Abstract
Parkinson’s disease is a neurodegenerative disorder arising in elderly people above the age of 60. More than 10 million people worldwide are living with Parkinson’s disease. The loss of dopaminergic neurons which produce and release dopamine leads to PD. These neurons play a crucial role in motor control and coordination. Current treatments include dopamine replacement therapy(DRT) which do not possess the potential in managing extreme motor symptoms in patients who have advanced PD. However, in recent years stem cell-based therapies have been studied due to their potential in treating PD. Cell replacement therapy(CRT) has emerged as a promising research area in which dopaminergic neurons are replaced with healthy neurons that seek to achieve sustained motor function improvements. Researchers have studied different types of stem cells, including embryonic stem cells (ESCs),neural stem cells (NSCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (IPSCs).However, cell-based therapies still face various challenges such as tumorigenicity and ethical concerns for stem cells such as ESCs.However these challenges could be overcomed . For example, integrating nanotechnology and sttem cell based therapy could improve safety and efficasy of CRT. This review provides a comprehensive overview on the current treatments for Parkinson’s disease using stem cells , the challenges and the future directions for this path of research such as nano-stem treatments.
Citations
IRE Journals:
Darshana Padmakumar "Parkinson's Disease and Stem Cell-Based Therapies: Current Research and Future Directions" Iconic Research And Engineering Journals Volume 9 Issue 8 2026 Page 495-500 https://doi.org/10.64388/IREV9I8-1714220
IEEE:
Darshana Padmakumar
"Parkinson's Disease and Stem Cell-Based Therapies: Current Research and Future Directions" Iconic Research And Engineering Journals, 9(8) https://doi.org/10.64388/IREV9I8-1714220
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