Development Of Hydrogels with Self-Healing Properties for Delivery of Bioactive Agents: A Compressive Review

References

[1] Lai, W. F. (2021). Development of hydrogels with self-healing properties for delivery of bioactive agents. Molecular Pharmaceutics, 18(5), 1833–1841.

[2] Rumon, M. M. H., et al. (2022). Self-healing hydrogels: Development, biomedical applications, and challenges. Polymers, 14(21), 4539.

[3] Devi, A. V. K., et al. (2021). Self-healing hydrogels: Preparation, mechanism and advancement in biomedical applications. Polymers, 13(21), 3782.

[4] Xu, J., & Hsu, S. H. (2023). Self-healing hydrogel as an injectable implant: Translation in brain diseases. Journal of Biomedical Science, 30, 43.

[5] European Polymer Journal (2022). Autonomous self-healing hydrogels: Fabrication strategies and mechanisms.

[6] Peppas N. A., Huang, Y., & Torres-Lugo, M. (2000). Physicochemical foundations and structural design of hydrogels in medicine and biology. Annual Review of Biomedical Engineering, 2, 9–29.

[7] Caló E., & Khutoryanskiy, V. V. (2015). Biomedical applications of hydrogels: A review of patents and commercial products. European Polymer Journal, 65, 252–267.

[8] Li J., & Mooney, D. J. (2016). Designing hydrogels for controlled drug delivery. Nature Reviews Materials, 1(12), 16071.

[9] Zhao X. (2014). Multi-scale multi-mechanism design of tough hydrogels: Building dissipation into stretchy networks. Soft Matter, 10, 672–687.

[10] Wei Z., Yang, J. H., Du, X. J., Xu, F., & Zrinyi, M. (2015). Self-healing gels based on constitutional dynamic chemistry and their potential applications. Chemical Society Reviews, 44(3), 811–838.

[11] Sun T. L., Kurokawa, T., Kuroda, S., Ihsan, A. B., et al. (2013). Physical hydrogels composed of polyampholytes demonstrate high toughness and self-healing properties. Nature Materials, 12, 932–937.

[12] Cordier P., Tournilhac, F., Soulie-Ziakovic, C., & Leibler, L. (2008). Self-healing and thermoreversible rubber from supramolecular assembly. Nature, 451, 977–980.

[13] Appel E. A., et al. (2015). Supramolecular polymeric hydrogels for biomedical applications. Chemical Society Reviews, 44, 5875–5890.

[14] Hoare T. R., & Kohane, D. S. (2008). Hydrogels in drug delivery: Progress and challenges. Polymer, 49(8), 1993–2007.

[15] Gao Y., & Matyjaszewski, K. (2020). Self-healing polymers via dynamic covalent bonds. Progress in Polymer Science, 109, 101311.

[16] Zhang Y. S., & Khademhosseini, A. (2017). Advances in engineering hydrogels. Science, 356(6337), eaaf3627.

[17] Yu F., et al. (2021). Injectable self-healing hydrogels for tissue engineering and regenerative medicine. Acta Biomaterialia, 120, 1–13.

[18] Drury J. L., & Mooney, D. J. (2003). Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials, 24(24), 4337–4351.

[19] Ahmed E. M. (2015). Hydrogel: Preparation, characterization, and applications. Journal of Advanced Research, 6(2), 105–121.

[20] Buwalda S. J., et al. (2014). Hydrogels in a historical perspective: From simple networks to smart materials. Journal of Controlled Release, 190, 254–273.

@article{1717616,
      author = {Amandip Kumar Singh, Arun Kumar, Dr. Amresh Gupta, Hakim Singh Rajput},
      title = {Development Of Hydrogels with Self-Healing Properties for Delivery of Bioactive Agents: A Compressive Review},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {11},
      pages = {664-667},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1717616.pdf},
      abstract = {Hydrogels are three-dimensional polymeric networks capable of retaining large amounts of water, making them highly suitable for biomedical applications. However, conventional hydrogels suffer from poor mechanical strength and structural instability. The incorporation of self-healing properties into hydrogels has emerged as a promising strategy to overcome these limitations. Self-healing hydrogels possess the ability to autonomously repair structural damage through dynamic reversible interactions. These systems are particularly advantageous for the controlled delivery of bioactive agents such as drugs, proteins, and growth factors. This paper focuses on the design, mechanisms, formulation strategies, characterization, and applications of self-healing hydrogels in bioactive agent delivery.},
      keywords = {Self-Healing Hydrogel, Bioactive Agents, Drug Delivery, Dynamic Crosslinking, Polymer Networks, Biomedical Applications},
      month = {May},
      doi = {https://doi.org/10.64388/IREV9I11-1717616}
  }