Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats

@article{1709998,
      author = {Lutfat Abimbola Usman, Emmanuel Oladipo Ajani},
      title = {Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats},
      journal = {Iconic Research And Engineering Journals},
      year = {2025},
      volume = {9},
      number = {2},
      pages = {40-46},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1709998.pdf},
      abstract = {Neurodegenerative diseases, characterized by neuroinflammation, pose significant global health challenges, exacerbated by environmental toxins like acrylonitrile (AN). This study investigates the anti-inflammatory potential of Tamarindus indica fruit pulp ethanolic extract in an AN-induced neuroinflammation model in male Wistar rats. Seventy rats were divided into seven groups, receiving varying doses of T. indica extract (200 or 400 mg/kg body weight) either preventively or therapeutically alongside AN exposure, with normal and positive controls. Brain homogenates were analyzed for pro-inflammatory cytokines (IL-6, IL-1?, and TNF-?) using ELISA techniques. Results revealed significant reductions in cytokine levels in both preventive and treatment groups compared to the negative control, with the lowest IL-6 levels in the high-dose treatment group (4.899?0.023 pg/mL) and the lowest IL-1? and TNF-? levels in the low-dose preventive group. These findings suggest that T. indica extract effectively mitigates AN-induced neuroinflammation, likely through modulation of inflammatory pathways, highlighting its potential as a cost-effective, natural therapeutic for neurodegenerative diseases.},
      keywords = {Neuroinflammation, Tamarindus Indica, Acrylonitrile, Pro-Inflammatory Cytokines, Neurodegenerative Diseases},
      month = {August},
  }