Blood urea reducing effects of ethanolic extracts of yellow monkey kola fruit (Cola lepidota) seeds on ibuprofen-induced hyperuremia in albino rats.
Abstract
Plants are the richest sources of drugs used in traditional medicine, modern medicines, nutraceuticals, food supplements, pharmaceutical intermediates, and chemical entities for synthetic drugs. There has been a problem over the years in obtaining a stable treatment and management regimens for renal diseases using traditional medicines. Blood urea-reducing effects of yellow Monkey kola (Cola lepidota) seed ethanolic extract on ibuprofen-induced hyperuremic rats were studied. Albino rats weighing between 200 to 206 g were investigated in groups using 200 - 800 mg/kg weight of yellow Monkey kola seed extract and the sample was examined for serum urea using Randox diagnostic kits and statistically analyzed using statistical package for social science (SPSS) windows, version 20.0. The results were expressed as the Mean ± SD. The results for the serum urea concentrations of untreated diabetic rats, and treated rats showed a significant (P < 0.05) progressive decrease from 200 - 800 mg/kg when compared to the control rats. This study confirms the hypouremic effects of yellow Monkey kola (Cola lepidota) seed extract. The reduced serum urea concentration could be attributed to the nephroprotective activities of the rich flavonoids content in yellow Monkey kola seed extract (Vargas et al., 2018) and also due to the high fiber and low carbohydrate contents in yellow Monkey kola seed extract. Based on this, it is recommended that further studies be conducted to authenticate the pharmacodynamic pathways by which yellow Monkey kola seed extract reduces urea levels.
Keywords
Uremia, Hyperuremia, Yellow Monkey Kola, Renal Diseases, Ibuprofen.
Citations
IRE Journals:
Owo Gogo James , Kpomah E. Dennis
"Blood urea reducing effects of ethanolic extracts of yellow monkey kola fruit (Cola lepidota) seeds on ibuprofen-induced hyperuremia in albino rats." Iconic Research And Engineering Journals Volume 6 Issue 12 2023 Page 323-327
IEEE:
Owo Gogo James , Kpomah E. Dennis
"Blood urea reducing effects of ethanolic extracts of yellow monkey kola fruit (Cola lepidota) seeds on ibuprofen-induced hyperuremia in albino rats." Iconic Research And Engineering Journals, 6(12)
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