Hepatorenal Effects of Curcumin and Piperine in Lipopolysaccharide-Induced Systemic Inflammation in Wistar Rats: A Review
Abstract
Lipopolysaccharide (LPS)-induced systemic inflammation is a well-established model for studying sepsis and its detrimental effects on vital organs, including the liver and kidneys. Both curcumin, a polyphenolic compound derived from Curcuma longa, and piperine, an alkaloid from Piper nigrum, have demonstrated potent anti-inflammatory and antioxidant properties. This review aims to evaluate the protective roles of curcumin and piperine against LPS-induced hepatic and renal damage in Wistar rats. The review highlights the mechanisms by which these compounds exert their effects, including the reduction of oxidative stress, inhibition of pro-inflammatory cytokines, enhancement of antioxidant defenses, and amelioration of histopathological abnormalities. Curcumin modulates various biochemical pathways to reduce inflammation, while piperine enhances curcumin's bioavailability, facilitating its therapeutic efficacy. When used in combination, curcumin and piperine show synergistic effects in reducing LPS-induced organ injury. The co-administration of these compounds not only improves biochemical markers of liver and kidney function but also restores histopathological features, offering a promising therapeutic strategy for managing systemic inflammation. This review synthesizes current findings on the efficacy of curcumin and piperine in mitigating organ damage caused by LPS and discusses their potential as adjuncts to traditional anti-inflammatory therapies.
Keywords
Lipopolysaccharide (LPS), curcumin, piperine, systemic inflammation, hepatic damage, renal damage, antioxidant, inflammation, Wistar rats, synergistic effects.
Citations
IRE Journals:
AKEREDOLU Florence Funke , EKUNDINA Victor Olukayode , AGBOMHERE Mose Hammed
"Hepatorenal Effects of Curcumin and Piperine in Lipopolysaccharide-Induced Systemic Inflammation in Wistar Rats: A Review" Iconic Research And Engineering Journals Volume 8 Issue 11 2025 Page 735-737
IEEE:
AKEREDOLU Florence Funke , EKUNDINA Victor Olukayode , AGBOMHERE Mose Hammed
"Hepatorenal Effects of Curcumin and Piperine in Lipopolysaccharide-Induced Systemic Inflammation in Wistar Rats: A Review" Iconic Research And Engineering Journals, 8(11)
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