Effect Of Methanol Leaf Extract of Voacanga Africana on Selected Biochemical Indices in Alloxan-Induced Diabetic Wistar Albino Rats.

References

[1] Agbafor, K.N. (2004). The Effects of Aqueous and Organic Extract of Baphian nitida on tissue acetylcholine Estrase in Guinea Pigs. Journal of Science and Technology, 10(7);1-6

[2] American Diabetes Association (2023). Classification and diagnosis of diabetes. Diabetes Care, 46(Suppl. 1), S19–S40.

[3] Battu, G.R., Mamidipalli, S.N., Parimi, R., Viriyala, R.K., Patchula, R.P. and Mood L.R. (2007). Hypoglycaemic and antihyperglycemic effect of alcoholic extract of Benincasa hispida in normal and in alloxan induced diabetic rats. Pharmacognosy Magazine.

[4] Burkill, H. M. (2000). The useful plants of West Tropical Africa (Vol. 5). Royal Botanic Gardens, Kew.

[5] Eidi, A., Eidi, M., & Esmaeili, E. (2006). Antidiabetic effect of Salvia officinalis L. in normal and diabetic rats. Phytotherapy Research, 20, 882–887.

[6] Forbes, J. M., & Cooper, M. E. (2013). Mechanisms of diabetic complications. Physiological Reviews, 93, 137–188.

[7] Grover, J. K., Vats, V., & Rathi, S. S. (2000). Anti-hyperglycemic effect of medicinal plants in experimental diabetes. Journal of Ethnopharmacology, 73, 461–470.

[8] Ha, H., & Kim, K. H. (1999). Role of oxidative stress in the development of diabetic nephropathy. Kidney International, 56, S18–S21.

[9] Harborne, J. B. (1998). Phytochemical methods: A guide to modern techniques of plant analysis. Chapman & Hall.

[10] International Diabetes Federation (IDF) (2021). IDF Diabetes Atlas (10th ed.). Brussels, Belgium.

[11] Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 51, 216–226.

[12] Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 51, 216–226.

[13] Little, R. R., & Sacks, D. B. (2009). HbA1c: How do we measure it and what does it mean? Current Opinion in Endocrinology, Diabetes and Obesity, 16(2), 113–118.

[14] Modak, M., Dixit, P., Londhe, J., Ghaskadbi, S., & Devasagayam, T. P. A. (2007). Indian herbs and herbal drugs used for the treatment of diabetes. Journal of Clinical Biochemistry and Nutrition, 40, 163–173.

[15] Mogensen, C. E. (1999). Microalbuminuria and hypertension in diabetes. Journal of Internal Medicine, 245(5), 381–391.

[16] Nagappa, A.N., Thakurdesai, P.A., Venkat, R. N. and Singh, J. (2003). Antidiabetic activity of Terminalia catappa linn fruits. Journal of Ethanopharmacology. 88:45-50.

[17] Neuwinger, H. D. (2000). African traditional medicine: A dictionary of plant use and applications. Medpharm Scientific Publishers.

[18] Neuwinger, H. D. (2000). African traditional medicine: A dictionary of plant use and applications. Medpharm Scientific Publishers.

[19] Osinubi, A.A., Ajayi, O.G., Adesiyun, A.E. (2006). Evaluation of the anti-diabetic effect of aqueous leaf extracts of Tripinanthus butungil in male spragne Dawley rats. 101 – 105.

[20] Sofowora, A., Ogunbodede, E., & Onayade, A. (2013). The role and place of medicinal plants in disease prevention. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 210–229.

[21] Sofowora, A., Ogunbodede, E., & Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 210–229.

[22] Szkudelski, T. (2001). The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiological Research, 50, 537–546.

[23] Szkudelski, T. (2001). The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiological Research, 50, 537–546.

[24] Tiwari, P., Kumar, B., Kaur, M., Kaur, G., & Kaur, H. (2011). Phytochemical screening and extraction: A review. International Pharmaceutica Sciencia, 1(1), 98–106.

[25] Tiwari, P., Kumar, B., Kaur, M., Kaur, G., & Kaur, H. (2011). Phytochemical screening and extraction: A review. Internationale Pharmaceutica Sciencia, 1(1), 98–106.

[26] Tiwari, V. and Singh, A. (2013). Antinociceptive and antioxidant potential of Bauhinia tomentosa extracts in experimental animal models. National Productivity Journal. 3:309–316.

[27] World Health Organization (2019). WHO global report on diabetes. Geneva.

@article{1714467,
      author = {Achilike, Joseph Johnbosco, Joel, Obinna Mark},
      title = {Effect Of Methanol Leaf Extract of Voacanga Africana on Selected Biochemical Indices in Alloxan-Induced Diabetic Wistar Albino Rats.},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {8},
      pages = {1335-1341},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1714467.pdf},
      abstract = {Diabetes mellitus is a chronic metabolic disorder associated with persistent hyperglycaemia and progressive tissue disorder leading to organ damage. Medicinal plants remain a valuable source of alternative antidiabetic agents with potential efficacy and reduced side effects. Voacanga africana is traditionally used in the management of metabolic disorders; however, its antidiabetic potential has not been adequately validated scientifically. This study evaluated the effect of methanol leaf extract of Voacanga africana on blood glucose levels, body weight, glycated hemoglobin (HbA1c), and urinary albumin–creatinine ratio (UACR) in alloxan-induced diabetic Wistar albino rats. Diabetes was induced in rats using alloxan monohydrate. Animals were divided into eight groups comprising normal control, diabetic control, glibenclamide-treated, and extract-treated groups (200, 400, 600, 800, and 1000 mg/kg body weight). Treatments were administered orally for 21 days. Fasting blood glucose was monitored at regular intervals, body weight changes were recorded, while HbA1c and UACR were evaluated at the end of the experiment. Data were analyzed using one-way ANOVA. Alloxan-induced diabetic rats exhibited persistent hyperglycaemia, weight loss, elevated HbA1c, and increased UACR. Treatment with methanol leaf extract of Voacanga africana resulted in a significant (p < 0.05), dose-dependent reduction in fasting blood glucose levels and HbA1c, with higher doses showing effects comparable to glibenclamide. Extract-treated rats also demonstrated significant improvement in body weight and a marked reduction in UACR, indicating improved metabolic control and renal protection. Methanol leaf extract of Voacanga africana exhibits significant antidiabetic and renal protective effects in alloxan-induced diabetic rats. These findings support its traditional use and suggest its potential as a natural therapeutic agent for the management of diabetes mellitus and its associated complications.},
      keywords = {Voacanga Africana, Diabetes Mellitus, Alloxan, Blood Glucose, Hba1c, UACR, Medicinal Plants},
      month = {February},
      doi = {https://doi.org/10.64388/IREV9I8-1714467}
  }