Effects of Launaea taraxacifolia (Wild Lettuce) Aqueous Extract in Cadmium Chloride-Induced Alzheimer?s Disease-Like Neurodegeneration in Male Wistar Rats
Abstract
Alzheimer?s disease (AD), characterized by progressive neurodegeneration and cognitive dysfunction, continues to pose significant treatment hurdles, particularly when environmental neurotoxins like cadmium trigger or exacerbate the condition. Launaea taraxacifolia, a medicinal plant with known antioxidant property, may offer therapeutic potential against cadmium chloride-induced Alzheimer?s disease-like neurodegeneration. This study was designed to investigate the efficacy of Launaea taraxacifolia aqueous extract in mitigating cadmium chloride-induced Alzheimer?s disease-like neurodegeneration in male wistar rats. This study used thirty-two (32) adult male wistar rats. There were four groups of eight rats each. For 21 days, Group I were given distilled water orally; Group II were given 5 mg/kg of CdCl2 orally; Group III were given 400 mg/kg of LTAE orally; and Group IV were given 5 mg/kg of CdCl2, followed by 400 mg/kg of LTAE orally. CdCl2 caused a significant decrease (p<0.05) in neurobehavioural parameters (Y maze and open field), revealed alteration of the neuronal cytoarchitecture (neuronal loss and neurofibrillary tangles) of the cerebral cortex and hippocampus, respectively. Similarly, co-administration of LTAE with CdCl2 inhibited cadmium chloride-induced Alzheimer?s disease-like neurodegeneration by reversing the altered microanatomy of the cerebral and hippocampus of rat, and changes in neurobehavioural parameters. It is concluded that LTAE effectively ameliorates Alzheimer?s disease-like neurodegeneration following CdCl2 treatment and maybe a therapeutic strategy against the neurological consequences of CdCl2 overexposure.
Keywords
Alzheimer?s disease, Cadmium Chloride, Neurodegeneration, Launaea taraxacifolia, Cresyl fast violet staining.
Citations
IRE Journals:
Esther Oluwadamilola Adejola, Toluwase Solomon Olawuyi, Grace Temitope Akingbade "Effects of Launaea taraxacifolia (Wild Lettuce) Aqueous Extract in Cadmium Chloride-Induced Alzheimer?s Disease-Like Neurodegeneration in Male Wistar Rats" Iconic Research And Engineering Journals Volume 9 Issue 5 2025 Page 65-74
IEEE:
Esther Oluwadamilola Adejola, Toluwase Solomon Olawuyi, Grace Temitope Akingbade
"Effects of Launaea taraxacifolia (Wild Lettuce) Aqueous Extract in Cadmium Chloride-Induced Alzheimer?s Disease-Like Neurodegeneration in Male Wistar Rats" Iconic Research And Engineering Journals, 9(5)
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