Formulation And Development of Polyherbal Effervescent Granules for The Treatment of Inflammatory Bowel Disease

References

[1] Mishra, Vinod, et al. “Wet and Dry Granulation: Comparative Study in Herbal Formulations.” European Journal of Pharmaceutical Sciences, vol. 178, 2023, 106229.

[2] Patel, Bhavesh, et al. “Formulation and Evaluation of Herbal Effervescent Granules Containing Withania Coagulans Extract.” Asian Journal of Pharmaceutical Sciences, vol. 18, no. 2, 2023, pp. 118–127.

[3] Prasad, Radha, et al. “Herbal Medicine: Current Applications and Future Prospects.” Medicinal Plant Research, vol. 16, no. 3, 2025, pp. 87–95.

[4] Raut, Roshan, and Vijay Kumar. “Phytochemical and Pharmacological Profile of Picrorhiza kurroa.” Journal of Ethnopharmacology, vol. 271, 2023, 113833.

[5] Saleh, Ahmed A., et al. “Development and Evaluation of Effervescent Tablets Containing Herbal Extracts.” Journal of Pharmaceutical Innovation, vol. 18, no. 2, 2024, pp. 215–224.

[6] Sharma, Deepak, et al. “Chemical Standardization and Quality Control of Herbal Medicine: Challenges and Solutions.” Phytochemistry Reviews, vol. 21, no. 1, 2023, pp. 31–49.

[7] Singh, S., et al. “Recent Advances in Effervescent Granules: Manufacturing Techniques and Quality Evaluation.” Pharmacognosy Reviews, vol. 16, no. 31, 2024, pp. 20–30.

[8] Tomar, Rachna, et al. “Anti-diabetic Potential and Safety Profile of Withania Coagulans: Preclinical Evidence.” Frontiers in Pharmacology, vol. 14, 2023, 1125938.

[9] Tripathi, Sneha, and Rahul Mehta. “Quality Control and Standardization of Herbal Extracts: Current Status.” Pharmaceutical Biology, vol. 60, sup. 1, 2023, pp. 5–15.

[10] Verma, Sanjay, et al. “Preparation and Physicochemical Evaluation of Herbal Effervescent Granules.” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 15, no. 1, 2023, pp. 124–130.

[11] Rudbaek JJ, Agrawal M, Jess T. Deciphering the different phases of preclinical inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2023.

[12] Waghchoure, K. (2023). A review on effervescent tablets: formulation and evaluation. International Journal of Pharmaceutical Research and Analysis, 8(1), 1246-1255.

[13] Zalte, A. J., & Surawase, R. K. (2024). Formulation and evaluation of metronidazole effervescent granules. Asian Journal of Pharmaceutical Research, 14(4), 340-345.

[14] Khandekar, S., Pansare, T., Pachpor, A., & Maurya, S. K. (2019). Pharmaceutical potential of effervescent granules. Biomedical Journal of Scientific & Technical Research, 20(5).

[15] Sharma, G. S., Batchan, H., & Rama Rao, T. (2025). Fundamental principles of effervescent granules: A review. International Journal of Pharmacy and Research, 3(6), 1700-1710.

[16] Patel, R. P., Patel, M. M., & Patel, K. S. (2009). Formulation and evaluation of effervescent granules. International Journal of Pharmaceutical Sciences and Research, 1(3), 45–50.

[17] Mukherjee, P. K., Venkatesh, M., & Kumar, V. (2007). An overview on the development in regulation and control of medicinal and aromatic plants in the Indian system. Journal of Herbal Medicine, 1(2), 25–32.

[18] Fabricant, D. S., & Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives, 109(S1), 69–

[19] Bhusnure, O. G., Gholve, S. B., Giram, P. S., & Giram, S. R. (2014). Formulation and evaluation of effervescent granules of herbal drug. International Journal of Pharmaceutical Sciences Review and Research, 28(2), 90–95.

@article{1717614,
      author = {Subodh Kumar, Hakim Singh Rajput, Dr. Amresh Gupta},
      title = {Formulation And Development of Polyherbal Effervescent Granules for The Treatment of Inflammatory Bowel Disease},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {11},
      pages = {660-663},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1717614.pdf},
      abstract = {Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, primarily including Crohn’s disease and Ulcerative colitis. The present study aims to formulate and evaluate polyherbal effervescent granules using extracts of Bauhinia variegata and Clitoria ternatea. These plants possess significant anti-inflammatory, antioxidant, and immunomodulatory properties. Effervescent granules were prepared using the wet granulation method and evaluated for physicochemical parameters such as flow properties, effervescence time, pH, and stability. The results indicated that the formulation exhibited good flow properties, rapid effervescence, and acceptable stability. The study concludes that the developed formulation may serve as a promising herbal alternative for managing IBD.},
      keywords = {Polyherbal Formulation, Effervescent Granules, Kachnar, And Aparajita.},
      month = {May},
      doi = {https://doi.org/10.64388/IREV9I11-1717614}
  }