Hepatoprotective Effect of Coconut Oil Against Aluminium Chloride and D-Galactose-Induced Hepatotoxicity in Male Wistar Rats

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@article{1709029,
      author = {Onesimus Mahdi, Kuchahyells Mathias; Simeon Benjamin, Khadijat Abubakar Bobbo; Abel Nosoreme Agbon, Lawan Ibrahim Aliyu; Anathoth Alhassan, Deborah Dilla; Raphael Reseph},
      title = {Hepatoprotective Effect of Coconut Oil Against Aluminium Chloride and D-Galactose-Induced Hepatotoxicity in Male Wistar Rats},
      journal = {Iconic Research And Engineering Journals},
      year = {2025},
      volume = {8},
      number = {10},
      pages = {1530-1538},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1709029.pdf},
      abstract = {Background: Damage or Injury to the liver as a result of exposure to certain harmful drugs known as hepatotoxins is referred to as hepatotoxicity, this condition is becoming highly alarming as it contributes to over two (2) million death annually and worldwide. After administering virgin coconut oil (VCO)to rat models of hepatotoxicity induced with Aluminium Chloride (AlCl3) and D-galactose (D-gal), serum levels of liver enzymes and histopathological alterations in the hepatic tissue were evaluated.
Objectives: The current study investigated the hepatoprotective effect of virgin coconut oil against AlCl3 and D-gal induced hepatotoxicity in male Wistar rats. 
Materials and methods: Twenty eight (28) healthy male Wistar rats were used in this study. VCO (1 ml/kg and 3 ml/kg) was given orally to the AlCl3 and D-gal induced hepatotoxic rats for four (4) weeks. At the end of treatment, blood samples were collected for the determination of serum levels of liver enzymes. The liver was harvested processed and histopathological changes as result of the adminstration of AlCl3 and D-gal to the liver were also documented.
Results: VCO administration significantly raised the serum levels of globulin and total protein, while lowering alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels and also suppressing histopathological changes such as venular congestion, interlobular degeneration, presence of excess kupffer cells and fibrosis alterations in the liver.
Conclusion: Virgin coconut cil has a hepatoprotective effect against Aluminium Chloride and D-galactose-induced hepatotoxicity by attenuating histological changes and normalizing the serum levels of liver enzymes.
},
      keywords = {Virgin Coconut Oil, Hepatotoxicity, Histopathology, Aluminium Chloride and D-galactose.},
      month = {April},
  }