Formulation, Development and Evaluation of Pulsatile Drug Delivery of Rizatriptan for Chronotherapy of Migraine

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@article{1723252,
      author = {Ekta Jha, Dr. Pradeep Chauhan, Dr. Sandeep Jain, Dr. Bharat K. Tyagi},
      title = {Formulation, Development and Evaluation of Pulsatile Drug Delivery of Rizatriptan for Chronotherapy of Migraine},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {10},
      number = {3},
      pages = {2177-2187},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1723252.pdf},
      abstract = {Migraine is a common neurological disorder characterized by recurrent attacks of moderate-to-severe headache, often accompanied by nausea, vomiting, photophobia and phonophobia. The onset of migraine attacks demonstrates temporal variability, with several clinical studies reporting a predominance of attacks during the early morning hours. Conventional immediate-release rizatriptan provides rapid symptomatic treatment but does not address the temporal pattern of migraine occurrence. Pulsatile drug delivery systems are designed to provide a predetermined lag time followed by rapid drug release and therefore offer a promising approach for chronotherapy. The present research proposes the formulation and evaluation of a pulsatile oral drug delivery system containing rizatriptan, designed to provide a controlled lag period followed by rapid drug release corresponding to the anticipated period of migraine attack. Rizatriptan was selected because of its established antimigraine activity and relatively short elimination half-life, making temporal control of drug availability a potentially useful formulation strategy. The proposed formulation is expected to remain substantially intact during the predetermined lag period and subsequently produce a rapid pulse of rizatriptan. Such a system could potentially synchronize drug availability with the circadian pattern of migraine and reduce the delay between drug administration and anticipated attack onset. Further in-vivo and clinical studies would be necessary to establish its therapeutic superiority over conventional rizatriptan formulations.},
      keywords = {Rizatriptan, pulsatile drug delivery, chronotherapy, migraine, circadian rhythm, lag time, controlled release, chrono pharmaceutics.},
      month = {September},
  }