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Pharmacological Profiling and In-Vitro Antimicrobial Activity of Eurycoma Longifolia Jack (Tongkat Ali): A Comprehensive Review
Subject area: Biological & Medical Sciences · Area of research: Pharmacological Profiling
DOI: https://doi.org/10.64388/IREV9I11-1718195
Abstract
The rapid escalation of antimicrobial resistance and the associated decline in the effectiveness of conventional antibiotics have intensified the global search for alternative therapeutic agents derived from natural sources. Medicinal plants continue to serve as valuable reservoirs of structurally diverse bioactive compounds with broad pharmacological potential. Eurycoma longifolia Jack (family: Simaroubaceae), commonly known as Tongkat Ali, is a traditional medicinal plant indigenous to Southeast Asia and widely used for the treatment of fever, infections, malaria, fatigue, and sexual dysfunction. Although the aphrodisiac and antimalarial properties of E. longifolia are well established, increasing experimental evidence suggests significant antimicrobial activity against a variety of bacterial and fungal pathogens. This review critically compiles and evaluates published literature on the phytochemical composition, pharmacological properties, and in-vitro antimicrobial activity of Eurycoma longifolia. Emphasis is placed on studies conducted by different researchers, extraction strategies, experimental methodologies, antimicrobial efficacy against Gram-positive and Gram-negative bacteria as well as pathogenic fungi, and proposed mechanisms of action. Challenges related to standardization, reproducibility, and clinical translation are discussed. Overall, E. longifolia emerges as a promising natural source of antimicrobial agents with potential applications in combating drug-resistant infections.
Keywords
Eurycoma Longifolia, Tongkat Ali, Antimicrobial Activity, Phytochemistry, Quassinoids, Medicinal Plants
How to cite this paper
@article{1718195,
author = {Shikha Pandey, Prashant Kumar Singh, Debabrata Lahiry},
title = {Pharmacological Profiling and In-Vitro Antimicrobial Activity of Eurycoma Longifolia Jack (Tongkat Ali): A Comprehensive Review},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {9},
number = {11},
pages = {3296-3299},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1718195.pdf},
abstract = {The rapid escalation of antimicrobial resistance and the associated decline in the effectiveness of conventional antibiotics have intensified the global search for alternative therapeutic agents derived from natural sources. Medicinal plants continue to serve as valuable reservoirs of structurally diverse bioactive compounds with broad pharmacological potential. Eurycoma longifolia Jack (family: Simaroubaceae), commonly known as Tongkat Ali, is a traditional medicinal plant indigenous to Southeast Asia and widely used for the treatment of fever, infections, malaria, fatigue, and sexual dysfunction. Although the aphrodisiac and antimalarial properties of E. longifolia are well established, increasing experimental evidence suggests significant antimicrobial activity against a variety of bacterial and fungal pathogens. This review critically compiles and evaluates published literature on the phytochemical composition, pharmacological properties, and in-vitro antimicrobial activity of Eurycoma longifolia. Emphasis is placed on studies conducted by different researchers, extraction strategies, experimental methodologies, antimicrobial efficacy against Gram-positive and Gram-negative bacteria as well as pathogenic fungi, and proposed mechanisms of action. Challenges related to standardization, reproducibility, and clinical translation are discussed. Overall, E. longifolia emerges as a promising natural source of antimicrobial agents with potential applications in combating drug-resistant infections.},
keywords = {Eurycoma Longifolia, Tongkat Ali, Antimicrobial Activity, Phytochemistry, Quassinoids, Medicinal Plants},
month = {May},
doi = {https://doi.org/10.64388/IREV9I11-1718195}
}