Formulation and Characterization of Nanostructured Lipid Carrier Loaded In Situ Intranasal Gel for Brain Delivery of Venlafaxine

References

[1] Nagalakshmi S, Kalaiapurmal K, Arul Jothy M, Chaudhari PS, Pushpalatha HB, Shanmuganthan S. Fabrication and Characterization of Herbal Drug –Loaded Nonionic Surfactant Based Niosomal Topical Gel. J Pharm Sci Res 2016; 8(11): 1271-1278

[2] Parhizkar M, Reardon PJT, Harker AH, Browning RJ, Stride E, Pedley RB, Knowles JC, Edirisinghe M. Enhanced efficacy in drug-resistant cancer cells through synergistic nanoparticle mediated delivery of cisplatin and decitabine. Nanoscale Adv 2020; 2: 1177-1186

[3] Jain, K. (2020). Drug Delivery Systems (3rd ed.). USA: Springer Science+Business Media, LLC.

[4] Tibbitt, M.W.; Dahlman, J.E.; Langer, R. Emerging frontiers in drug delivery. J. Am.

[5] Chem. Soc. 2016, 138, 704–717.

[6] Builders, P.F.; Arhewoh, M.I. Pharmaceutical applications of native starch in conventional drug delivery. Starch-Stärke 2016, 9–10, 864–873.

[7] Alshammari, M.K.; Alshehri, M.M.; Alshehri, A.M.; Alshlali, O.M.; Mahzari, A.M.; Almalki, H.H.; Kulaybi, O.Y.; Alghazwni, M.K.; Kamal, M.; Imran, M. Camptothecin loaded nano-delivery systems in the cancer therapeutic domains: A critical examination of the literature. J. Drug Deliv. Sci. Technol. 2022, 79, 104034.

[8] Lai, H.; Liu, S.; Yan, J.; Xing, F.; Xiao, P. Facile Fabrication of Biobased Hydrogel from Natural Resources: L-Cysteine, Itaconic Anhydride, and Chitosan. ACS Sustain. Chem. Eng. 2020, 8, 4941–4947.

[9] Marco-Dufort, B.; Willi, J.; Vielba-Gomez, F.; Gatti, F.; Tibbitt, M.W. Environment Controls Biomolecule Release from Dynamic Covalent Hydrogels. Biomacromolecules 2021, 22, 146–157.

[10] Prasad, R.D.; Charmode, N.; Shrivastav, O.P.; Prasad, S.R.; Moghe, A.; Sarvalkar, P.D.; Prasad, N.R. A review on concept of nanotechnology in veterinary medicine. ES Food Agrofor. 2021, 4, 28–60.

[11] Lateef, A.; Darwesh, O.M.; Matter, I.A. Microbial nanobiotechnology: The melting pot of microbiology, microbial technology and nanotechnology. In Microbial Nanobiotechnology; Springer: Singapore, 2021; pp. 1–19.

[12] Mansor, N.I.; Nordin, N.; Mohamed, F.; Ling, K.H.; Rosli, R.; Hassan, Z. Crossing the blood-brain barrier: A review on drug delivery strategies for treatment of the central nervous system diseases. Curr. Drug Deliv. 2019, 16, 698–711.

[13] Ajalli, N., Pourmadadi, M., Yazdian, F., Rashedi, H., Navaei-Nigjeh, M. and Díez-Pascual, A.M., 2022. Chitosan/Gamma-Alumina/Fe3O4@ 5-FU nanostructures as promising nanocarriers: physiochemical characterization and toxicity activity. Molecules, 27(17), p.5369.

[14] Ahmad, I., Khan, M.F.A., Rahdar, A., Hussain, S., Tareen, F.K., Salim, M.W., Ajalli, N., Amirzada, M.I. and Khan, A., 2022. Design and evaluation of pH sensitive PEG-protamine nanocomplex of doxorubicin for treatment of breast cancer. Polymers, 14(12), p.2403.

[15] Byeon, J.C., Ahn, J.B., Jang, W.S., Lee, S.E., Choi, J.S. and Park, J.S., 2019. Recent formulation approaches to oral delivery of herbal medicines. Journal of pharmaceutical investigation, 49, pp.17-26.

[16] Khan AA, Mudassir J, Mohtar N, Darwis, Y. Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. International journal of nanomedicine. 2013; 8: 2733.

[17] Jansson B, Hägerström H, Fransén N, Edsman K,Björk E.The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo. European Journal of Pharmaceutics and Biopharmaceutics. 2005; 59(3): 557-564.

[18] Hägerström H, Edsman K. Limitations of the rheological mucoadhesion method: the effect of the choice of conditions and the rheological synergism parameter. European Journal of Pharmaceutical Sciences. 2003; 18(5): 349-357.

[19] Mahajan, HS, Gattani SG. Gellan gum based microparticles of metoclopromide hydrochloride for intranasal delivery: development and evaluation. Chem Pharm Bull. 2009; 57(4): 388-392.

[20] Cao SL, Ren XW, Zhang QZ, Chen E, Xu F, Chen J, Liu LC, Jiang XG. In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate. Int J Pharmaceut. 2009; 365(1): 109-115.

@article{1719713,
      author = {Arti Dhakad, Dr. Pradeep Chauhan, Dr. Sandeep Jain, Dr. Bharat K. Tyagi},
      title = {Formulation and Characterization of Nanostructured Lipid Carrier Loaded In Situ Intranasal Gel for Brain Delivery of Venlafaxine},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {10},
      number = {1},
      pages = {956-964},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1719713.pdf},
      abstract = {Depression is a common neurological disorder that requires effective drug delivery to the brain for improved therapeutic outcomes. Venlafaxine, an antidepressant, exhibits limited brain availability due to extensive first-pass metabolism and the blood–brain barrier. The present study aims to formulate and characterize a venlafaxine-loaded nanostructured lipid carrier (NLC) incorporated into an in situ intranasal gel for direct nose-to-brain delivery. The NLCs are prepared using the hot homogenization–ultrasonication method and evaluated for particle size, polydispersity index, zeta potential, entrapment efficiency, and in vitro drug release. The optimized NLC formulation is incorporated into a thermosensitive in situ gel and assessed for pH, gelation temperature, viscosity, mucoadhesive strength, and ex vivo nasal permeation. The developed formulation is expected to enhance nasal residence time, improve brain targeting, provide sustained drug release, and increase the therapeutic efficacy of venlafaxine. Therefore, the proposed NLC-loaded in situ intranasal gel represents a promising and non-invasive strategy for efficient brain delivery of venlafaxine.},
      keywords = {Venlafaxine, Nanostructured Lipid Carrier, In Situ Gel, Intranasal Delivery, Brain Targeting, Mucoadhesion.},
      month = {July},
      doi = {https://doi.org/10.64388/IREV10I1-1719713}
  }