Evaluating the Impacts of Genotoxicity on Fish Health and Population Dynamics: A Review of Xenobiotic Stressors in Aquatic Ecosystems

References

[1] Aich, U., Polverino, G., Yazdan Parast, F., Melo, G. C., Tan, H., Howells, J., Nosrati, R., & Wong, B. B. M. (2025). Long-term effects of widespread pharmaceutical pollution on trade-offs between behavioural, life-history, and reproductive traits in fish. Journal of Animal Ecology, 94(3), 340–355. https://doi.org/10.1111/1365-2656.14152

[2] Ali, D., Almarzoug, M. H. A., Al Ali, H., Samdani, M. S., Hussain, S. A., & Alarifi, S. (2020). Fish as bio indicators to determine the effects of pollution in river by using the micronucleus and alkaline single cell gel electrophoresis assay. Journal of King Saud University – Science, 32(6), 2880–2885. https://doi.org/10.1016/j.jksus.2020.07.012

[3] Celino-Brady, F. T., Lerner, D. T., & Seale, A. P. (2021). Experimental approaches for characterizing the endocrine-disrupting effects of environmental chemicals in fish. Frontiers in Endocrinology, 11, 619361. https://doi.org/10.3389/fendo.2020.619361

[4] Dalzochio, T., Rodrigues, G. Z. P., Petry, I. E., Gehlen, G., & Silva, L. B. (2016). The use of biomarkers to assess the health of aquatic ecosystems in Brazil: A review. International Aquatic Research, 8, 283–298. https://doi.org/10.1007/s40071-016-0147-9

[5] Dasmahapatra, A. K., Williams, C. B., Myla, A. M., Tiwary, S. K., & Tchounwou, P. B. (2023). A systematic review of the evaluation of endocrine-disrupting chemicals in the Japanese medaka (Oryzias latipes) fish. Frontiers in Toxicology, 5, 1272368. https://doi.org/10.3389/ftox.2023.1272368

[6] Dey, A., Manna, S., & Dey, S. K. (2023). DNA repair genes play a variety of roles in the development of fish embryos. Frontiers in Cell and Developmental Biology, 11, 1119229. https://doi.org/10.3389/fcell.2023.1119229

[7] Drąg-Kozak, E., Kuchta-Gładysz, M., Grzesiakowska, A., Łuszczek-Trojnar, E., & Socha, M. (2022). Genotoxic effect of cadmium and zinc in the peripheral erythrocytes of Prussian carp (Carassius gibelio B.). Journal of Veterinary Research, 66(4), 619–628. https://doi.org/10.2478/jvetres-2022-0057

[8] Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017). Pharmaceuticals and personal care products in the freshwater aquatic environment. Emerging Contaminants, 3(1), 1–16. https://doi.org/10.1016/j.emcon.2016.12.004

[9] Ferrari, R. (2015). Writing narrative style literature reviews. Medical Writing, 24(4), 230–235. https://doi.org/10.1179/2047480615Z.000000000329

[10] Ghafarifarsani, H., Rohani, M. F., Raeeszadeh, M., Ahani, S., Yousefi, M., Talebi, M., & Hossain, M. S. (2024). Pesticides and heavy metal toxicity in fish and possible remediation: A review. Annals of Animal Science, 24(4), 1009–1028. https://doi.org/10.2478/aoas-2024-0012

[11] Grădinariu, L., Crețu, M., Vizireanu, C., & Dediu, L. (2025). Oxidative stress biomarkers in fish exposed to environmental concentrations of pharmaceutical pollutants: A review. Biology, 14(5), 472. https://doi.org/10.3390/biology14050472

[12] Hussain, B., Sultana, T., Sultana, S., Masoud, M. S., Ahmed, Z., & Mahboob, S. (2018). Fish eco-genotoxicology: Comet and micronucleus assay in fish erythrocytes as in situ biomarker of freshwater pollution. Saudi Journal of Biological Sciences, 25(2), 393–398. https://doi.org/10.1016/j.sjbs.2017.11.048

[13] Kroon, F. J., Streten, C., & Harries, S. (2017). A protocol for identifying suitable biomarkers to assess fish health: A systematic review. PLOS ONE, 12(4), e0174762. https://doi.org/10.1371/journal.pone.0174762

[14] Li, X., Naseem, S., Hussain, R., Ghaffar, A., Li, K., & Khan, A. (2022). Evaluation of DNA damage, biomarkers of oxidative stress, and status of antioxidant enzymes in freshwater fish (Labeo rohita) exposed to pyriproxyfen. Oxidative Medicine and Cellular Longevity, 2022, 5859266. https://doi.org/10.1155/2022/5859266

[15] Matthiessen, P. (2018). A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations. Critical Reviews in Toxicology, 48(3), 195–216. https://doi.org/10.1080/10408444.2017.1397099

[16] Miller, M. E., Hamann, M., & Kroon, F. J. (2020). Bioaccumulation and biomagnification of microplastics in marine organisms: A review and meta-analysis of current data. PLOS ONE, 15(10), e0240792. https://doi.org/10.1371/journal.pone.0240792

[17] Noman, M. A., Feng, W., Zhu, G., Hossain, M. B., Chen, Y., Zhang, H., & Sun, J. (2022). Bioaccumulation and potential human health risks of metals in commercially important fishes and shellfishes from Hangzhou Bay, China. Scientific Reports, 12, 4634. https://doi.org/10.1038/s41598-022-08471-y

[18] Okwet J. Y., Simeon R. U., Ita O. A., Anthony E. A, Usenobong B. A., Emaediong A. U. (2025). Estimating the Pollution Status and Toxicity of Heavy Metals in Water of Ukwuyok Drinking Stream of Okorombokho, Eastern Obolo, Southeastern Nigeria. Internanational Journal of Research Publication & Reviews.6(4):11843-11862.

[19] Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., et al. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

[20] Pironti, C., Ricciardi, M., Proto, A., Bianco, P. M., Montano, L., & Motta, O. (2021). Endocrine-disrupting compounds: An overview on their occurrence in the aquatic environment and human exposure. Water, 13(10), 1347. https://doi.org/10.3390/w13101347

[21] Ray, S., & Shaju, S. T. (2023). Bioaccumulation of pesticides in fish resulting toxicities in humans through food chain and forensic aspects. Environmental Analysis Health and Toxicology, 38(3), e2023017. https://doi.org/10.5620/eaht.2023017

[22] Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/j.jbusres.2019.07.039

[23] Ubulom, S. R., Akpan, U. E., Yawo, O. J., Essien, I, C., Edemumo, F. O., 2023. Evaluation of the Effects of Heavy Metals on Sediments and Rainwater Samples Due to Gas Flaring in the South Eastern Nigeria, , J. Glob. Ecol. Environ. 18(3): 1-16

[24] Ubulom, S. R., Ekanem, M. P., Etim, I. N., Yawo, O.J., & Ewa-Oboho, I. (2022). Assessment of Contamination Status of Heavy Metals in Sediment due to Gas Flaring at Esit Eket, South Eastern Nigeria, Researchers Journal of Science and Technology, 2(1): 50 -63

[25] Ubulom, S. R., Yawo, O. J., Akpan, U. E, 2023. Evaluating the Distributions and Impacts of Macroplastic Pollutants in Agansa Coastal Community, South Eastern Nigeria , J. Glob. Ecol. Environ. 18(2): 32-45

[26] Wilkinson, J. L., Boxall, A. B. A., Kolpin, D. W., Leung, K. M. Y., Lai, R. W. S., Galbán-Malagón, C., Adell, A. D., Mondon, J., Metian, M., Marchant, R. A., Bouzas-Monroy, A., Cuni-Sanchez, A., Coors, A., Carriquiriborde, P., Rojo, M., Gordon, C., Cara, M., Moermond, M., Luarte, T., et al. (2022). Pharmaceutical pollution of the world’s rivers. Proceedings of the National Academy of Sciences, 119(8), e2113947119. https://doi.org/10.1073/pnas.2113947119

[27] Yawo, O. J., Ubulom, S. R., Akpan, I. O., Nathaniel, E. U., Amodu, A. E., Azogor, W. E., 2023. Evaluating the Pollution Levels and Ecological Risks of Heavy Metals in Sediments of Apapa Port in Lagos, South-western Nigeria, J. Glob. Ecol. Environ. 19(2); 15-33

@article{1719556,
      author = {Isangedighi Asuquo Isangedighi, Simeon Reuben Ubulom, Okwet Joseph Yawo, Toyoabasi Ime Balogun, Udoh, Inemesit Amaitem; Essien, Idorenyin Chrysanthus; Unyime Anthony Inyang},
      title = {Evaluating the Impacts of Genotoxicity on Fish Health and Population Dynamics: A Review of Xenobiotic Stressors in Aquatic Ecosystems},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {10},
      number = {1},
      pages = {1927-1936},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1719556.pdf},
      abstract = {Aquatic ecosystems are increasingly threatened by xenobiotic pollutants released through agricultural runoff, industrial discharge, domestic wastewater, pharmaceutical residues and other human-related activities. These contaminants may persist in water bodies, accumulate in fish tissues and interfere with normal biological processes, including the integrity of genetic material. Fish are important indicators of aquatic ecosystem health because they are continuously exposed to contaminants through the gills, skin, sediments and food chain, making them useful organisms for assessing environmental pollution. This review examines the impacts of xenobiotic-induced genotoxicity on fish health and population dynamics, with emphasis on DNA damage, biomarkers of exposure, reproductive impairment, growth reduction, survival decline and ecosystem consequences. The article is based on a secondary-sourced narrative review of relevant literature on aquatic pollution, genotoxic mechanisms, fish toxicology, biomarkers and environmental management. Findings from reviewed studies indicate that xenobiotics such as pesticides, heavy metals, hydrocarbons, pharmaceuticals and endocrine-disrupting chemicals can cause DNA strand breaks, micronuclei formation, chromosomal abnormalities, oxidative stress and impaired DNA repair in fish. These effects may weaken immunity, reduce growth, affect reproductive performance, alter sex ratios, lower recruitment and contribute to population decline. The review concludes that genotoxicity should be treated not only as a cellular problem but also as an ecological and public health concern. Regular biomarker-based monitoring, improved wastewater treatment, stricter pollution control and effective enforcement of environmental regulations are recommended to protect fish populations, aquatic ecosystems and human health.},
      keywords = {Genotoxicity, Fish, Xenobiotics, Population dynamics, Aquatic pollution, Biomarkers},
      month = {July},
      doi = {https://doi.org/10.64388/IREV10I1-1719556}
  }