Home / Current Issue / Paper 1712583
ALZMIND: Machine Learning- Powered Early Diagnosis and Accurate Testing of Alzheimer?s Disease
Subject area: Science,Engineering and Technology · Area of research: Machine Learning
Abstract
Alzheimer?s disease (AD) is a chronic neurodegenerative disorder that progressively deteriorates memory, cognition, and behavioral stability. The absence of reliable early diagnostic mechanisms often results in delayed detection and treatment inefficiency. This paper presents ALZMIND, a machine learning-driven digital health platform developed to facilitate early diagnosis and precise cognitive testing for Alzheimer?s disease. The system architecture comprises four integrated components: (i) user registration, authentication, and informed consent management; (ii) role-specific dashboards enabling researchers and patients to monitor and visualize cognitive performance; (iii) a clinical trial matching module that leverages user data and eligibility criteria to recommend relevant ongoing studies; and (iv) a cognitive assessment module employing an interactive memory game and quiz to evaluate recall accuracy, attention span, and recognition ability. The data obtained are analyzed using supervised learning algorithms to detect deviations indicative of early cognitive decline. By combining predictive analytics with user interaction data, ALZMIND aims to enhance diagnostic precision, accelerate research participation, and contribute to early intervention strategies. Experimental results and system evaluation demonstrate the feasibility of integrating artificial intelligence within clinical workflows for neurodegenerative disease management.
Keywords
Alzheimer?s Disease, Machine Learning, Cognitive Assessment, Early Diagnosis, Clinical Trial Matching, Predictive Analytics, Digital Health, Neurodegenerative Disorders
References
[1] Tong, T., Gray, K., Gao, Q., Chen, L., Rueckert, D., “Multi-Modal Classification of Alzheimer’s Disease Using Novel Grading Biomarker,” Medical Image Computing and Computer-Assisted Intervention (MICCAI), vol. 10433, pp. 338–346, 2017.
[2] Mahyoub, F., Amoon, M., & Ahmed, A., “Ranking of Alzheimer’s Disease Risk Factors Using Machine Learning Algorithms,” International Journal of Advanced Computer Science and Applications (IJACSA), vol. 9, no. 5, pp. 212–219, 2018.
[3] Vinutha, K. S., et al., “Prediction of Alzheimer’s Disease Using Convolutional Neural Network (CNN) on MRI Images,” IEEE International Conference on Computational Intelligence and Data Science (ICCIDS), 2024.
[4] Vimaladevi, S., Anandaraj, J., & Priya, M., “Detection of Alzheimer’s Disease Using Handwriting Dynamics and Machine Learning Techniques,” Journal of Computational and Cognitive Neuroscience, vol. 6, no. 2, 2024.
[5] Tung, J. Y., et al., “Everyday Technologies for Alzheimer’s Care (ETAC): Pervasive Computing for Cognition Assessment,” Proceedings of the IEEE Pervasive Health Conference, pp. 1–8, 2013.
[6] World Health Organization (WHO), Dementia Fact Sheet, 2023. [Online]. Available:
[7] Alzheimer’s Disease International (ADI), World⁶ Alzheimer Report 2023: Reducing Dementia Risk, London, U.K., 2023.
[8] Scikit-learn Developers, “Random Forest Classifier Documentation,” Scikit-learn: Machine Learning in
[9] Grinberg, M., Flask Web Development: Developing Web Applications with Python, 2nd ed., O’Reilly Media, 2018.
[10] SQLAlchemy Documentation, “Object Relational Mapper (ORM) Guide,” [Online]. Available: https://docs.sqlalchemy.org.
[11] ReportLab Developers, “ReportLab User Guide,” ReportLab Toolkit, Version 3.6, 2024. [Online]. Available: https://www.reportlab.com/documentation.
[12] Pedregosa, F., et al., “Scikit-learn: Machine Learning in Python,” Journal of Machine Learning Research, vol. 12, pp. 2825–2830, 2011.
[13] United States Department of Health & Human Services (HHS), “HIPAA Privacy Rule Summary,” 2023. [Online]. Available: https://www.hhs.gov/hipaa.
[14] Nielsen, J., “Usability Engineering,” Morgan Kaufmann Publishers, 1993.
[15] Sauro, J., and Lewis, J. R., “Quantifying the User Experience: Practical Statistics for User Research,” Elsevier/Morgan Kaufmann, 2016.
[16] GitHub, “Flask-Bcrypt, Flask-Login, Flask-Migrate, Flask-CORS: Official Documentation,” [Online]. Available: https://flask.palletsprojects.com.
[17] NumPy Developers, “NumPy User Guide,” [Online]. Available: https://numpy.org/doc/
How to cite this paper
@article{1712583,
author = {Zoya Muskaan, Vidyavathi GK, Tasmia Nida, Syed Nizamuddin Quadri, Ganesh S},
title = {ALZMIND: Machine Learning- Powered Early Diagnosis and Accurate Testing of Alzheimer?s Disease},
journal = {Iconic Research And Engineering Journals},
year = {2025},
volume = {9},
number = {6},
pages = {285-291},
issn = {2456-8880},
url = {https://www.irejournals.com/formatedpaper/1712583.pdf},
abstract = {Alzheimer?s disease (AD) is a chronic neurodegenerative disorder that progressively deteriorates memory, cognition, and behavioral stability. The absence of reliable early diagnostic mechanisms often results in delayed detection and treatment inefficiency. This paper presents ALZMIND, a machine learning-driven digital health platform developed to facilitate early diagnosis and precise cognitive testing for Alzheimer?s disease. The system architecture comprises four integrated components: (i) user registration, authentication, and informed consent management; (ii) role-specific dashboards enabling researchers and patients to monitor and visualize cognitive performance; (iii) a clinical trial matching module that leverages user data and eligibility criteria to recommend relevant ongoing studies; and (iv) a cognitive assessment module employing an interactive memory game and quiz to evaluate recall accuracy, attention span, and recognition ability. The data obtained are analyzed using supervised learning algorithms to detect deviations indicative of early cognitive decline. By combining predictive analytics with user interaction data, ALZMIND aims to enhance diagnostic precision, accelerate research participation, and contribute to early intervention strategies. Experimental results and system evaluation demonstrate the feasibility of integrating artificial intelligence within clinical workflows for neurodegenerative disease management. },
keywords = {Alzheimer?s Disease, Machine Learning, Cognitive Assessment, Early Diagnosis, Clinical Trial Matching, Predictive Analytics, Digital Health, Neurodegenerative Disorders},
month = {December},
doi = {https://doi.org/10.64388/IREV9I6-1712583}
}