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To Formulate and Evaluate Herbal Paint for Topical Infections
Subject area: Biological & Medical Sciences · Area of research: Pharmaceutical
Abstract
Topical microbial infections, including bacterial and fungal skin disorders, represent a significant clinical concern due to their high prevalence and increasing resistance to conventional antimicrobial agents. Synthetic topical therapies, although effective, are often associated with adverse effects such as irritation, hypersensitivity, and development of antimicrobial resistance. This has led to growing interest in phytopharmaceutical approaches utilizing bioactive plant constituents. The present study focuses on the formulation and evaluation of a herbal paint for topical infections incorporating extracts of Zingiber officinale (Ginger), Azadirachta indica (Neem), Curcuma longa (Turmeric), and Aloe barbadensis (Aloe vera). These medicinal plants are rich in diverse phytoconstituents such as gingerols and shogaols (ginger), azadirachtin and nimbidin (neem), curcuminoids (turmeric), and polysaccharides along with anthraquinones (aloe vera). These compounds exhibit potent antimicrobial, anti-inflammatory, antioxidant, and wound healing activities through mechanisms such as disruption of microbial cell membranes, inhibition of pro-inflammatory mediators, and scavenging of reactive oxygen species (ROS). The herbal paint formulation was developed using suitable solvents and excipients to achieve optimal film-forming ability, spreadability, and stability. The prepared formulations were subjected to comprehensive evaluation including organoleptic properties, pH determination, viscosity, drying time, and spreadability. Furthermore, antimicrobial activity was assessed using standard microbiological techniques against common pathogenic strains, and skin irritation studies were conducted to ensure dermal safety. The optimized formulation demonstrated desirable physicochemical characteristics, rapid drying behavior, uniform film formation, and significant antimicrobial activity, indicating a synergistic effect of combined phytoconstituents. No signs of irritation or adverse reactions were observed during safety evaluation. In conclusion, the formulated herbal paint represents a promising phytotherapeutic topical delivery system with enhanced efficacy and safety profile for the management of minor skin infections. The study highlights the potential of plant-derived bioactive compounds as effective alternatives to synthetic antimicrobial agents. Further investigations involving clinical studies and stability profiling are recommended to validate long-term efficacy and commercialization potential.
How to cite this paper
@article{1722156,
author = {Ankit D. Nagpure, Rutik Palaskar, Rahul Chaudhari, Ajay Dongarwar},
title = {To Formulate and Evaluate Herbal Paint for Topical Infections},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {10},
number = {2},
pages = {582-591},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1722156.pdf},
abstract = {Topical microbial infections, including bacterial and fungal skin disorders, represent a significant clinical concern due to their high prevalence and increasing resistance to conventional antimicrobial agents. Synthetic topical therapies, although effective, are often associated with adverse effects such as irritation, hypersensitivity, and development of antimicrobial resistance. This has led to growing interest in phytopharmaceutical approaches utilizing bioactive plant constituents. The present study focuses on the formulation and evaluation of a herbal paint for topical infections incorporating extracts of Zingiber officinale (Ginger), Azadirachta indica (Neem), Curcuma longa (Turmeric), and Aloe barbadensis (Aloe vera). These medicinal plants are rich in diverse phytoconstituents such as gingerols and shogaols (ginger), azadirachtin and nimbidin (neem), curcuminoids (turmeric), and polysaccharides along with anthraquinones (aloe vera). These compounds exhibit potent antimicrobial, anti-inflammatory, antioxidant, and wound healing activities through mechanisms such as disruption of microbial cell membranes, inhibition of pro-inflammatory mediators, and scavenging of reactive oxygen species (ROS). The herbal paint formulation was developed using suitable solvents and excipients to achieve optimal film-forming ability, spreadability, and stability. The prepared formulations were subjected to comprehensive evaluation including organoleptic properties, pH determination, viscosity, drying time, and spreadability. Furthermore, antimicrobial activity was assessed using standard microbiological techniques against common pathogenic strains, and skin irritation studies were conducted to ensure dermal safety. The optimized formulation demonstrated desirable physicochemical characteristics, rapid drying behavior, uniform film formation, and significant antimicrobial activity, indicating a synergistic effect of combined phytoconstituents. No signs of irritation or adverse reactions were observed during safety evaluation. In conclusion, the formulated herbal paint represents a promising phytotherapeutic topical delivery system with enhanced efficacy and safety profile for the management of minor skin infections. The study highlights the potential of plant-derived bioactive compounds as effective alternatives to synthetic antimicrobial agents. Further investigations involving clinical studies and stability profiling are recommended to validate long-term efficacy and commercialization potential.},
month = {August},
}