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Frequency of Thrombocytopenia Among Adults with Malaria in Merowe City, Sudan, November 2021 to September 2022
Subject area: Biological & Medical Sciences · Area of research: Internal medicine (Heamatology)
DOI: https://doi.org/10.64388/IREV10I2-1722623
Abstract
Malaria is associated with haematological abnormalities, including thrombocytopenia. This study determined the frequency of thrombocytopenia among adults with malaria in Merowe City, Sudan, and compared its occurrence between Plasmodium falciparum and Plasmodium vivax infections. We conducted a retrospective cross-sectional study at Al-Gawda and Al-Ehsan Medical Centres in Merowe City, Northern State, Sudan, from November 2021 to September 2022. De-identified records of adults aged >18 years with confirmed malaria were reviewed. Complete blood count, malaria blood-film, and immunochromatographic test results were extracted. Thrombocytopenia was defined as a platelet count <150,000/mm³. Descriptive analyses were performed using SPSS version 16.0. Of 149 adults with malaria, 100 (67.1%) had P. falciparum and 49 (32.9%) had P. vivax. Thrombocytopenia was identified in 13 patients (8.7%). It occurred in 8/100 (8.0%) patients with P. falciparum and 5/49 (10.2%) patients with P. vivax. Minor bleeding was reported in one patient with P. vivax; no bleeding was reported among patients with P. falciparum. Thrombocytopenia occurred in approximately one in eleven adults with malaria and was slightly more frequent among patients with P. vivax than among those with P. falciparum. In patients presenting with acute febrile illness, thrombocytopenia may support clinical suspicion of malaria, although it should not be considered a stand-alone diagnostic test. Larger prospective studies are warranted.
Keywords
thrombocytopenia; malaria; Plasmodium falciparum; Plasmodium vivax; Sudan
References
[1] WHO World Malaria Report 2020, World Malaria Report 2020.
[2] African Leaders Malaria Alliance. Sudan ALMA quarterly report: quarter three, 2021 (scorecard for accountability and action) [Internet]. 2021 [cited 2026 Mar 30]. Available from: https://alma2030.org/wp- content/uploads/2023/01/sudan-quarterly- report-2021-q3-en.pdf
[3] World Health Organization. World malaria report 2021: regional briefing kit (regional data and trends) [Internet]. Geneva: World Health Organization; 2021 [cited 2026 Mar 30]. Available from: https://cdn.who.int/media/docs/default- source/malaria/world-malaria-reports/world- malaria-report-2021-regional-briefing-kit- eng.pdf
[4] Menkin Smith L, Winders WT. Plasmodium vivax malaria. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2026 Mar 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538 333/
[5] Rich, S. M.; Leendertz, F. H.; Xu, G.; Lebreton, M.; Djoko, C. F.; Aminake, M. N.; Takang, E. E.; Diffo, J. L. D.; Pike, B. L.; Rosenthal, B. M.; Formenty, P.; Boesch, C.; Ayala, F. J.; Wolfe, N. D. (2009). "The origin of malignant malaria". Proceedings of the National Academy of Sciences. 106 (35): 14902–14907. Bibcode:2009PNAS..10614902R. 2720412. PMID 19666593.
[6] White N. J., Plasmodium knowlesi: The Fifth Human Malaria Parasite, Clinical Infectious Diseases, Volume 46, Issue 2, 15 January 2008, Pages 172 –173, https://
[7] Fielding, L. P., Stewart-Brown, S., & Blesovsky, L. (1979). Large -Bowel Obstruction Caused By Cancer: A Prospective Study. The British Medical Journal, 2(6189), 515–517. http://www.jstor.org/stable/25436717
[8] Elkhalifa AME, Abdul-Ghani R, Tamomh AG, Eltaher NE, Ali NY, Ali MM, et al. Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study. BMC Infect Dis. 2021;21(1):507.
[9] Ebraheem A A, Abdelrahim Y H, Gibreel A A, MohamedAhmed A A E, Nour B Y, Abdalla A O, Ahmed H M and Elhadi A, 2025. "Thrombocytopenia Due to Plasmodium falciparum Infection and Its Association with Clinical Symptoms, Wad Medani Teaching Hospital, Sudan," European Journal of Medical and Health Sciences, European Open Science, vol. 7(1), pages 22-28, January.
[10] Khan SJ, Abbass Y, Marwat MA. Thrombocytopenia as an indicator of malaria in adult population. Malar Res Treat. 2012;2012:405981.
[11] Kumar M, Kumar A, Panwar P, Kant R. Correlation of presence and severity of thrombocytopenia with types and severity of malaria: a study from tertiary care center of North India. J Family Med Prim Care. 2022;11(7):3929–3933.
[12] Bansal Y, Maurya V, Aggarwal N, Tak V, Nag VL, Purohit A, et al. Thrombocytopenia in malaria patients from an arid region of Western Rajasthan (India). Trop Parasitol. 2020;10(2):95–101.
[13] Awoke N, Arota A. Profiles of hematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia. Infect Drug Resist. 2019;12:521– 527.
[14] Kochar DK, Das A, Kochar A, Middha S, Acharya J, Tanwar GS, et al. Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India). Platelets. 2010;21(8):623–627.
[15] Muley A, Lakhani J, Bhirud S, Patel A. Thrombocytopenia in Plasmodium vivax malaria: how significant? J Trop Med. 2014;2014:567469.
[16] Naing C, Whittaker MA. Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria: a systematic review and meta-analysis. Infect Dis Poverty. 2018;7(1):10.
[17] Saravu K, Docherla M, Vasudev A, Shastry BA. Thrombocytopenia in vivax and falciparum malaria: an observational study of 131 patients in Karnataka, India. Ann Trop Med Parasitol. 2011;105(8):593–598.
[18] Lacerda MV, Mourão MP, Coelho HC, Santos JB. Thrombocytopenia in malaria: who cares? Mem Inst Oswaldo Cruz. 2011;106 Suppl 1:52–63. 0276201100090000
How to cite this paper
@article{1722623,
author = {Mohammed M. M. Makkawi, Wafa M. M. Alamin},
title = {Frequency of Thrombocytopenia Among Adults with Malaria in Merowe City, Sudan, November 2021 to September 2022},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {10},
number = {2},
pages = {3265-3269},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1722623.pdf},
abstract = {Malaria is associated with haematological abnormalities, including thrombocytopenia. This study determined the frequency of thrombocytopenia among adults with malaria in Merowe City, Sudan, and compared its occurrence between Plasmodium falciparum and Plasmodium vivax infections. We conducted a retrospective cross-sectional study at Al-Gawda and Al-Ehsan Medical Centres in Merowe City, Northern State, Sudan, from November 2021 to September 2022. De-identified records of adults aged >18 years with confirmed malaria were reviewed. Complete blood count, malaria blood-film, and immunochromatographic test results were extracted. Thrombocytopenia was defined as a platelet count <150,000/mm³. Descriptive analyses were performed using SPSS version 16.0. Of 149 adults with malaria, 100 (67.1%) had P. falciparum and 49 (32.9%) had P. vivax. Thrombocytopenia was identified in 13 patients (8.7%). It occurred in 8/100 (8.0%) patients with P. falciparum and 5/49 (10.2%) patients with P. vivax. Minor bleeding was reported in one patient with P. vivax; no bleeding was reported among patients with P. falciparum. Thrombocytopenia occurred in approximately one in eleven adults with malaria and was slightly more frequent among patients with P. vivax than among those with P. falciparum. In patients presenting with acute febrile illness, thrombocytopenia may support clinical suspicion of malaria, although it should not be considered a stand-alone diagnostic test. Larger prospective studies are warranted.},
keywords = {thrombocytopenia; malaria; Plasmodium falciparum; Plasmodium vivax; Sudan},
month = {August},
doi = {https://doi.org/10.64388/IREV10I2-1722623}
}