Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats
Abstract
Neurodegenerative diseases, characterized by neuroinflammation, pose significant global health challenges, exacerbated by environmental toxins like acrylonitrile (AN). This study investigates the anti-inflammatory potential of Tamarindus indica fruit pulp ethanolic extract in an AN-induced neuroinflammation model in male Wistar rats. Seventy rats were divided into seven groups, receiving varying doses of T. indica extract (200 or 400 mg/kg body weight) either preventively or therapeutically alongside AN exposure, with normal and positive controls. Brain homogenates were analyzed for pro-inflammatory cytokines (IL-6, IL-1?, and TNF-?) using ELISA techniques. Results revealed significant reductions in cytokine levels in both preventive and treatment groups compared to the negative control, with the lowest IL-6 levels in the high-dose treatment group (4.899±0.023 pg/mL) and the lowest IL-1? and TNF-? levels in the low-dose preventive group. These findings suggest that T. indica extract effectively mitigates AN-induced neuroinflammation, likely through modulation of inflammatory pathways, highlighting its potential as a cost-effective, natural therapeutic for neurodegenerative diseases.
Keywords
Neuroinflammation, Tamarindus Indica, Acrylonitrile, Pro-Inflammatory Cytokines, Neurodegenerative Diseases
Citations
IRE Journals:
Lutfat Abimbola Usman , Emmanuel Oladipo Ajani
"Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats" Iconic Research And Engineering Journals Volume 9 Issue 2 2025 Page 40-46
IEEE:
Lutfat Abimbola Usman , Emmanuel Oladipo Ajani
"Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats" Iconic Research And Engineering Journals, 9(2)
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