Current Volume 9
Formulation and Evaluation of Herbal Transdermal Patch of Clerodendrum Infortunatum for Anti-Inflammatory Activity
Abstract
Transdermal drug delivery systems (TDDS) represent a modern approach for delivering therapeutic agents through the skin into the systemic circulation, offering significant advantages including avoidance of first-pass metabolism, controlled drug release, improved bioavailability, and enhanced patient compliance. Clerodendrum infortunatum Linn. (Family: Lamiaceae), commonly known as Bhat or Bhant, is a well-known medicinal plant with significant anti-inflammatory, antibacterial, antifungal, and wound-healing properties. Its active phytoconstituents — including flavonoids, terpenoids, alkaloids, and steroids — make it a potential candidate for topical and transdermal applications, particularly for skin disorders such as eczema, dermatitis, and inflammatory conditions. The present study aimed to formulate and evaluate transdermal herbal patches of C. infortunatum leaf extract by solvent casting technique using polymers HPMC and PVA. Three formulations (F1, F2, F3) were developed with varying drug concentrations. The patches were evaluated for physical appearance, thickness, weight uniformity, folding endurance, moisture content, moisture uptake, flatness, drug content uniformity, in vitro drug permeation using Franz diffusion cell, skin irritation test, and stability studies. Phytochemical screening confirmed the presence of flavonoids, alkaloids, tannins, steroids, and phenolic compounds. Formulation F2 (HPMC:PVA = 2:3) exhibited the best overall performance, with drug content of 97.8%, folding endurance of 225, and cumulative drug permeation of 91.2% in 8 hours following Higuchi diffusion kinetics. Skin irritation studies confirmed the patches were non-irritant. Stability studies showed no significant changes at room temperature over 4 weeks.
Keywords
Anti-Inflammatory, Clerodendrum Infortunatum, Herbal Transdermal Patch, HPMC, In Vitro Drug Release, PVA, Phytochemical Screening, Solvent Casting
Citations
IRE Journals:
Mayur R. Bawankar, Pravin Karatkar, Tanmay Patle, Darshan Rathod, Krishna Kukreja "Formulation and Evaluation of Herbal Transdermal Patch of Clerodendrum Infortunatum for Anti-Inflammatory Activity" Iconic Research And Engineering Journals Volume 9 Issue 12 2026 Page 1296-1301 https://doi.org/10.64388/IREV9I12-1718742
IEEE:
Mayur R. Bawankar, Pravin Karatkar, Tanmay Patle, Darshan Rathod, Krishna Kukreja
"Formulation and Evaluation of Herbal Transdermal Patch of Clerodendrum Infortunatum for Anti-Inflammatory Activity" Iconic Research And Engineering Journals, 9(12) https://doi.org/10.64388/IREV9I12-1718742
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
Important Links
For Authors
Volume 8:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 7:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 6:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 5:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 4:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 3:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12