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1719732 Vol 10 · Issue 1 Download Paper

Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries

Itodo, I. N. ABEL, E. D. Esievo L. O.

Subject area: Physical Sciences and Environment  ·  Area of research: Organic Chemistry

DOI: https://doi.org/10.64388/IREV10I1-1719732

Abstract

The increasing demand for sustainable, biocompatible, and environmentally friendly materials has intensified research interest in naturally derived polysaccharides for industrial and biomedical applications. Among these biopolymers, alginate and hyaluronic acid have gained significant attention due to their remarkable physicochemical properties, biodegradability, non-toxicity, and versatile functional characteristics. This paper reviews the emerging roles of alginate and hyaluronic acid as sustainable biomaterials in the food and pharmaceutical industries, with emphasis on their extraction, structural properties, modification techniques, and industrial applications. Alginate, primarily obtained from brown algae, exhibits excellent gel-forming and encapsulation abilities, making it valuable in food preservation, edible coatings, controlled drug delivery, and tissue engineering. Hyaluronic acid, naturally present in animal connective tissues and microbial sources, possesses exceptional moisture retention, viscoelasticity, and biocompatibility, which support its growing utilization in wound healing, cosmetic formulations, ophthalmic preparations, and targeted therapeutic systems. Recent advances in green extraction technologies, nano-formulation, and polymer blending have further expanded the functional applications of these biomaterials. The study also highlights the economic and environmental benefits associated with the replacement of synthetic polymers by natural polysaccharides in industrial processes. Despite their enormous potential, challenges such as production cost, stability, purification efficiency, and large-scale commercialization remain major concerns requiring further scientific attention. The integration of sustainable extraction methods, biotechnology, and advanced material engineering is expected to enhance the industrial competitiveness of alginate and hyaluronic acid in the global bioeconomy. This presentation demonstrates that natural polysaccharides represent promising alternatives for the development of safer, sustainable, and multifunctional biomaterials capable of addressing current challenges in food preservation, drug delivery, and biomedical innovation

References

[1] Abd El-Hack, M. E., El-Saadony, M. T., Shafi, M. E., Alshahrani, O. A., Saghir, S. A. M., Al-Wajeeh, A. S., & Taha, A. E. (2022). Alginate-based edible coatings for food preservation and shelf-life extension: Recent advances and future prospects. Food Chemistry Advances, 1, 100056. https://doi.org/10.1016/j.focha.2022.100056⁠

[2] Ahmed, T. A., Aljaeid, B. M., & Alharbi, W. S. (2023). Natural polysaccharides in drug delivery systems: Recent advances and future perspectives. Pharmaceutics, 15(8), 2134. https://doi.org/10.3390/pharmaceutics15082134⁠

[3] Barzegari, A., et al. (2023). Alginate/hyaluronic acid-based systems as a new generation of wound dressings: A review. International Journal of Biological Macromolecules.

[4] Bhatia, S., Sharma, K., Dahiya, R., & Kumar, P. (2024). Sustainable biomaterials for healthcare applications: Current trends and future opportunities. Materials Today Sustainability, 25, 100612. https://doi.org/10.1016/j.mtsust.2024.100612⁠

[5] Darmawan, N., Wibowo, D., Prasetyo, A., & Kusuma, H. S. (2024). Encapsulation technologies for bioactive compounds in functional foods: Recent advances and applications. In Food Bioactive Ingredients and Their Applications (pp. 145–172). Wiley. https://doi.org/10.1002/9783527848133.ch7⁠

[6] El-Sayed, H., El-Sayed, A., & El-Shafey, M. (2024). Hyaluronic acid: Comprehensive review of a multifunctional biopolymer. Future Journal of Pharmaceutical Sciences, 10, 63.

[7] Khalid, A., Ahmad, N., Khan, M. I., & Hussain, S. (2024). Exploring the progress of hyaluronic acid hydrogels: Synthesis, characteristics, and wide-ranging applications. Materials, 17(10), 2439. https://doi.org/10.3390/ma17102439⁠

[8] Li, X., Zhao, Y., Wang, C., & Sun, Y. (2023). Recent developments in alginate-based biomaterials for pharmaceutical and biomedical applications. International Journal of Biological Macromolecules, 233, 123498. https://doi.org/10.1016/j.ijbiomac.2023.123498

[9] Mehta, D., Sharma, P., Kaur, G., & Kaur, H. (2024). Sustainable alginate-based packaging materials for food preservation: Current advances and future prospects. Food & Function, 15(3), 1184–1205. https://doi.org/10.1039/D3FOB00216K⁠

[10] Metha, C., Pawar, S., & Suvarna, V. (2024). Recent advancements in alginate-based films for active food packaging applications. Sustainable Food Technology, 2, 1246–1265.

[11] Morparia, K., & Suvarna, V. (2024). Alginate-based hydrogels in tissue engineering and regenerative medicine: Recent advances and future directions. Current Pharmaceutical Biotechnology, 25(4), 421–438. https://doi.org/10.2174/0113892010274034231011093347

[12] Nanda, S., Patra, B. R., Patel, R., Bakos, J., Dalai, A. K., & Kozinski, J. A. (2023). Circular bioeconomy approaches for sustainable production of biopolymers and biomaterials. Bioresource Technology Reports, 24, 101621. https://doi.org/10.1016/j.biteb.2023.101621

[13] Rahman, M. M., Shahid, M. A., Hossain, M. T., Sheikh, M. S., Rahman, M. S., Uddin, N., Rahim, A., Khan, R. A., & Hossain, I. (2024). Sources, extractions, and applications of alginate: A review. Discover Applied Sciences, 6, 443.

[14] Ren, Y., Wang, Q., Xu, W., Yang, M., Guo, W., He, S., & Liu, W. (2024). Alginate-based hydrogels mediated biomedical applications: A review. International Journal of Biological Macromolecules, 279, 135019.

[15] Sharma, A., Verma, C., Singh, P., Mukhopadhyay, S., Gupta, A., & Gupta, B. (2024). Alginate-based biomaterials for hemostatic applications: Innovations and developments. International Journal of Biological Macromolecules, 264, 130771.

[16] Simińska-Stanny, J., Podstawczyk, D., Delporte, C., Nie, L., & Shavandi, A. (2024). Hyaluronic acid role in biomaterials prevascularization. Advanced Healthcare Materials, 13(2402045), 1–25. https://doi.org/10.1002/adhm.202402045

[17] United Nations Environment Programme. (2024). Global waste management outlook 2024: Pathways toward sustainable materials and circular economy. United Nations Environment Programme.

[18] Wang, H., Zhou, Y., Chen, S., & Xu, J. (2022). Hyaluronic acid-based biomaterials for tissue engineering and regenerative medicine. Bioactive Materials, 14, 98–117. https://doi.org/10.1016/j.bioactmat.2021.11.012⁠

[19] Wawszczak, A., Kocki, J., & Kołodyńska, D. (2024). Alginate as a sustainable and biodegradable material for medical and environmental applications—The case studies. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 112(e35475). https://doi.org/10.1002/jbm.b.35475⁠

[20] World Health Organization. (2024). Global strategy on sustainable health technologies and biomedical innovation. World Health Organization.

[21] Yazdanpanah, S., Romano, S., Galderisi, U., Sepe, F., Peluso, G., Conte, R., & Calarco, A. (2026). Biotechnologically derived materials as drug delivery systems for tissue regeneration. Frontiers in Bioscience (Elite Edition), 18(2), 44545. https://doi.org/10.31083/FBE44545.

[22] Ye, H., Zhang, R., Zhang, C., Xia, Y., & Jin, L. (2024). Advances in hyaluronic acid: Bioactivity, complexed biomaterials and biological application: A review. Alexandria Journal of Medicine/Surgery (online ahead of print). ⁠

[23] Zhao, Q., Liu, X., Wang, J., Li, Y., & Chen, H. (2024). Alginate encapsulation technologies for bioactive delivery in food and pharmaceutical systems. Food Hydrocolloids, 149, 109451. https://doi.org/10.1016/j.foodhyd.2024.109451⁠

[24] ⁠Zhang, Y., Li, X., Chen, H., Wang, J., & Liu, Z. (2023). Sustainable extraction and purification strategies for hyaluronic acid production: A review. Carbohydrate Polymers, 315, 120982. https://doi.org/10.1016/j.carbpol.2023.120982⁠

How to cite this paper

Itodo, I. N., ABEL, E. D., Esievo L. O. "Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries" Iconic Research And Engineering Journals Volume 10 Issue 1 2026 Page 1585-1596 https://doi.org/10.64388/IREV10I1-1719732
Itodo, I. N., ABEL, E. D., Esievo L. O. "Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries" Iconic Research And Engineering Journals, vol. 10, no. 1, Jul. 2026, doi: https://doi.org/10.64388/IREV10I1-1719732
Itodo, I. N., ABEL, E. D., Esievo L. O. (2026). Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries. Iconic Research And Engineering Journals, 10(1). doi: https://doi.org/10.64388/IREV10I1-1719732
Itodo, I. N., ABEL, E. D., Esievo L. O. "Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries" Iconic Research And Engineering Journals, vol. 10, no. 1, Jul. 2026. Crossref, https://doi.org/10.64388/IREV10I1-1719732
@article{1719732,
      author = {Itodo, I. N., ABEL, E. D., Esievo L. O.},
      title = {Natural Polysaccharides as Sustainable Biomaterials: Emerging Applications of Alginate and Hyaluronic Acid in Food and Pharmaceutical Industries},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {10},
      number = {1},
      pages = {1585-1596},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1719732.pdf},
      abstract = {The increasing demand for sustainable, biocompatible, and environmentally friendly materials has intensified research interest in naturally derived polysaccharides for industrial and biomedical applications. Among these biopolymers, alginate and hyaluronic acid have gained significant attention due to their remarkable physicochemical properties, biodegradability, non-toxicity, and versatile functional characteristics. This paper reviews the emerging roles of alginate and hyaluronic acid as sustainable biomaterials in the food and pharmaceutical industries, with emphasis on their extraction, structural properties, modification techniques, and industrial applications. Alginate, primarily obtained from brown algae, exhibits excellent gel-forming and encapsulation abilities, making it valuable in food preservation, edible coatings, controlled drug delivery, and tissue engineering. Hyaluronic acid, naturally present in animal connective tissues and microbial sources, possesses exceptional moisture retention, viscoelasticity, and biocompatibility, which support its growing utilization in wound healing, cosmetic formulations, ophthalmic preparations, and targeted therapeutic systems. Recent advances in green extraction technologies, nano-formulation, and polymer blending have further expanded the functional applications of these biomaterials. The study also highlights the economic and environmental benefits associated with the replacement of synthetic polymers by natural polysaccharides in industrial processes. Despite their enormous potential, challenges such as production cost, stability, purification efficiency, and large-scale commercialization remain major concerns requiring further scientific attention. The integration of sustainable extraction methods, biotechnology, and advanced material engineering is expected to enhance the industrial competitiveness of alginate and hyaluronic acid in the global bioeconomy. This presentation demonstrates that natural polysaccharides represent promising alternatives for the development of safer, sustainable, and multifunctional biomaterials capable of addressing current challenges in food preservation, drug delivery, and biomedical innovation},
      month = {July},
      doi = {https://doi.org/10.64388/IREV10I1-1719732}
  }