Oral Fast Dissolving Films of Promethazine Hydrochloride Using Natural Surfactants: Formulation Strategies, Evaluation, and Therapeutic Perspectives

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@article{1718193,
      author = {Abhishek Maurya, Vaibhav Singh},
      title = {Oral Fast Dissolving Films of Promethazine Hydrochloride Using Natural Surfactants: Formulation Strategies, Evaluation, and Therapeutic Perspectives},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {11},
      pages = {3286-3290},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1718193.pdf},
      abstract = {Oral fast dissolving films (OFDFs) have emerged as a patient-centric drug delivery platform designed to overcome limitations associated with conventional oral dosage forms. These thin polymeric films rapidly disintegrate in the oral cavity without the need for water, offering rapid onset of action, improved bioavailability, and enhanced patient compliance, particularly in pediatric, geriatric, and dysphagic populations. Promethazine hydrochloride, a first-generation antihistamine with potent antiemetic activity, is widely used in the management of nausea, vomiting, motion sickness, and allergic conditions; however, its conventional formulations suffer from delayed onset, first-pass metabolism, and palatability issues. This review critically examines the formulation and evaluation of OFDFs of promethazine hydrochloride with special emphasis on the application of natural surfactants. The article discusses formulation principles, selection of polymers and excipients, manufacturing techniques, physicomechanical and biopharmaceutical evaluation parameters, stability considerations, and regulatory perspectives. The potential advantages of natural surfactants over synthetic counterparts in terms of safety, biocompatibility, and sustainability are highlighted. Current challenges, future prospects, and translational opportunities of OFDF technology for promethazine hydrochloride are also addressed.},
      keywords = {Oral Fast Dissolving Films, Promethazine Hydrochloride, Natural Surfactants, Solvent Casting, Patient Compliance, Bioavailability},
      month = {May},
      doi = {https://doi.org/10.64388/IREV9I11-1718193}
  }