticus and Clarias anguillaris) from Ankobrah and Pra basins: impact of illegal mining activities on food safety, Toxicol. Rep. 7 (2020) 360–369.

[48] Krystal, J.H. Petrakis, I.L. Mason, G. Trevisan, L., & D'Souza, D.C. (2003). N-Methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther., 99(1), 79-94.

[49] Lanre-Iyanda, T.Y. & Adekunle, I.M. Assessment of heavy metals and their estimated daily intakes from two commonly consumed foods (Kulikuli and Robo) found in Nigeria. Afr. J. Food Agric. Nutr. Dev. 2012, 12, 6156–6169.

[50] MacDonald, S. Cherpitel, C.J. DeSouza, A. Stockwell, T. Borges, G., & Giesbrecht, N. Variations of alcohol impairment indifferent types, causes and contexts of injuries: Results de emergency room studies from 16 countries. Accid Anal Prev. 2006; 38(6):1107–12.

[51] MacSween, R.N. & Burt, A.D. (1986). Histologic spectrum of alcoholic liver disease. Semin Liver Dis., 6(3), 221-232.

[52] Maduabuchi, I.M.U. Nzegwu, C.N. Adigba, E.O. Oragwu, C.I. Agbo, F.N. Agbata, C.A. Ani, G.C., & Orisakwe, O.E (2008) Iron, manganese and nickel exposure from beverages in Nigeria: A public health concern. Journal of Health Science, 5(4), 335-338.

[53] Mbuagbaw, L. & Noorduyn, S. (2012). The Palm Wine Trade: Occupational and health hazards. The International Journal of Occupational and Environmental Medicine, 3, pp. 157-164.

[54] Moreira, E.D. Glasser, D.B. Nicolosi, A. Duarte, F.G., & Gingell, C. (2008). Sexual problems and help-seeking behaviour in adults in the United Kingdom and continental Europe. BJU Int., 101(8), 1005-1011.

[55] Muhammad, I. Ashiru, S. Ibrahim, I.D. Salawu, K. Muhammad, D.T., & Muhammad, N.A. Determination of some heavy metals in wastewater and sediment of artisanal gold local mining site of Abare Area in Nigeria. J. Environ. Treat. Tech. 2014, 1, 174–182.

[56] Nagy, J. Kolok, S. Dezso, P. Boros, A., & Szombathelyi, Z. (2003). Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Neurochem. Int., 42(1), 35-43.

[57] Nnorom, I.C. Osibanjo, O., & Ogugua K. (2007). Trace heavy metal levels of some bouillon cubes and food condiments readily consumed in Nigeria. Pakistan Journal of Nutrition,6(1), 122-127.

[58] Nuzhnyi, V. (2004). Chemical composition, toxic, and organoleptic properties of non-commercial alcohol samples. In Haworth A., & Simpson R. (eds.), Moonshine Markets. Issues in unrecorded alcohol beverage production and consumption. Pp 177– 199. New York: Brunner-Routledge.

[59] Nwaiwu, O. & Itumoh, M. (2017). Chemical contaminants associated with palm wine from Nigeria are potential food safety hazards. Beverages, 3(16), pp. 1-12.

[60] O’ Conell, D. & Patterson, H.A. Survey of current college alcohol abuse programs, attitudes and training needs. J Alcohol Drug Educ. 1989; 43(2):61-9.

[61] Obot, I.S. (2007). Nigeria: alcohol and society today. Addiction, 102, pp. 519–522.

[62] Ochu, J.O. Uzairu, A. Kagbu, J.A. Gimba, C.E., & Okunola, O. J. ((2012). Evaluation of some heavy metal in imported chocolate and candies sold in Nigeria. Journal of Food Research, 1(2), 169-177.

[63] Ochu, A.Majeed., Chegwe, F.E., Toby, D.T ., Okene, D. T & Akpoufuoma, O.F. Analyzing Toxic Heavy Metals in Industrial Discharge: Implications for Public Health. Iconic Research And Engineering Journals, 8(7), 2456-8880.

[64] Ohimain, E.I. Methanol contamination in traditionally fermented alcoholic beverages: the microbial dimension, Springerplus 5 (2016) 1–10.

[65] Onwukeme, V.I. & Okechukwu, V.U. (2021) IOSR J Environ Sci Toxicol Food Technol 15:4. https:// doi. org/ 10. 5620/ eaht. 20210 23

[66] Rehm, J. (2011) J Natl Institut Alcohol Abuse Alcoholism 34:2 (PMID: 22330211; PMCID: PMC3307043)

[67] Reinaldo, A.M.S. & Pillon, S.C. Alcohol effects on family relations: a case study. Rev. Latino-Am. Enfermagem. 2008; 16(esp):529-34.

[68] Rivier, C. Rivest, S., & Vale, W. (1992). Alcohol-induced inhibition of LH secretion in intact and gonadectomised male and female rats: Possible mechanisms. Alcohol., Clinical and Exp. Res., 16(5), 935-941.

[69] Ron, D. & Messing, R.O. (2013). Signaling pathways mediating alcohol effects. Curr. Topics Behav. Neurosci., 13, 87-126.

[70] Ron, D. (2004). Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist., 10(4), 325-336.

[71] Salama, J.S. Abate, D. Abay, S.M. Abbafati, C. Abdulkader, R.S. Abebe, Z. Aboyans, V. Abrar, M.M. Acharya, P. Adetokumbo, O.O. Adhikari, T.B. Adsuar, J.C. Afarideh, M. Agardh, E.E. Agarwal, G. Aghayan, S.A. Agarwal, S. Ahmed, M.B.; & Akibu, M. (2018) Lancet 392:1015–1035.

[72] Sam, T. (2015). Home-brewed gin kills 70 people in Nigeria. Daily Mail Online. https://www.dailymail.co.uk/news/article-3128777/Home-brewed-gin-kills-70-people-Nigeria-Health-officials-saylocal-drink-contain-large-amounts-me.

[73] Sayette, M.A (2017). Behav Res Ther. https:// doi. org/ 10. 1016/j. brat. 2016. 06. 005

[74] Shield, K.D. Parry, C., & Rehm, J. (2013). Chronic diseases and conditions related to alcohol use. Alcohol Res.: Curr. Rev., 35(2), 155-173.

[75] Silva, P.D. Cool, J.L., & Olson, K.L. (1999). Impact of lifestyle choices on female infertility. J Reprod. Med., 44(3), 288–296.

[76] Şimsek, M.G. Destanoglu, O.; & Yilmaz, G.G. (2020). Simultaneous determination of fluoride, acetate, formate, chloride, nitrate, and sulphate in distilled alcoholic beverages with ion chromatography/conductivity detector. Journal of the Turkish Chemical Society Section A: Chemistry, 7(3), pp. 661-674.

[77] Sofroniew, M.V. & Vinters, H.V. (2010). Astrocytes: biology and pathology. Acta Neuropathol. 119(1), 7-35.

[78] Song, D.Y. Song, S. Song, Y., & Lee, J.E. (2012). Alcohol intake and renal cell cancer risk: a meta-analysis. British J. Cancer, 106(11), 1881-1890.

[79] Stueve, A. & O´Donnell, L.N. Early alcohol initation and subsequent sexual and alcohol risk behaviours among urban youths. Am J Public Health. 2005; 95(4):887–93.

[80] Sylvester, C.I Iniobong, E.F Tariwari C.N., & Okowa, I. P. (2016). A review of heavy metals concentration and potential health implications of beverages consumed in Nigeria. http//:www.mdpi.com/ journal/toxics.

[81] Tchounwou, P.B. Yedjou, C.G. Patlolla, A.K., & Sutton, D.J. Heavy Metals Toxicity and the Environment. Natl. Inst. Health 2012, 101, 133–164.

[82] Tempier, R. Boyer, R. & Lambert, J. Psychological distrress among female spouses of male at – risk drinkers. Alcohol. 2006; 40(1):41-9.

[83] Thuong, N.T. Yoneda, M.; & Shimada, Y. (2015) Environ Earth Sci 73:3925–3936. https:// doi. org/ 10. 1007/ s12665- 014- 3678-7

[84] Tramacere, I. Negri, E. Pelucchi, C. Bagnardi, V. Rota, M. Scotti L. Islami, F. Corrao, G. La Vecchia, C., & Boffetta, P. (2012). A meta-analysis on alcohol drinking and gas-tric cancer risk. Ann. Oncol., 23(1), 28-36.

[85] Tulashie, S.K. Appiah, A.P. Torku, G.D. Darko, A.Y. Wiredu, A. Determination of methanol and ethanol concentrations in local and foreign alcoholic drinks and food products (Banku, Ga kenkey, Fante kenkey and Hausa koko) in Ghana, Int. J. Food Contamination 4 (2017) 1–5 .

[86] Tuma, D.J. & Casey, C.A. (2003). Dangerous byproducts of alcohol breakdown-focus on adducts. Alcohol Res. Health, 27(4), 285-290.

[87] Udota, H.I.J. & Umoudofia, S.J. Heavy metal contamination of some selected Nigerian and imported alcoholic drinks, I Control Pollut. (2011) 27.

[88] Vaillant, G.E. & Keller, M. (2021) Encyclopaedia Britannica,. https:// www. brita nnica. com/ topic/ alcoh ol- consu mption. Accessed 14 Apr 2022.

[89] Velásquez, J. & Scoppetta, O. Consumo de sustancias psicoactivas en estudiantes de carreras técnicas y tecnológicas de Santa Fe de Bogotá. Bogotá; 1998. 80 p.

[90] Voica, C. Magdas, D. (2015) Feher. J Chem. https:// doi. org/ 10. 1155/ 2015/ 192032

[91] Vonlaufen, A. Wilson, J.S. Pirola, R.C., & Apte, M.V. (2007). Role of alcohol metabolism in chronic pancreatitis. Alcohol Res. Health, 30(1), 48-54.

[92] Walter, B. & Silliker, C.C. (2016, November 1st). Heavy metal contamination in food products. http://www.info.silliker.com/industryinsights/issue4/pdf d

[93] Wanga, J. Du, H. Jiang, L. Ma, X., de Graaf, R.A. Behar, K.L., & Mason, G.F. (2013). Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proc. Nat. Acad. Sci. USA, 110(35), 14444-14449.

[94] WHO (2003). Chloride in Drinking-water. 2003. Contract No.: WHO/SDE/WSH/03.04/03.

[95] Worldwide alcohol consumption declines. International Wines and Spirit Records (IWSR), (2019). Retrieved 2019-06-04.

[96] Woyessa, G.W. Kassa, S.B. Demissie, E.G., & Srivastava, B.B.L. (2015). Determination of the level of some trace and heavy metals some soft drinks of Ethiopia. International Journal of Current Research, 2(1), 84-88.

[97] Yang, X. Criswell, H.E. Simson, P. Moy, S., & Breese, G.R. (1996). Evidence for a selective effect of ethanol on N-methyl-D-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther., 278(1), 114-124.

[98] Zhou, X. Su, Z. Anishkin, A. Haynes, W.J. Friske, E.M. Loukin S.H. Kung, C., & Saimi, Y. (2007). Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate. Proc. Natl. Acad. Sci. USA., 104(39), 15555-15559.

How to cite this paper

Appah Matthew Omomoni, Ochu Abdulmajeed, Okene Doutimi Tebekaemi, Akpoufuoma Oghenetega Friday, Toby David Timipere "Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria" Iconic Research And Engineering Journals Volume 8 Issue 8 2025 Page 857-866
Appah Matthew Omomoni, Ochu Abdulmajeed, Okene Doutimi Tebekaemi, Akpoufuoma Oghenetega Friday, Toby David Timipere "Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria" Iconic Research And Engineering Journals, vol. 8, no. 8, Feb. 2025
Appah Matthew Omomoni, Ochu Abdulmajeed, Okene Doutimi Tebekaemi, Akpoufuoma Oghenetega Friday, Toby David Timipere (2025). Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria. Iconic Research And Engineering Journals, 8(8).
Appah Matthew Omomoni, Ochu Abdulmajeed, Okene Doutimi Tebekaemi, Akpoufuoma Oghenetega Friday, Toby David Timipere "Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria" Iconic Research And Engineering Journals, vol. 8, no. 8, Feb. 2025.
@article{1707251,
      author = {Appah Matthew Omomoni, Ochu Abdulmajeed, Okene Doutimi Tebekaemi, Akpoufuoma Oghenetega Friday, Toby David Timipere},
      title = {Assessment of Heavy Metal Contamination in Locally Produced Dry Gin and Associated Health Risks in Ogbia Local Government Area, Bayelsa State, Nigeria},
      journal = {Iconic Research And Engineering Journals},
      year = {2025},
      volume = {8},
      number = {8},
      pages = {857-866},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1707251.pdf},
      abstract = {The contamination of alcoholic beverages with heavy metals poses serious public health concerns, particularly when their concentrations exceed safe limits established by regulatory bodies such as the World Health Organization (WHO). This study evaluates the toxicological profile of heavy metals in locally produced dry gin from Ogbia Local Government Area, Bayelsa State, Nigeria, and assesses the associated health risks. Thirty (30) gin samples were collected from production centers in Atubu Creek-Onuebum and analyzed using Atomic Absorption Spectrophotometry (AAS) to determine the concentrations of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), nickel (Ni), zinc (Zn), and lead (Pb). The results revealed significant concentrations of As (1.553 ? 0.101 ?g/mL), Hg (1.683 ? 0.209 ?g/mL), Pb (3.123 ? 0.25 ?g/mL), Cu (0.240 ? 0.002 ?g/mL), and Mn (0.613 ? 0.05 ?g/mL). Comparing these values with WHO permissible limits for drinking water and alcoholic beverages, the concentrations of As (0.01 ?g/mL), Hg (0.006 ?g/mL), and Pb (0.01 ?g/mL) were found to be significantly higher in the gin samples, indicating potential health risks such as neurotoxicity, organ damage, and carcinogenic effects. While Cu and Mn were detected within WHO safe limits (2.0 ?g/mL for Cu and 0.5 ?g/mL for Mn), their presence in alcoholic beverages still raises concerns due to the potential for bioaccumulation. Other metals, including Cd, Co, Cr, Ni, and Zn, were detected at trace levels but remained below WHO limits. The high concentrations of heavy metals in local dry gin may be attributed to contamination from raw materials, production techniques, and storage conditions. Given these findings, urgent regulatory intervention, public sensitization, and stricter enforcement of production standards are necessary to mitigate heavy metal exposure from local alcoholic beverages.},
      keywords = {Heavy metals, local dry gin, toxicological assessment, WHO limits, health risks, Ogbia LGA, Atomic Absorption Spectrophotometry (AAS).},
      month = {February},
  }