Current Volume 9
Lipid-Modulating Effects of C. argentea in Phenylhydrazine-Induced Dyslipidaemia: Implications for Cardiovascular Risk
Abstract
Phenylhydrazine-induced haemolytic anaemia is associated with oxidative disruption of hepatic lipid metabolism, leading to a pro-atherogenic dyslipidaemia characterized by elevated levels of total cholesterol (TC), LDL cholesterol, and triglycerides (TG), with concomitant suppression of cardioprotective HDL cholesterol. Celosia argentea is a nutritious green vegetable with reported antioxidant and anti-inflammatory activity. However, its lipid-regulatory effects under PHZ-induced oxidative dyslipidaemia have not been thoroughly explored. The present work aimed to examine the lipid-modifying property of aqueous leaf extract of C. argentea in PHZ, which caused dyslipidaemia in Wistar rats. Sixty adult male Wistar rats were divided into six groups (n = 10). PHZ (50 mg/kg) was administered intraperitoneally for 3 consecutive days to produce dyslipidaemia. Standard enzymatic colourimetric techniques were used to measure serum TC, TG, HDL-C, and LDL-C. The results showed that PHZ significantly increased the levels of TC (105.33 ± 5.03 mg/dl), LDL-C (55.00 ± 3.00 mg/dl) and decreased HDL-C (32.67 ± 2.87 mg/dl) as compared to controls (TC: 66.00 ± 11.38; LDL-C: 16.25 ± 3.20; HDL-C: 37.40 ± 2.51 mg/dl; p < 0.05). C. argentea post-treatment considerably lowered TC (71.00 ± 7.81 mg/dl), and LDL-C (38.67 ± 0.58 mg/dl), and partially restored HDL-C (35.75 ± 2.06 mg/dl) levels, which were comparable to Vitamin C. Pre-treatment also showed substantial activity in lipid normalization. The study showed that the aqueous leaf extract of C. argentea had significant lipid-modulating effects in PHZ-induced dyslipidaemia through antioxidant, cholesterol absorption-inhibiting, and hepatic lipid-regulatory pathways. The results provide a scientific basis for considering C. argentea as a plant-based nutraceutical supplement for the control of cardiovascular risk.
Keywords
Celosia argentea, dyslipidaemia, phenylhydrazine, total cholesterol, LDL cholesterol, HDL cholesterol
Citations
IRE Journals:
Ajikobi Raphael Ayodeji, Oludiran Josuha Isaac "Lipid-Modulating Effects of C. argentea in Phenylhydrazine-Induced Dyslipidaemia: Implications for Cardiovascular Risk" Iconic Research And Engineering Journals Volume 9 Issue 12 2026 Page 241-249 https://doi.org/10.64388/IREV9I12-1718568
IEEE:
Ajikobi Raphael Ayodeji, Oludiran Josuha Isaac
"Lipid-Modulating Effects of C. argentea in Phenylhydrazine-Induced Dyslipidaemia: Implications for Cardiovascular Risk" Iconic Research And Engineering Journals, 9(12) https://doi.org/10.64388/IREV9I12-1718568
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