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Effect of Ethanolic Extract of Desmondium Adscendens Leaves On Some Oxidative Stress Indices in Phenylhydrazine Administered Wistar Rats
Subject area: Biological & Medical Sciences · Area of research: Physiology
DOI: https://doi.org/10.64388/IREV9I10-1716081
Abstract
Background: Medicinal plants, when regulated and used correctly can help to prevent and treat a variety of health conditions. We investigated the ameliorative potential of Desmondium adscendens leave (EDAL) extract on oxidative stress indices in Phenylhydrazine administered rats. Method: Twenty-five (25) male Wistar rats weighing 180-200g, were randomly assigned to 5 groups of five rats each. Group1(normal control), Group 2(PHZ) was challenged with phenylhydrazine (60mg/kg, B.W., intraperitoneal) without treatment. Group 3 received EDAL orally at 150mg/kg, B.W., Group 4 and 5 were challenged with phenylhydrazine (60mg/kg, B.W,) and treated orally with 150mg/kg and 300mg/kg of extract of Desmondium adscendens leaves (EDAL) respectively. All animals were allowed free access to food and water pre and post treatment for 14 days. At the end of the treatment period, the animals were euthanized, and blood samples collected via cardiac puncture for biochemical analysis. Result: Oxidative stress indices (SOD, CAT and GSH) revealed significant(P<0.05) decrease, except MDA which increased in PHZ group compared to normal group and extract group. However, there was improvement in the above biochemical parameters in extract treated group, when compared with the PHZ group. Conclusion: Our findings suggest that the extract of Desmondium adscendens leaves has the capacity to ameliorates the Phenylhydrazine-induced oxidant-antioxidant imbalances in Wistar rats.
Keywords
Desmondium adscendens, Phenylhydrazine, Biochemical indices
How to cite this paper
@article{1716081,
author = {Uquetan Sam Uquetan, Ekerette Sampson Udo, Okoi, Clement Okoi, Anietie Akpan Jacob; Okoi Dominic Obeten, Agogo Emmanuel Ugi; Ibitham Ibitham Ijim},
title = {Effect of Ethanolic Extract of Desmondium Adscendens Leaves On Some Oxidative Stress Indices in Phenylhydrazine Administered Wistar Rats},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {9},
number = {10},
pages = {716-721},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1716081.pdf},
abstract = {Background: Medicinal plants, when regulated and used correctly can help to prevent and treat a variety of health conditions. We investigated the ameliorative potential of Desmondium adscendens leave (EDAL) extract on oxidative stress indices in Phenylhydrazine administered rats.
Method: Twenty-five (25) male Wistar rats weighing 180-200g, were randomly assigned to 5 groups of five rats each. Group1(normal control), Group 2(PHZ) was challenged with phenylhydrazine (60mg/kg, B.W., intraperitoneal) without treatment. Group 3 received EDAL orally at 150mg/kg, B.W., Group 4 and 5 were challenged with phenylhydrazine (60mg/kg, B.W,) and treated orally with 150mg/kg and 300mg/kg of extract of Desmondium adscendens leaves (EDAL) respectively. All animals were allowed free access to food and water pre and post treatment for 14 days. At the end of the treatment period, the animals were euthanized, and blood samples collected via cardiac puncture for biochemical analysis.
Result: Oxidative stress indices (SOD, CAT and GSH) revealed significant(P<0.05) decrease, except MDA which increased in PHZ group compared to normal group and extract group. However, there was improvement in the above biochemical parameters in extract treated group, when compared with the PHZ group.
Conclusion: Our findings suggest that the extract of Desmondium adscendens leaves has the capacity to ameliorates the Phenylhydrazine-induced oxidant-antioxidant imbalances in Wistar rats.
},
keywords = {Desmondium adscendens, Phenylhydrazine, Biochemical indices},
month = {April},
doi = {https://doi.org/10.64388/IREV9I10-1716081}
}