The Role of Gut Microbiota Dysbiosis in the Pathogenesis and Management of Diabetes Mellitus
Abstract
It has been found that diabetes mellitus a worldwide metabolic dilemma characterized by persistent hyperglycemia is progressively linked to changes in the intestinal microbiome. The gut microbiota, a complex ecosystem of microorganisms found in the gastrointestinal tract, plays a crucial role in maintaining metabolic homeostasis. New evidence has also emphasized the role and importance of the gut-pancreatic axis in regulating glucose homeostasis with dysbiosis leaving the ability to secrete and act on insulin compromised due to inflammatory mechanisms, aberration of incretin response, and changes in short-chain fatty acid production. This review summarizes the existing data associating the gut microbiota disproportion with the pathophysiology of diabetes mellitus (DM) and discusses the potential of restoring a microbiota balance using therapeutic options. Probiotics, prebiotics, diet, and fecal microbiota transplantation have demonstrated the potential to affect glycemic control by improving insulin sensitivity and affecting host metabolism. Along with these encouraging results, it is necessary to conduct additional studies to understand the causal links and lay a foundation for understanding personalized, microbiota-directed treatment. This literature review underlines the topicality of manipulation of gut microbiota in diabetes management and proposes further directions for microbiome-guided interventions.
Keywords
Gut microbiota, Gut–pancreas axis, Glycemic control, Diabetes mellitus, Dysbiosis
Citations
IRE Journals:
Tamanna Akter , Bibi Ayesa , Mst Shahinur Begum; Farheen Iqbal , Banasree Roy Urmi; Aditta Das , Sayed Hossain; Md. Jobaer Rahman Rashed
"The Role of Gut Microbiota Dysbiosis in the Pathogenesis and Management of Diabetes Mellitus" Iconic Research And Engineering Journals Volume 7 Issue 10 2024 Page 568-576
IEEE:
Tamanna Akter , Bibi Ayesa , Mst Shahinur Begum; Farheen Iqbal , Banasree Roy Urmi; Aditta Das , Sayed Hossain; Md. Jobaer Rahman Rashed
"The Role of Gut Microbiota Dysbiosis in the Pathogenesis and Management of Diabetes Mellitus" Iconic Research And Engineering Journals, 7(10)
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