Process Development and Intensification of Chemical Reaction

References

[1] L. F. Prescott, 2000, ‘Paracetamol: past, present, and future’, Am. J. Ther. 7(2), 143-147.

[2] B.J. Anderson, Pediatric Anesthesia 2004 14: 201–217

[3] Croxall W.J, Mirza J., 1957, ‘N-Acylation of p-Aminophenols’, US Patent 2799692

[4] Godfrey W., De Angelis J., 1961, ‘Process of preparation of n-acetyl p-aminophenol’ US Patent 2998450

[5] Hahn J.H., Quinn J.F. 1962, ‘N-acetyl aminophenol Process’, US Patent 3042719

[6] Young D.W., 1963, ‘N-Acylation of Para Amino phenol’ US Patent 3081321

[7] Young D.W., 1963, ‘Production of N-Acylated P-Aminophenol’, US Patent 3081322

[8] Shulman H.L., Baron F.A., Weinberg A.E., 1975, ’Preparation of N-acetyl P-aminophenol’ US Patent 3917695

[9] Keel B.L., Klaus I.S., Oftedahl M.L., 1983, ‘Purification of N-acetyl aminophenols’, US Patent 4474985

[10] Ganboa I., Palomo C., 1983, 'Reagents and Synthetic Methods 33. Improved One-Step Beckmann Rearrangement from Ketones and Hydroxylamine in Formic Acid Solution.', Synthetic Communications, 13:11, 941-944

[11] Davenport K.G., Hilton C.B., 1985, ‘Process for Producing N-acyl-hydroxy aromatic amines’ US Patent 4524217

[12] Fruchey O.S., 1990, ‘Novel Process to prevent formation of chlorinated By-Products in APAP Production’ US Patent 4973752

[13] Davenport K.G., Sheldon R.A., LeBars J., Mueller W.H., 1995, ‘Process for Preparing 4-Hydroxyacetonphenone Oxime’ US Patent 5466869

[14] De Luca L., Giacomelli G., Porcheddu A., 2002, ‘Beckmann Rearrangement of Oxime under Very Mild Conditions’ Journal of Organic Chemistry 67, 6272-6274

[15] Abdullaev M. G., Klyuev M. V., 2005, ‘4-Acetaminophenol and 4-Hydroxyphenylsalicylamide Synthesized by Reductive Acylation of 4-Nitrophenol On Palladium Catalysts’ Pharmaceutical Chemistry Journal Vol. 39, 37-39

[16] Dekamin M.G., Nazary N., Synthesis of Acetaminophen by Liquid Phase Beckmann Rearrangement of 4 Hydroxyacetophenone Oxime over Nano Ordered Zn-MCM-41

[17] Ghiaci M., Aghaei H., Oroojeni M., Aghabarari B., Rives V., Vicente M.A., Sobrados I., Sanz J., 2009 Synthesis of paracetamol by liquid phase Beckmann rearrangement of 4-hydroxyacetophenone oxime over H3PO4/Al MCM-41 Catalysis Communications 10, 1486–1492

[18] C. V. Rode, M. J. Vaidya, R. Jaganathan, R. V. Chaudhari, Chemical Engineering Science 2001, Vol. 56, pp. 1299

[19] E. Friderichs, T. Christoph, H. Buschmann, Analgesics, and Antipyretics in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, 2007, pp. 8.

[20] J. R. Fritsch, O. S. Fruchey, T. Horlenkio, US patent 4,954,652, 1990. P 100

[21] NIR Board, Paracetamol – An Analysis of Technology for Cleaner Production in Drugs & Pharmaceutical Technology Handbook, Asia Pacific Buisness Press Inc., 2004

[22] O. Cãlinescu, I. A. Badea, L. Vlãdescu et. al., HPLC Separation of Acetaminophen and its Impurities Using a Mixed-mode Reversed-Phase/Cation Exchange Stationary Phase, Journal of Chromatographic Science, 2012; Vol. 50, pp. 335-342.

[23] K. V. R. Prasad, R. I. Ristic, D. B. Sheen et. al., Crystallization of paracetamol from solution in the presence and absence of impurity, International Journal of Pharmaceutics, 2001, Vol. 215, pp. 29-44.

[24] C. Thompson, M. C. Davies, C. J. Roberts et. al., The effects of additives on the growth and morphology of paracetamol (acetaminophen) crystals, International Journal of Pharmaceutics, 2004, Vol. 280, pp. 137-150.

@article{1715223,
      author = {Vaishnavi Nipun Kore, Dr. S. V. Anekar, Prof. S. S. Patil, Prof. Y. S. Patil},
      title = {Process Development and Intensification of Chemical Reaction},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {9},
      pages = {1572-1577},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1715223.pdf},
      abstract = {The chemical industries are pivotal to the modern world and works to convert raw materials such as oil painting, natural gas, air, water, essence, and minerals into more than 70,000 different products. These base products are also used to make consumer products in addition to manufacturing, service, construction and other. The process of the organic chemicals by using a zero waste discharge technology and the solvent recovery to make a green reaction, which is economically feasible as well grounded on the conception of waste management by using the different types of catalyst and studying the part catalyst in the reaction. In the upstream reaction an amidation reaction is developed here in the project of the pharmaceutical intermediate or product which is extensively used in chemical and pharmaceuticals. The use of the zero valent palladiumnano catalyst system for amidation of aryl halides which has not been efficiently proved. The reaction is well liberalized toward a variety of functional aryl halides and a wide range of aromatic and aliphatic primary amides in good to excellent yields. Nanoparticles having extraordinarily large surface area and huge number of active sites in comparison to bulk material act as effective catalyst for organic synthesis.},
      month = {March},
      doi = {https://doi.org/10.64388/IREV9I9-1715223}
  }