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Synthesis, Characterization and Antimic6 Activity of Some Pyrazole Derivative
Subject area: Science,Engineering and Technology · Area of research: Pharmaceutical Chemistry
DOI: https://doi.org/10.64388/IREV9I11-1717424
Abstract
Objective: The present study aimed to evaluate the antibacterial activity of different Pyrazole derivatives (4A–E) and screened against selected pathogenic microorganisms and to compare their efficacy with a standard antibiotic. Materials and Methods: The antibacterial activity of the developed formulations was assessed against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus using the zone of inhibition method. The results were compared with the standard drug tetracycline to determine relative efficacy. Results: Among all formulations, 5B and 5C demonstrated the highest antibacterial activity, exhibiting significant zones of inhibition against all tested microorganisms. Strong activity was particularly observed against Pseudomonas aeruginosa and Staphylococcus aureus, indicating broad-spectrum effectiveness. Other formulations showed moderate to low activity, while some exhibited no inhibition against Klebsiella pneumoniae.
Keywords
Antibacterial, Pyrazole, Klebsiella Pneumoniae.
References
[1] Masaret, Ghada S. "A new approach for the synthesis and biological activities of novel thiazolyl‐carbazole derivatives." ChemistrySelect 6, no. 5 (2021): 974-982.
[2] Alsayari, Abdulrhman, Yahya I. Asiri, Abdullatif Bin Muhsinah, and Mohd Hassan. "Anticolon cancer properties of carbazole derivatives acting through xanthine oxidase inhibition." Journal of Oncology 2021 (2021).
[3] Azimi, Fateme, Homa Azizian, Mohammad Najafi, Farshid Hassanzadeh, Hojjat Sadeghi-Aliabadi, Jahan B. Ghasemi, Mohammad Ali Faramarzi et al. "Design and synthesis of novel quinazolinone-carbazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study." Bioorganic Chemistry 114 (2021): 10512-17.
[4] Nourmahammadi, Jalal, Ebrahim S. Moghadam, Zahra Shahsavari, and Mohsen Amini. "Design, synthesis and biological evaluation of novel diaryl carbazole derivatives as anticancer agents." Letters in Organic Chemistry 17, no. 3 (2020): 216-223.
[5] Chalkha, Mohammed, Mohamed Bakhouch, Mohamed Akhazzane, Mohamed Bourass, Yohann Nicolas, Ghali Al Houari, and Mohamed El Yazidi. "Design, synthesis and characterization of functionalized carbazole derivatives bearing amide and sulfonamide moieties from aza-aurones." Journal of Chemical Sciences 132 (2020): 1-8.
[6] Ren, Bo, Rong-Chun Liu, Kegong Ji, Jiang-Jiang Tang, and Jin-Ming Gao. "Design, synthesis and in vitro antitumor evaluation of novel carbazole-benzimidazole derivatives." Bioorganic & Medicinal Chemistry Letters 43 (2021): 128097.
[7] Reddy, Guda Mallikarjuna, Jarem Raul Garcia, Gutha Yuvaraja, Munagapati Venkata Subbaiah, and Jet‐Chau Wen. "Design, synthesis of tri‐substituted carbazole derivatives as promising antimicrobial agents and investigation of structure activity relationships." Journal of Heterocyclic Chemistry 57, no. 5 (2020): 2288-2296.
[8] Saleh, Ibrahim, Hansa Raj Kc, Subrata Roy, Mohd Kotaiba Abugazleh, Hashim Ali, David Gilmore, and Mohammad A. Alam. "Design, synthesis, and antibacterial activity of N-(trifluoromethyl) phenyl substituted carbazole derivatives." RSC Medicinal Chemistry 12, no. 10 (2021): 1690-1697.
[9] Chalkha, Mohammed, Mohamed Akhazzane, Fatima Zahrae Moussaid, Ossama Daoui, Asmae Nakkabi, Mohamed Bakhouch, Samir Chtita, Souad Elkhattabi, Abdelilah Iraqi Housseini, and Mohamed El Yazidi. "Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel carbazole derivatives as antimicrobial agents." New Journal of Chemistry 46, no. 6 (2022): 2747-2760.
[10] Dizdaroglu, Yazgı, Canan Albay, Tayfun Arslan, Abdulilah Ece, Emir A. Turkoglu, Asiye Efe, Murat Senturk, Claudiu T. Supuran, and Deniz Ekinci. "Design, synthesis and molecular modelling studies of some carbazole derivatives as carbonic anhydrase inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry 35, no. 1 (2020): 289-297.
[11] Ali, Sahar A., Samir Mohamed Awad, Ahmed Mohammed Said, Shahenda Mahgoub, Heba Taha, and Naglaa Mohamed Ahmed. "Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-carbazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors." Journal of enzyme inhibition and medicinal chemistry 35, no. 1 (2020): 847-863.
[12] Ibrahim, Seham A., Eman A. Fayed, Hala F. Rizk, Said E. Desouky, and Ahmed Ragab. "Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl carbazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA." Bioorganic chemistry 116 (2021): 1053-69.
[13] Alnufaie, Rawan, Hansa Raj KC, Nickolas Alsup, Jedidiah Whitt, Steven Andrew Chambers, David Gilmore, and Mohammad A. Alam. "Synthesis and antimicrobial studies of coumarin-substituted carbazole derivatives as potent anti-Staphylococcus aureus agents." Molecules 25, no. 12 (2020): 2758.
[14] Abdellatif, Khaled RA, Eman KA Abdelall, Phoebe F. Lamie, Madlen B. Labib, El-Shaymaa El-Nahaas, and Marwa M. Abdelhakeem. "New carbazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies." Bioorganic chemistry 95 (2020): 1035-40.
How to cite this paper
@article{1717424,
author = {Bushra Taj, Santosh Kumar Shukla},
title = {Synthesis, Characterization and Antimic6 Activity of Some Pyrazole Derivative},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {9},
number = {11},
pages = {758-762},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1717424.pdf},
abstract = {Objective: The present study aimed to evaluate the antibacterial activity of different Pyrazole derivatives (4A–E) and screened against selected pathogenic microorganisms and to compare their efficacy with a standard antibiotic.
Materials and Methods: The antibacterial activity of the developed formulations was assessed against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus using the zone of inhibition method. The results were compared with the standard drug tetracycline to determine relative efficacy.
Results: Among all formulations, 5B and 5C demonstrated the highest antibacterial activity, exhibiting significant zones of inhibition against all tested microorganisms. Strong activity was particularly observed against Pseudomonas aeruginosa and Staphylococcus aureus, indicating broad-spectrum effectiveness. Other formulations showed moderate to low activity, while some exhibited no inhibition against Klebsiella pneumoniae.},
keywords = {Antibacterial, Pyrazole, Klebsiella Pneumoniae.},
month = {May},
doi = {https://doi.org/10.64388/IREV9I11-1717424}
}