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Antidairreal Activity of Methanolic Stem Bark Extracts of Anogeissus Leiocarpus in Albino Rats
Subject area: Physical Sciences and Environment · Area of research: Medicinal Chemistry
DOI: 10.64388/IREV10I3-1723065
Abstract
Diarrhoea remains a major global health concern, especially in developing countries where herbal remedies are commonly used for treatment. This study investigated the antidiarrhoeal activity of the methanol stem bark extract of Anogeissus leiocarpus in Wistar albino rats. The antidiarrhoeal effect was evaluated using three models: castor oil-induced diarrhoea, charcoal meal gastrointestinal transit, and castor oil-induced enteropooling. The extract was administered orally at doses of 200, 400, and 800 mg/kg. Loperamide (5 mg/kg) and atropine (3 mg/kg) served as standard drugs, while normal saline served as the negative control. In the castor oil-induced diarrhoea model, the extract produced a significant (p < 0.05) and dose-dependent protection of 24.5%, 52.8%, and 59.4% at 200, 400, and 800 mg/kg respectively. The normal saline group had 0% protection, while loperamide produced 90.4% protection. In the charcoal meal test, the extract caused a significant (p < 0.05) and dose-dependent reduction in intestinal transit with percentage inhibitions of 19.3%, 35.7%, and 50.2% at 200, 400, and 800 mg/kg respectively, compared to 80.6% inhibition by atropine. In the enteropooling model, the extract also produced a significant (p < 0.05) and dose-dependent inhibition of intestinal fluid accumulation of 70.0%, 78.0%, and 85.7% at 200, 400, and 800 mg/kg respectively, compared to 90.6% inhibition by loperamide. The normal saline group had 0% inhibition. These findings suggest that the methanol stem bark extract of Anogeissus leiocarpus possesses potent antidiarrhoeal activity via antimotility and antisecretory mechanisms. The results provide scientific support for the traditional use of Anogeissus leiocarpus in the management of diarrhoea and related gastrointestinal disorders.
Keywords
antidiarrhoeal activity; Anogeissus leiocarpus; castor oil-induced diarrhoea; enteropooling; gastrointestinal transit
How to cite this paper
@article{1723065,
author = {Dr. Samuel Ibrahim Dawa, Dr. James Yakubu, Dr. Esther Ishaya Ville; Sheriff Adam, Saeed Muhammad Dalla; Albashir Umar Rufai, Salihu Gwale Liman; Babagana Ali},
title = {Antidairreal Activity of Methanolic Stem Bark Extracts of Anogeissus Leiocarpus in Albino Rats},
journal = {Iconic Research And Engineering Journals},
year = {2026},
volume = {10},
number = {3},
pages = {4109-4116},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1723065.pdf},
abstract = {Diarrhoea remains a major global health concern, especially in developing countries where herbal remedies are commonly used for treatment. This study investigated the antidiarrhoeal activity of the methanol stem bark extract of Anogeissus leiocarpus in Wistar albino rats. The antidiarrhoeal effect was evaluated using three models: castor oil-induced diarrhoea, charcoal meal gastrointestinal transit, and castor oil-induced enteropooling. The extract was administered orally at doses of 200, 400, and 800 mg/kg. Loperamide (5 mg/kg) and atropine (3 mg/kg) served as standard drugs, while normal saline served as the negative control. In the castor oil-induced diarrhoea model, the extract produced a significant (p < 0.05) and dose-dependent protection of 24.5%, 52.8%, and 59.4% at 200, 400, and 800 mg/kg respectively. The normal saline group had 0% protection, while loperamide produced 90.4% protection. In the charcoal meal test, the extract caused a significant (p < 0.05) and dose-dependent reduction in intestinal transit with percentage inhibitions of 19.3%, 35.7%, and 50.2% at 200, 400, and 800 mg/kg respectively, compared to 80.6% inhibition by atropine. In the enteropooling model, the extract also produced a significant (p < 0.05) and dose-dependent inhibition of intestinal fluid accumulation of 70.0%, 78.0%, and 85.7% at 200, 400, and 800 mg/kg respectively, compared to 90.6% inhibition by loperamide. The normal saline group had 0% inhibition. These findings suggest that the methanol stem bark extract of Anogeissus leiocarpus possesses potent antidiarrhoeal activity via antimotility and antisecretory mechanisms. The results provide scientific support for the traditional use of Anogeissus leiocarpus in the management of diarrhoea and related gastrointestinal disorders.},
keywords = {antidiarrhoeal activity; Anogeissus leiocarpus; castor oil-induced diarrhoea; enteropooling; gastrointestinal transit},
month = {September},
doi = {https://doi.org/10.64388/IREV10I3-1723065}
}