Effects of Zinc on Fertility Parameters in Tramadol-Treated Male Wistar Rats

• Author(s): Ufuoma Joy Ejite ; Prof. Ologhaguo M Adienbo
• Paper ID: 1708821
• Page: 2005-2008
• Published Date: 29-05-2025
• Published In: Iconic Research And Engineering Journals
• Publisher: IRE Journals
• e-ISSN: 2456-8880
• Volume/Issue: Volume 8 Issue 11 May-2025

Abstract

Tramadol dependence is a growing public health concern with established deleterious effects on reproductive health, particularly in males. This study investigated the potential ameliorative effects of zinc on fertility parameters in male Wistar rats treated with tramadol. Twenty-five male Wistar rats were divided into five groups: control, two tramadol-treated groups (30 mg/kg and 60 mg/kg), two co-administration groups (tramadol + 3.5 mg/kg zinc), and a zinc-only control. All administrations were oral for 49 days, followed by a mating study and fertility assessment. Results consistently showed that zinc significantly mitigated the adverse effects of tramadol on male fertility parameters. These findings suggest zinc supplementation could be a beneficial intervention against tramadol-induced reproductive toxicity.

Keywords

Zinc, Tramadol, Fertility, Antioxidants, Wistar Rats, Male Reproduction

Citations

IRE Journals:
Ufuoma Joy Ejite , Prof. Ologhaguo M Adienbo "Effects of Zinc on Fertility Parameters in Tramadol-Treated Male Wistar Rats" Iconic Research And Engineering Journals Volume 8 Issue 11 2025 Page 2005-2008

IEEE:
Ufuoma Joy Ejite , Prof. Ologhaguo M Adienbo "Effects of Zinc on Fertility Parameters in Tramadol-Treated Male Wistar Rats" Iconic Research And Engineering Journals, 8(11)