Synthesis and Biological Evaluation of Novel Schiff Base Derivatives

@article{1722986,
      author = {Dr. K. S. Lamani},
      title = {Synthesis and Biological Evaluation of Novel Schiff Base Derivatives},
      journal = {Iconic Research And Engineering Journals},
      year = {2019},
      volume = {2},
      number = {9},
      pages = {523-531},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1722986.pdf},
      abstract = {In the field of medicinal chemistry, Schiff base derivatives are essential class of organic compounds because of its interesting structural flexibility, easy of synthesis and a variety of biological activities due to presence of imine or its derivatives which consists of characteristic C=N group in their molecules due to which such compounds possess strong electro donating power, hydrogen bond acceptability (in its neutral state) and can undergo metal coordination or interact with specific active site of the biological targets; these molecules attracted much attention from researchers working on medicinal field due to well-known antimicrobial, anticancer, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory activities attributed from them and these compounds are found to be effective scaffolds for development of new drugs; however the rise in multidrug resistance development, some drawbacks of the available drugs, undesirable side effects and lack of efficacy may be due to decreased activity have been established, thus it becomes indispensable task to search new molecules with higher potential and better therapeutic properties and also due to constant requirement of new drug molecules, there has been an urge to identify novel pharmacologically active molecules with advanced benefits. Therefore, in this article a conceptual research is discussed concerning design, synthesis, characterization and biological assessment of Schiff base derivatives, based on rationally planned modification of the aldehyde and primary amine which may lead to diverse structures of imine containing molecules for designing novel chemical entities with possible pharmaceutical relevance; a synthetic strategy was designed on basis of condensation reactions among preselected aldehyde and amines followed by functional modification of resultant compound so as to achieve the desired property modification. Spectroscopic method such as FTIR, H, C NMR and Mass Spectroscopy are conceptually included to characterize the compounds developed which are formed on the modification and thus will confirm presence of the functional group, structural features of the molecules and their molecular mass and weight. Computational molecular docking and ADMET study are then proposed to study behavior with biologically relevant molecules and thus predicts how the molecules behave when dosed as drug candidates through prediction of molecular parameters and properties. Some of the biological activity screening like antibacterial, antifungal, anticancer, antioxidant, anti-inflammatory studies are theoretically planned which would help us to estimate some relation between structure activity. The anticipated outcome of this study would be the identification of compounds of the present class of Schiff base derivatives to serve as lead candidates for new drugs and exploration of the structure activity relations and designs.},
      keywords = {Schiff bases, Imine compounds, Condensation reaction, Medicinal chemistry, antimicrobial activity, Anticancer activity, Structure–activity relationship, Organic synthesis},
      month = {March},
  }