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Comparison Of Macular Thickness Among Myopes and Emmetropes in Port Harcourt, Rivers State, Using Spectral Domain Optical Coherence Tomography
Subject area: Biological & Medical Sciences · Area of research: Vision Science
DOI: https://doi.org/10.64388/IREV10I2-1722614
Abstract
Myopia is a leading cause of visual impairment worldwide and is associated with structural alterations of the retina particularly the macula. Spectral Domain Optical Coherence Tomography (SD-OCT) provides accurate and reproducible measurements of macular thickness, but data among Nigerian adults remain limited. This study comparted macular thickness among myopic and emmetropic adults in Port Harcourt, Rivers State, using SD-OCT. A comparative cross-sectional study was conducted among adults aged 18-40 years attending an eye specialist hospital. Participants were classified into myopic and emmetropic groups according to spherical equivalent refractive error. Central, inner, outer, and average ocular thicknesses were measured using a Topcon SD-OCT system based on the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol. Data were analyzed using SPSS version 23, with statistical significance set at p<0.05. Myopic eyes had significantly lower macular thickness than emmetropic eyes. Central macular thickness was 188.11 ± 24.83 µm in myopes versus 200.30 ± 16.81 µm in emmetropes (p = 0.046). Inner macular thickness was 281.75 ± 14.44 µm versus 295.92 ± 44.76 µm (p = 0.039), outer macular thickness was 257.80 ± 13.90 µm versus 280.07 ± 9.30 µm (p < 0.001), while average macular thickness was 266.99 ± 12.78 µm versus 291.66 ± 19.02 µm (p < 0.001). Myopic eyes demonstrated significantly reduced central, inner, outer, and average macular thickness compared with emmetropic eyes. These findings emphasize the importance of considering refractive status during SD-OCT interpretation and support further studies involving larger Nigerian populations.
Keywords
Myopia; Emmetropia; Macular Thickness; Optical Coherence Tomography; SD-OCT.
References
[1] Baird PN, Saw SM, Lanca C, Guggenheim JA, Smith EL, Zhou X, et al. Myopia. Nature Reviews Disease Primers. 2020;6(1):99. doi:10.1038/s41572-020-00231-4.
[2] Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, et al. Global causes of blindness and distance vision impairment 1990–2020: A systematic review and meta-analysis. The Lancet Global Health, 2017;5(12):e1221–e1234. doi.10.1016/S2214-109X(17)30393-5.
[3] Fang Y, Yokoi T, Ohno-Matsui K. Structural changes in the macula of highly myopic eyes. Ophthalmology. 2025;132(4): 512–520. doi.10.1016/j.ophtha.2024.10.018.
[4] Ikuno Y. Overview of the complications of high myopia. Retina, 2017;37(12), 2347–2351. https://doi.org/10.1097/IAE.0000000000001481.
[5] Liu X, Shen M, Yuan Y, Huang S, Zhu D, Ma Q, Lu F. Macular thickness profiles of high myopia using spectral-domain optical coherence tomography. Retina, 2015;35(2), 392–398. https://doi.org/10.1097/IAE.0000000000000322.
[6] Ghassibe E, Sacconi R, Corbelli E, Rabiolo A, Mercuri S, Bandello F. Visual acuity in pathological myopia. Translational Vision Science & Technology. 2019;8(2):26. doi.10.1167/tvst.8.2.26.
[7] Adhi M, Duker JS. Optical coherence tomography—Current and future applications. Current Opinion in Ophthalmology. 2013;24(3):213–221. doi: 10.1097/MCO.0b013e328361bae5.
[8] Hashemi H, Heydarian S, Hashemi A, Khabazkhoob M. Macular thickness and volume by spectral-domain optical coherence tomography and their related factors in the elderly population. J Curr Ophthalmol. 2024;35(4):362-368. doi:10.4103/joco.joco_153_23.
[9] Hwang YH, Kim YY. Macular thickness and volume of myopic eyes measured using spectral-domain optical coherence tomography. Clinical and Experimental Optometry 2012;95(5), 492–498. https://doi.org/10.1111/j.1444-0938.2012.00749.x.
[10] Patel PJ, Foster PJ, Grossi CM, Keane PA, Ko F, Lotery A, UK Biobank Eyes and Vision Consortium. Spectral-domain optical coherence tomography imaging in 67,321 adults: Associations with macular thickness in the UK Biobank study. Ophthalmology. 2016;123(4), 829–840. https://doi.org/10.1016/j.ophtha.2015.11.009.
[11] Read SA, Alonso-Caneiro D, Vincent SJ, Collins MJ. Macular retinal layer thickness in myopia: A meta-analysis. Clinical and Experimental Optometry. 2019;102(3), 247–258. https://doi.org/10.1111/cxo.12894.
[12] Eze UA, Obasuyi OC, Salihu DV, Bature M, Yeye-Agba OO, Kanmodi KK. Prevalence and causes of blindness and visual impairment among Nigerians: A systematic review. Clinical Ophthalmology. 2024; 18:289-301. doi.102147/OPTH.S440744.
[13] Ezegwui IR, Oguego NC, Okoye OI, Maduka-Okafor FC, Udeh N, Aghaji AE, et al. Prevalence of refractive errors and visual impairment in school children in Enugu, South-East Nigeria. Nigerian Journal of Clinical Practice. 2021;24(3):380-386. Doi.10.410.4103/njcp.njcp_521_19.
[14] Oderinlo O, Bogunjoki T, Hassan AO, Idris O, Dalley A, Oshunkoya L, et al. Normal central foveal thickness in a thousand eyes of healthy patients in sub-Saharan Africa using Fourier domain optical coherence tomography. Niger J Clin Pract. 2023;26(3):331-335. doi.10.4103/njcp.njcp_318_22.
[15] Kim JH., Lee SH, Park SY. Macular thickness profile in myopic eyes: An OCT-based study. BMC Ophthalmol. 2023; 23:145.
[16] Lee SS, Lingham G, Guggenheim JA. Axial length and macular thickness relationship in myopia. Investigative Ophthalmol & Vis Sci. 2024;65(2):8.
[17] Song AP, Wu XY, Wang JR, Liu W, Sun Y, Yu T. Measurement of retinal thickness in macular region of high myopic eyes using spectral domain OCT. Int J Ophthalmol. 2014;7(1):122-127.
[18] Xiong S, He X, Zhang B, Wang J, Zhu Z, Zou H, et al. Macular measurements using spectral-domain optical coherence tomography in Chinese myopic children. Exp Ther Med. 2018;16(6):5357–5362. doi:10.3892/etm.2018.6854.
How to cite this paper
@article{1722614,
author = {Ozurumba Oluchi Adanna, Azuamah Y. C., Daniel-Nwosu E. I., Megwas A. U.; Ikoro N. C., Sam-Duru P. A.; Nwanesindu U. E.; Eronini Y. R.},
title = {Comparison Of Macular Thickness Among Myopes and Emmetropes in Port Harcourt, Rivers State, Using Spectral Domain Optical Coherence Tomography},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {10},
number = {2},
pages = {3257-3264},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1722614.pdf},
abstract = {Myopia is a leading cause of visual impairment worldwide and is associated with structural alterations of the retina particularly the macula. Spectral Domain Optical Coherence Tomography (SD-OCT) provides accurate and reproducible measurements of macular thickness, but data among Nigerian adults remain limited. This study comparted macular thickness among myopic and emmetropic adults in Port Harcourt, Rivers State, using SD-OCT. A comparative cross-sectional study was conducted among adults aged 18-40 years attending an eye specialist hospital. Participants were classified into myopic and emmetropic groups according to spherical equivalent refractive error. Central, inner, outer, and average ocular thicknesses were measured using a Topcon SD-OCT system based on the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol. Data were analyzed using SPSS version 23, with statistical significance set at p<0.05. Myopic eyes had significantly lower macular thickness than emmetropic eyes. Central macular thickness was 188.11 ± 24.83 µm in myopes versus 200.30 ± 16.81 µm in emmetropes (p = 0.046). Inner macular thickness was 281.75 ± 14.44 µm versus 295.92 ± 44.76 µm (p = 0.039), outer macular thickness was 257.80 ± 13.90 µm versus 280.07 ± 9.30 µm (p < 0.001), while average macular thickness was 266.99 ± 12.78 µm versus 291.66 ± 19.02 µm (p < 0.001). Myopic eyes demonstrated significantly reduced central, inner, outer, and average macular thickness compared with emmetropic eyes. These findings emphasize the importance of considering refractive status during SD-OCT interpretation and support further studies involving larger Nigerian populations.},
keywords = {Myopia; Emmetropia; Macular Thickness; Optical Coherence Tomography; SD-OCT.},
month = {August},
doi = {https://doi.org/10.64388/IREV10I2-1722614}
}