Age-Specific Gut Microbiota Dysbiosis in Autoimmune Disease: A Comparative Analysis Between Pediatric and Adult Cohorts.
Abstract
Gut microbiota plays a fundamental role in regulating immune function and has been increasingly linked to the development of autoimmune diseases. This study compares the gut microbial composition and diversity in children and adults with autoimmune disorders to those of healthy controls. Stool samples were examined through 16S rRNA gene sequencing to assess microbial diversity, relative abundance of key taxa, and functional pathways potentially involved in immune dysregulation. The analysis revealed a marked decline in overall microbial diversity and notable alterations in bacterial groups, particularly Firmicute and Bacteroidetes, among patients with autoimmune conditions. Distinct age- related patterns were observed, underscoring differences in microbial signatures between children and adults. These findings highlight the crucial role of gut microbiota in autoimmune pathogenesis and suggest the potential of age-specific microbiota- targeted interventions. Continued longitudinal and mechanistic research is required to translate these insights into effective clinical application.
Citations
IRE Journals:
Nida Marriyam , Saniya Sultana
"Age-Specific Gut Microbiota Dysbiosis in Autoimmune Disease: A Comparative Analysis Between Pediatric and Adult Cohorts." Iconic Research And Engineering Journals Volume 9 Issue 4 2025 Page 535-539
IEEE:
Nida Marriyam , Saniya Sultana
"Age-Specific Gut Microbiota Dysbiosis in Autoimmune Disease: A Comparative Analysis Between Pediatric and Adult Cohorts." Iconic Research And Engineering Journals, 9(4)
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