Current Volume 8
Viral Gene Therapy for Cardiovascular Diseases: Mechanisms, Vectors, Clinical Advances, And Future Directions
Abstract
Cardiovascular diseases (CVDs) sit atop the list leading to human mortality, thus preventing prompt attention by conventional pharmacologic or surgical treatments. Viral gene therapy has thus unfolded as a promising novel approach to treat the molecular causes of CVD by gene delivery, correction, or modulation in cardiac and vascular tissues. Therapeutic genes may be delivered via viral vectors such as adeno-associated virus (AAV), adenovirus, and lentivirus with great precision to cardiomyocytes, endothelial cells, and smooth muscle cells to treat heart failure, myocardial infarction, arrhythmias, and atherosclerosis, among others. Preclinical and clinical studies have established the efficacy of viral gene therapies in enhancing contractility, vascular regeneration, and the reversal of maladaptive remodeling. Clinical trials with some visibility to the world included those in which SERCA2a was targeted in chronic heart failure and VEGF for ischemic angiogenesis, which were deemed safe and moderately successful, yet the limitations of these studies bar their implementation as medicine. Immunogenicity of vectors, delivery efficacy, tissue specificity, limitations in packaging capacity, and maintenance of dent gene expression are among the major challenges. This article presents a comprehensive review of the mechanism, types of viral vectors, outcomes of clinical trials, targeting strategies, and perspectives for innovations in viral gene therapy for cardiovascular diseases. With continued evolution of gene editing tools and vector engineering, viral gene therapy is destined to emerge as a fundamental candidate in precision cardiology and regenerative cardiovascular medicine.
Keywords
Viral gene therapy, Cardiovascular disease, Adeno-associated virus, Lentivirus, SERCA2a, Myocardial infarction, Heart failure, Gene delivery, CRISPR, Vascular targeting
Citations
IRE Journals:
Nahal Vahedi , Zeinab Samiee Zafarghandi , Seyedeh Zoha Tabatabaei
"Viral Gene Therapy for Cardiovascular Diseases: Mechanisms, Vectors, Clinical Advances, And Future Directions" Iconic Research And Engineering Journals Volume 8 Issue 12 2025 Page 3-18
IEEE:
Nahal Vahedi , Zeinab Samiee Zafarghandi , Seyedeh Zoha Tabatabaei
"Viral Gene Therapy for Cardiovascular Diseases: Mechanisms, Vectors, Clinical Advances, And Future Directions" Iconic Research And Engineering Journals, 8(12)
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
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