Current Volume 9
Protective Effect of Methanol Extract of Oxymitra Longipedicellata Leaf Against Cadmium Chloride-Induced Testicotoxicity in Male Rats
Abstract
The aim and objective of this study is to evaluate the protective effect of methanol leaf extract of Oxymitra longipedicellata against Cadmium chloride-induced testiculotoxicity in male rats. Acute toxicity (LD₅₀) assessment revealed that the extract is relatively safe at lower doses, with toxic effects observed at higher concentrations (3000–5000 mg/kg). Forty-nine male Wistar rats were divided into seven groups and treated with cadmium chloride (2.5 mg/kg), extract (200 and 400 mg/kg), and quercetin (50 mg/kg) for 30 days. Cadmium exposure significantly (P < 0.05) reduced reproductive hormones (testosterone, FSH, LH), impaired sperm parameters, induced dyslipidemia, elevated liver enzymes, and disrupted antioxidant status, evidenced by decreased SOD, GST, and GSH levels alongside increased malondialdehyde (MDA). However, treatment with the extract significantly ameliorated these alterations in a dose-dependent manner. Notably, the 400 mg/kg dose restored hormonal balance, improved sperm quality, normalized lipid profile, reduced hepatotoxic markers, and enhanced antioxidant defense systems. The extract’s effects were comparable to or slightly better than quercetin in some parameters. These findings suggest that Oxymitra longipedicellata methanol leaf extract exerts significant protective effects against cadmium-induced reproductive and oxidative damage, likely via its antioxidant and free radical scavenging properties. The study highlights its potential as a natural therapeutic agent for managing heavy metal-induced testiculotoxicity.
Keywords
Cadmium toxicity, Oxymitra longipedicellata, Testiculotoxicity, Antioxidant, Reproductive hormones, Oxidative stress, Male fertility.
Citations
IRE Journals:
Ani Abosede Oluwakemi, Nwaemeke, David Iweunor, Lawal Semiu Olasoju "Protective Effect of Methanol Extract of Oxymitra Longipedicellata Leaf Against Cadmium Chloride-Induced Testicotoxicity in Male Rats" Iconic Research And Engineering Journals Volume 9 Issue 11 2026 Page 1884-1894
IEEE:
Ani Abosede Oluwakemi, Nwaemeke, David Iweunor, Lawal Semiu Olasoju
"Protective Effect of Methanol Extract of Oxymitra Longipedicellata Leaf Against Cadmium Chloride-Induced Testicotoxicity in Male Rats" Iconic Research And Engineering Journals, 9(11)
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