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Formulation And Evaluation of Polyherbal Oral Disintegrating Tablet for The Treatment of Hypertension: A Comprehensive Review
Subject area: Biological & Medical Sciences · Area of research: Pharmacy
DOI: https://doi.org/10.64388/IREV9I11-1717728
Abstract
Hypertension is a chronic cardiovascular disorder characterized by elevated blood pressure and is considered one of the leading causes of mortality worldwide. Conventional antihypertensive drugs are effective but are often associated with adverse effects such as dizziness, fatigue, electrolyte imbalance, and poor patient compliance. Herbal medicines have gained increasing attention due to their natural origin, safety, and therapeutic efficacy. The present review focuses on the formulation and evaluation of polyherbal oral disintegrating tablets (ODTs) using Terminalia arjuna bark and Withania somnifera root for the management of hypertension. Terminalia arjuna possesses cardioprotective, antioxidant, anti-inflammatory, and antihypertensive properties, while Withania somnifera exhibits adaptogenic, anti-stress, and cardiotonic activities. Oral disintegrating tablets are advantageous because they disintegrate rapidly in saliva without water, improving patient compliance, especially in geriatric patients. This review discusses hypertension, herbal management, phytochemistry, formulation methods, evaluation parameters, mechanisms of action, and future prospects of polyherbal ODTs.
Keywords
Hypertension, Polyherbal formulation, Oral disintegrating tablets (ODTs), Terminalia arjuna, Herbal medicine, Superdisintegrants
How to cite this paper
@article{1717728,
author = {Varun Mishra, Hakim Singh Rajput, Dr. Amresh Gupta, Arun Kumar},
title = {Formulation And Evaluation of Polyherbal Oral Disintegrating Tablet for The Treatment of Hypertension: A Comprehensive Review},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {9},
number = {11},
pages = {1197-1204},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1717728.pdf},
abstract = {Hypertension is a chronic cardiovascular disorder characterized by elevated blood pressure and is considered one of the leading causes of mortality worldwide. Conventional antihypertensive drugs are effective but are often associated with adverse effects such as dizziness, fatigue, electrolyte imbalance, and poor patient compliance. Herbal medicines have gained increasing attention due to their natural origin, safety, and therapeutic efficacy. The present review focuses on the formulation and evaluation of polyherbal oral disintegrating tablets (ODTs) using Terminalia arjuna bark and Withania somnifera root for the management of hypertension. Terminalia arjuna possesses cardioprotective, antioxidant, anti-inflammatory, and antihypertensive properties, while Withania somnifera exhibits adaptogenic, anti-stress, and cardiotonic activities. Oral disintegrating tablets are advantageous because they disintegrate rapidly in saliva without water, improving patient compliance, especially in geriatric patients. This review discusses hypertension, herbal management, phytochemistry, formulation methods, evaluation parameters, mechanisms of action, and future prospects of polyherbal ODTs.},
keywords = {Hypertension, Polyherbal formulation, Oral disintegrating tablets (ODTs), Terminalia arjuna, Herbal medicine, Superdisintegrants},
month = {May},
doi = {https://doi.org/10.64388/IREV9I11-1717728}
}