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Formulation and Evaluation of Trachyspermum Ammi Oil Roll-On for Migraine Relife
Subject area: Biological & Medical Sciences · Area of research: Trachyspermum Ammi Oil Roll-On
DOI: https://doi.org/10.64388/IREV10I1-1719465
Abstract
Migraine headaches can be debilitating, significantly impacting quality of life. This study investigates the development and evaluation of a topical herbal roll-on formulation designed for the rapid relief of migraine symptoms. Herbal roll-ons are natural liquid preparations containing essential volatile oils and herbal extracts used to relieve pain and stress in migraines. Literature review and studies reveal that essential oils such as camphor, eucalyptus, lavender, and peppermint, along with herbal extracts like Ajwain, is commonly used in migraine treatment. This roll-on format offers a convenient and non-invasive alternative to traditional oral medications, providing targeted delivery of these active herbal ingredients Ajwain as key ingredients. Ajwain is known for its potential to reduce migraine frequency and intensity through anti-inflammatory and analgesic actions. Eucalyptus oil provides calming effects, helping to mitigate stress and anxiety, common migraine triggers. Together, they aim to alleviate pain and discomfort associated with migraines. The roll-on was evaluated for its physicochemical properties, including viscosity, Spreadability, and stability. In vitro drug release studies were conducted to assess the rate and extent of active ingredient permeation. The results demonstrate that the developed roll-on formulation exhibits desirable physicochemical characteristics and provides sustained release of active ingredients This topical herbal roll-on presents a promising option for the on-demand relief of migraine symptoms, offering a practical and patient-friendly approach.
Keywords
Aromatherapy, Natural relief, Essential oils, Headache Management.
References
[1] Pawar et al. “Preparation and Evaluation of Herbal-Roll on For the Management of Migraine”, International Journal of Creative Research Thoughts (IJCRT), November 2025, page no. g47.
[2] Heydarirad et al “Exploring the Effectiveness of Ajwain Cream in Treating Taxane-induced Peripheral Neuropathy in Cancer Patients: A Pilot, Randomised and Double-blind Clinical Trial”, Indian Journal of Palliative Care, 2024, page no. 71-76.
[3] P.A Lingaya, et al. “Formulation and evaluation Herbal roll on used in headache”, International Journal of Scientific Research and Development (IJSRD), 2024, page no. 144.
[4] Padmaja Kota et al. “Formulation and Evaluation of Pain relief Herbal roll on,”
[5] World Journal of Pharmaceutical Sciences (WJPS), 2022, page no. 52-55.
[6] Ruyifang yan, et al. “Review of aromatherapy essential oils and their mechanism of action against migraines,” Journal of Ethanopharmacology, 2020, page no. 1-17.
[7] Himadhari Sharma et al. “Pharmaceutical and Cosmetic Approach to Skin Barrier Repair,” International Journal of Creative Research Thoughts (IJCRT), 2025, published paper ID: IJCRT2504182.
[8] Furqan, M., Ghatode, V., & Heerakaremore. “Formulation and Evaluation of a Herbal Roll-on for Pain Relief”. International Journal of Innovative Science and Research Technology, (2025) 10(3), 2472–2474. ISSN 2456-2165.
[9] Ankit Kushwaha and Dr. Vandna Pathak, “Phytochemical and Physicochemical Study of Ajwain Seeds (Trachyspermum ammi.),” International Journal of Novel Research and Development (IJNRD), July 2024, Volume 9, Issue 7, ISSN: 2456-4184, page no. f109–f130.
[10] Shilpa Debnath et al., “An Insight of Trachyspermum ammi L.: A Comprehensive Review on Its Aromatic and Medicinal Potential,” Annals of Phytomedicine, 2022, Volume 11, Issue 2, pp. [210-2218].
[11] Himani Singh et al., “Ajwain: A Potential Source of Phytochemical for Better Health,” The Pharma Innovation Journal, 2019, Volume 8, Issue 6, Part K, pp. 122–127.
[12] K.R. Khandelwal. “Practical Pharmacognosy: Techniques and Experiments”, Nirali Prakashan, 2008 (19th edition), page no. 47.
How to cite this paper
@article{1719465,
author = {Ashwini G. Wanve, Jiya N. Jamkatan, Bharti L. Baghele, Himani M. Barewar, Suhani S. Jivtode; Trushna G. Golange},
title = {Formulation and Evaluation of Trachyspermum Ammi Oil Roll-On for Migraine Relife},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {10},
number = {1},
pages = {674-687},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1719465.pdf},
abstract = {Migraine headaches can be debilitating, significantly impacting quality of life. This study investigates the development and evaluation of a topical herbal roll-on formulation designed for the rapid relief of migraine symptoms. Herbal roll-ons are natural liquid preparations containing essential volatile oils and herbal extracts used to relieve pain and stress in migraines. Literature review and studies reveal that essential oils such as camphor, eucalyptus, lavender, and peppermint, along with herbal extracts like Ajwain, is commonly used in migraine treatment. This roll-on format offers a convenient and non-invasive alternative to traditional oral medications, providing targeted delivery of these active herbal ingredients Ajwain as key ingredients. Ajwain is known for its potential to reduce migraine frequency and intensity through anti-inflammatory and analgesic actions. Eucalyptus oil provides calming effects, helping to mitigate stress and anxiety, common migraine triggers. Together, they aim to alleviate pain and discomfort associated with migraines. The roll-on was evaluated for its physicochemical properties, including viscosity, Spreadability, and stability. In vitro drug release studies were conducted to assess the rate and extent of active ingredient permeation. The results demonstrate that the developed roll-on formulation exhibits desirable physicochemical characteristics and provides sustained release of active ingredients This topical herbal roll-on presents a promising option for the on-demand relief of migraine symptoms, offering a practical and patient-friendly approach.},
keywords = {Aromatherapy, Natural relief, Essential oils, Headache Management.},
month = {July},
doi = {https://doi.org/10.64388/IREV10I1-1719465}
}