Blood urea reducing effects of ethanolic extracts of yellow monkey kola fruit (Cola lepidota) seeds on ibuprofen-induced hyperuremia in albino rats.

References

[1] Bishop, M.L.,Fody, E.P., Schoeff, L.E. (2010). Clinical Chemistry Techniques, Principles, Correlations (6th ed.). Lippincot Williams and Wilkins, 268, ISBN-9780781790451.

[2] Brink, M. (2007). Cola laterita . schum. In: Louppe D., Oteng-Amoako, A.A., Brink,M. editors. Prota 7(1): Tmbers/Bois d’oeuvre I. (CD-Rom). Wageningen, Netherlands,. Prota programme.

[3] Cheng, C., Zeng, Y., Xu, J., Zheng, H., Liu, J., Fan, R., Zhu, W., Yuan, L., Qin, Y., Chen,S., Zhou, Y., Wu, Y., Wan, J., Mi, M., and Wang, J. (2016). Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 2, 1232-1242.

[4] Cox, M. (2013). Lehninger Principles of Biochemistry. Freeman. ISBN-9781429234146.

[5] Ekweogu, C.N, Nwankpa, J.N, Egwurugwu, C.C, Etteh, P.C, Ugwuezumba, O.G, Chukwuemeka, O.G. (2018). Effects of Ethanol Extracts of Cola lepidota Seed on Lipid Profile and Haematological Parameters of Albino Wistar Rats. International Journal of Current Microbiology and Applied Science, 7(3):3178-3186.

[6] Ene-Obong, H.N, Okudu, H.O, Asumugha, U.V. (2016). Nutrient and phytochemical composition of two varieties of Monkey kola (Cola parchycarpa and Cola lepidota): An underutilised fruit. Food Chemistry, 193:154-9.

[7] Ene-Obong, H.N, Okudu, H.O. (2015).The Chemical and Sensory Properties of Jam Developed from two Varieties of Monkey kola (Cola parchycarpa and Cola lepidota).

[8] MacDonald, R.S., Steel-Goodwin, L., Smith, R.J. Influence of Dietary Fiber on Insulin Receptors in Rat Intestinal Mucosa. Annals of Nutrition and Metabolism, 1991, 35, 328-338.

[9] Meregini, A.O.A,.(2005). Some endangered plants producing edible fruits and seeds in Southeastern Nigeria. Fruits. 60:211-220.

[10] Meyer, T.W., Hostetter, T.H. (2014). Approaches to Uremia. New England Journal of Medicine, 25(10), 2151-2158.

[11] Meyer, T.W., Hostetter, T.H. (2007). Uremia. New England Journal of Medicine, 357(13), 1316-1325.

[12] Ochei, J., Kolhatktar, A. (2000). Lipids and Protein. In: Medical Laboratory Science: Theory and Practice, McGrawHill Publishing Co Ltrd., New Delhi, 311-347.

[13] Ogbu, J.U., Umeokechukwu, C.E. (2014).Aspects of fruit biology of here wild edible Monkey kola species fruits (Cola spp: Malvaceae). Annual Research & Review in Biology, 4(12):2007-2014.

[14] Oranusi, S., Onibokun, A., Afolabi, O., Okpalaiiaku, C. (2020).Chemical, Microbial and Antioxidant Activity of Cola lepidota K. Schum fruits, Czech Journal of Food Sciences, 38(1), 11-19.

[15] Parekhi, J., Jadeja, D., and Chanda, S. (2005). Efficiency of Aqueous and Methanolic Extract of Some Medical Plants for Potential Antibiotic Activities. Turkey Journal of Biology, 25, 203-210.

[16] Rigalleau, V., Gin, H. (2005). Carbohydrate metabolism in uraemia. Current Opinion in Clinical Nutrition and Metabolic Care, 8:463-469.

[17] Saad, J., Mathew, D. (2022). Nonsteroidal Anti-Inflammatory Drug Toxicity. In: StatPearls (Internet). Treasure Island (FL): StatPearls Publishing.

[18] Shinohara, K., Shoji, T., Emoto, M., Tahara, H., Koyama, H., Ishimura, E. Insulin resistance as a predictor of cardiovascular mortality in patients with end-stage renal disease. (2002). Journal of the American Society of Nephrology, 13:1894-1900.

[19] Sofowora, A.E. (1991). Pharmacological Evaluation of African Plants. West African Journal of Pharmacology, 19, 51-54.

[20] Vargas, F.,Romecin, P., Garcia-Guillen, A.L., Wangesteen, R, Vargas-Tendoro, Paredes, M.D., Atucha, N.M. Garcia-EStan, J. (2018). Flavonoids in Kidney Health and Disease. Front Physiology, 394.

[21] Vasudevan, D.M., Sreekumari, S., Vaidyanathan, K. (2011). Textbook of Biochemistry for Medical Students. 6th Edition, Jaypee Brothers Medical Publishers Ltd., New Delhi, 181-323.

[22] Zemaitis, M.R., Foris, L.A., Katta, S., Bashir, K. (2022). Uremia. . In: StatPearls (Internet). Treasure Island (FL): StatPearls Publishing.

@article{1704635,
      author = {Owo Gogo James, Kpomah E. Dennis},
      title = {Blood urea reducing effects of ethanolic extracts of yellow monkey kola fruit (Cola lepidota) seeds on ibuprofen-induced hyperuremia in albino rats.},
      journal = {Iconic Research And Engineering Journals},
      year = {2023},
      volume = {6},
      number = {12},
      pages = {323-327},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1704635.pdf},
      abstract = {Plants are the richest sources of drugs used in traditional medicine, modern medicines, nutraceuticals, food supplements, pharmaceutical intermediates, and chemical entities for synthetic drugs. There has been a problem over the years in obtaining a stable treatment and management regimens for renal diseases using traditional medicines. Blood urea-reducing effects of yellow Monkey kola (Cola lepidota) seed ethanolic extract on ibuprofen-induced hyperuremic rats were studied. Albino rats weighing between 200 to 206 g were investigated in groups using 200 - 800 mg/kg weight of yellow Monkey kola seed extract and the sample was examined for serum urea using Randox diagnostic kits and statistically analyzed using statistical package for social science (SPSS) windows, version 20.0. The results were expressed as the Mean ? SD. The results for the serum urea concentrations of untreated diabetic rats, and treated rats showed a significant (P < 0.05) progressive decrease from 200 - 800 mg/kg when compared to the control rats.  This study confirms the hypouremic effects of yellow Monkey kola (Cola lepidota) seed extract. The reduced serum urea concentration could be attributed to the nephroprotective activities of the rich flavonoids content in yellow Monkey kola seed extract (Vargas et al., 2018) and also due to the high fiber and low carbohydrate contents in yellow Monkey kola seed extract. Based on this, it is recommended that further studies be conducted to authenticate the pharmacodynamic pathways by which yellow Monkey kola seed extract reduces urea levels.},
      keywords = {Uremia, Hyperuremia, Yellow Monkey Kola, Renal Diseases, Ibuprofen.},
      month = {June},
  }