Abstract
The wide use of digital technology has introduced a new class of pervasive, chronic stressors to the mankind. While the psychological and social consequences are well-documented, the fundamental molecular and cellular mechanisms through which digital stress impacts human physiology were still not clearly understood. This review paper provides a comprehensive analysis of the biological pathways that mediate the effects of digital technologies apart from behavioural perspective. It is evident that the constant connectivity and digital stimuli activate the hypothalamic-pituitary-adrenal (HPA) axis, which further leads to continuous glucocorticoid exposure and downstream cellular changes. Neurobiological effects of these modifications include modifications to the dopamine-reward system and additional stimulation of neuroinflammation through the activation of microglia. Furthermore, these activities result in systemic impacts such inflammation, oxidative stress, and changes to the gut-brain axis. Developing focused, physiologically based therapies to mitigate these impacts requires in-depth understanding of the molecular and cellular mechanisms. To address the biological impact of a digitally-intensive lifestyle, further research is required to find new biomarkers and create therapeutic approaches.
Keywords
Digital Stress, Neurobiology, Cortisol, Inflammation, Oxidative Stress, Microbiome, Cellular Mechanisms, Molecular Pathways.
Citations
IRE Journals:
G. Vidya Sagar Reddy "Beyond the Screen: The Molecular and Cellular Mechanisms of Digital Stress" Iconic Research And Engineering Journals Volume 9 Issue 3 2025 Page 883-888 https://doi.org/10.64388/IREV9I3-1710701-3191
IEEE:
G. Vidya Sagar Reddy
"Beyond the Screen: The Molecular and Cellular Mechanisms of Digital Stress" Iconic Research And Engineering Journals, 9(3) https://doi.org/10.64388/IREV9I3-1710701-3191
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
Important Links
For Authors
Volume 8:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 7:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 6:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 5:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 4:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 3:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12