Zinc (II) Schiff Base Metal Complex: Synthesis, Characterization and Enhanced Antibacterial Activity

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@article{1719999,
      author = {Pawan R. Jagnit, Yogesh I. Biradar, Satish V. Jadhav, S. R. Kelode},
      title = {Zinc (II) Schiff Base Metal Complex: Synthesis, Characterization and Enhanced Antibacterial Activity},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {10},
      number = {1},
      pages = {3130-3141},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1719999.pdf},
      abstract = {The present study reports the synthesis and characterization of a novel Zn(II) Schiff base metal complex derived from the ligand 4,5-dimethyl-2-[(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]phenol. The Schiff base ligand and its Zn(II) complex were successfully synthesized and characterized using various physicochemical and spectroscopic techniques including UV–Visible spectroscopy, FTIR, X-ray diffraction (XRD), and NMR analysis. Spectral investigations confirmed the successful coordination of the ligand with Zn(II) ions through the azomethine nitrogen and phenolic oxygen donor atoms, leading to the formation of a stable chelated complex. FTIR spectra revealed characteristic shifts in the azomethine (C=N) and phenolic (O–H) bands upon complexation, while UV–Visible studies supported the metal–ligand interaction and octahedral structure. XRD analysis indicated the crystalline nature of the synthesized complex, and NMR studies further confirmed the proposed structure of the Schiff base ligand and its coordination environment. The antibacterial activity of the synthesized compounds was evaluated against Anthrax bacterium using the agar well diffusion method. The Zn(II) complex exhibited enhanced antibacterial activity compared to the free Schiff base ligand, showing larger zones of inhibition against Bacillus anthracis. The improved biological activity of the metal complex may be attributed to chelation, which increases lipophilicity and facilitates better penetration through the bacterial cell membrane, thereby enhancing interaction with intracellular targets. The findings suggest that the synthesized Zn(II) Schiff base complex possesses promising antibacterial potential and may serve as an effective candidate for future antimicrobial applications.},
      month = {July},
      doi = {https://doi.org/10.64388/IREV10I1-1719999}
  }