Current Volume 8
Abstract
Schiff bases, characterized by their azomethine group (-C=N-), are synthesized through the condensation of primary amines with carbonyl compounds, and their ability to form stable complexes with various metal ions has been extensively studied, revealing a broad spectrum of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic properties. The versatility of Schiff bases as ligands allows for the formation of both mononuclear and binuclear metal complexes, each exhibiting unique structural and electronic characteristics that contribute to their diverse pharmacological profiles. Recent studies have focused on the synthesis and characterization of these metal-Schiff base complexes, aiming to enhance their biological efficacy and selectivity. For instance, modifications in the ligand framework, such as the introduction of electron-donating or withdrawing groups, have been shown to influence the stability and reactivity of the resulting complexes, thereby affecting their interaction with biological targets. Additionally, the choice of metal ion plays a crucial role in determining the biological activity of the complex, with transition metals like copper, nickel, and zinc being commonly employed due to their favorable coordination chemistry and biological relevance. The development of these metal-Schiff base complexes has opened new avenues in medicinal chemistry, particularly in the design of novel therapeutic agents with improved efficacy and reduced side effects. However, challenges remain in understanding the precise mechanisms underlying their biological activities and in optimizing their pharmacokinetic and pharmacodynamic properties for clinical application. Future research directions include the exploration of Schiff base complexes with less common metals, the investigation of their interactions at the molecular level using advanced spectroscopic and computational techniques, and the assessment of their therapeutic potential in vivo. By addressing these challenges, the full potential of metal-Schiff base complexes in drug development can be realized, contributing significantly to the advancement of medicinal chemistry and the development of new treatments for various diseases.
Keywords
Schiff bases, Metal complexes, Azomethine group, biological activities, Transition metals, Medicinal chemistry
Citations
IRE Journals:
Dr. N. Y. Badannavar
"Metal Complexes with Schiff Bases: Data Collection and Recent Developments" Iconic Research And Engineering Journals Volume 5 Issue 5 2021 Page 338-348
IEEE:
Dr. N. Y. Badannavar
"Metal Complexes with Schiff Bases: Data Collection and Recent Developments" Iconic Research And Engineering Journals, 5(5)
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
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