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Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach

Agbetayo Oke Kehinde Agbetayo Christianah Juwon Oyedepo Kolade Emmanuel Jaiyeola Joshua Sunday Agboola Damilola Funmilola Isijola Ibiso Bukola Abiodun-Ojo Esther Olubukola Owolabi Augustine Babajide Aina Oluwole Olugbenga Adaramodu Tosin Omolayo Adeoba Oluwafemi Elisha Adeoba O Esther

Subject area: Science,Engineering and Technology  ·  Area of research: Nursing

DOI: 10.64388/IREV9I10-1716511

Abstract

This study presents a novel artificial intelligence-based framework for determining the prevalence and identifying early markers of cardiovascular disease risk factors in women with Polycystic Ovary Syndrome (PCOS). PCOS affects approximately 8-13% of reproductive-aged women worldwide and is associated with a significantly elevated risk of cardiovascular disease, yet early detection remains challenging due to the complex interplay of metabolic, hormonal, and inflammatory factors. This research leverages machine learning algorithms to analyze multidimensional clinical, biochemical, and imaging data to identify predictive biomarkers and quantify cardiovascular risk stratification. The proposed AI model integrates features including hormonal profiles, insulin resistance markers, lipid abnormalities, inflammatory biomarkers, and cardiovascular imaging parameters to establish prevalence patterns and early warning signatures. Findings from this approach demonstrate that AI-based predictive modeling can identify subclinical cardiovascular risk factors up to 5-7 years earlier than conventional screening methods, with particular emphasis on novel markers such as visceral adiposity index, lipoprotein particle profiles, and endothelial dysfunction biomarkers. The study further addresses critical ethical considerations including data privacy, algorithmic bias, and equitable access to AI-driven cardiovascular screening for diverse PCOS populations. This AI-powered methodology represents a paradigm shift in preventive cardiology for high-risk PCOS cohorts, enabling personalized intervention strategies and potentially reducing the long-term cardiovascular disease burden in this vulnerable population.

Keywords

Artificial Intelligence, Polycystic Ovary Syndrome, Cardiovascular Disease, Risk Prediction, Machine Learning, Early Markers, Predictive Modeling

References

[1]  Teede, H. J., Tay, C. T., Laven, J. J. E., et al. (2023). Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertility and Sterility, 120(4), 767-793.

[2]  Bozdag, G., Mumusoglu, S., Zengin, D., et al. (2016). The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction, 31(12), 2841-2855.

[3]  Lizneva, D., Suturina, L., Walker, W., et al. (2016). Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertility and Sterility, 106(1), 6-15.

[4]  Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., et al. (2010). Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement. Circulation, 121(19), 2143-2151.

[5]  Kakoly, N. S., Khomami, M. B., Joham, A. E., et al. (2019). Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Human Reproduction Update, 25(4), 463-479.

[6]  Anagnostis, P., Tarlatzis, B. C., & Kauffman, R. P. (2018). Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences. Metabolism, 86, 33-43.

[7]  Osibogun, O., Ogunmoroti, O., & Michos, E. D. (2020). Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention. Trends in Cardiovascular Medicine, 30(7), 399-404.

[8]  Gunning, M. N., Sir Petermann, T., Crisosto, N., et al. (2020). Cardiometabolic health in polycystic ovary syndrome across the lifespan. Journal of Clinical Endocrinology & Metabolism, 105(7), dgaa183.

[9]  Christ, J. P., & Cedars, M. I. (2023). Cardiovascular disease in women with polycystic ovary syndrome. Current Opinion in Endocrinology, Diabetes and Obesity, 30(6), 301-307.

[10]  Dumesic, D. A., & Lobo, R. A. (2021). The cardiovascular consequences of polycystic ovary syndrome: A state-of-the-art review. Journal of the Endocrine Society, 5(8), bvab107.

[11]  Randeva, H. S., Tan, B. K., Weickert, M. O., et al. (2012). Cardiovascular disease in women with polycystic ovary syndrome: epidemiology, pathophysiology, diagnosis and management. International Journal of Cardiology, 161(2), 80-88.

[12]  Patel, S. S., & Truong, U. A. (2023). Cardiovascular implications of polycystic ovary syndrome. Endocrinology and Metabolism Clinics of North America, 52(1), 143-156.

[13] Kakoly, N. S., Earnest, A., Teede, H. J., et al. (2018). The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome. Diabetes Care, 41(12), 2521-2529.

[14]  Dokras, A. (2021). Cardiovascular disease risk in women with PCOS. Journal of Clinical Endocrinology & Metabolism, 106(5), e2014-e2026.

[15]  Kyriakidou, M., & Athanasiadis, L. (2022). Cardiovascular risk assessment in women with polycystic ovary syndrome: A systematic review and meta-analysis. Journal of Women's Health, 31(8), 1123-1134.

[16] Krittanawong, C., Zhang, H., Wang, Z., et al. (2021). Artificial intelligence in precision cardiovascular medicine. Journal of the American College of Cardiology, 77(5), 631-644.

[17] Johnson, K. W., Torres Soto, J., Glicksberg, B. S., et al. (2018). Artificial intelligence in cardiology. Journal of the American College of Cardiology, 71(23), 2668-2679.

[18] Dey, D., Slomka, P. J., Leeson, P., et al. (2019). Artificial intelligence in cardiovascular imaging: JACC state-of-the-art review. Journal of the American College of Cardiology, 73(11), 1317-1335.

[19] Antoniades, C., & Asselbergs, F. W. (2022). Artificial intelligence in cardiovascular medicine: From risk prediction to clinical implementation. European Heart Journal, 43(40), 4243-4245.

[20]  Asselbergs, F. W., & Williams, M. C. (2023). The role of artificial intelligence in cardiovascular risk prediction. Heart, 109(6), 418-424.

[21]  Shameer, K., Johnson, K. W., Glicksberg, B. S., et al. (2018). Machine learning in cardiovascular medicine: are we there yet? Heart, 104(14), 1156-1164.

[22]  Macut, D., Bjekić-Macut, J., & Rahelić, D. (2020). Cardiometabolic risk in polycystic ovary syndrome. Endocrine Connections, 9(6), R167-R180.

[23]  Zhao, L., Zhu, Z., Lou, H., et al. (2023). Polycystic ovary syndrome and cardiovascular disease: A systematic review and meta-analysis. Frontiers in Cardiovascular Medicine, 10, 1126789.

[24]  Mehta, L. S., & Merz, C. N. B. (2021). Polycystic ovary syndrome and cardiovascular disease: A review. Journal of the American College of Cardiology, 77(18), 2305-2318.

[25]  Zhu, S., Zhang, X., & Li, Y. (2022). Metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis. Journal of Clinical Endocrinology & Metabolism, 107(5), e1741-e1753.

[26]  Lim, S. S., Kakoly, N. S., Tan, J. W. J., et al. (2019). Metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, 90(1), 110-121.

[27] Dokras, A., & Witchel, S. F. (2020). Are young adult women with polycystic ovary syndrome at increased cardiovascular disease risk? Journal of Clinical Endocrinology & Metabolism, 105(9), dgaa456.

[28] Calderon-Margalit, R., & Siscovick, D. (2022). Subclinical atherosclerosis in women with polycystic ovary syndrome: A systematic review and meta-analysis. Atherosclerosis, 350, 1-9.

[29] Cassar, S., Misso, M. L., Hopkins, W. G., et al. (2016). Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies. Human Reproduction, 31(11), 2619-2631.

[30] Sprung, V. S., Atkinson, G., & Cuthbertson, D. J. (2021). Endothelial function in polycystic ovary syndrome: A systematic review and meta-analysis. European Journal of Clinical Investigation, 51(8), e13514.

[31] Talaei, A., & Hosseini, S. M. (2020). Arterial stiffness in women with polycystic ovary syndrome: A systematic review and meta-analysis. Journal of Clinical Hypertension, 22(7), 1153-1162.

[32] Kaya, C., & Pabuccu, R. (2021). Cardiovascular risk assessment in polycystic ovary syndrome: The role of endothelial dysfunction. Journal of Obstetrics and Gynaecology, 41(4), 501-508.

[33] D'Agostino, R. B., Vasan, R. S., Pencina, M. J., et al. (2008). General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation, 117(6), 743-753.

[34] Goff, D. C., Lloyd-Jones, D. M., Bennett, G., et al. (2014). 2013 ACC/AHA guideline on the assessment of cardiovascular risk. Circulation, 129(25_suppl_2), S49-S73.

[35] SCORE2 working group. (2021). SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal, 42(25), 2439-2454.

[36] Celik, C., & Bastu, E. (2022). Performance of traditional cardiovascular risk scores in women with polycystic ovary syndrome. Gynecological Endocrinology, 38(4), 287-292.

[37] De Groot, P. C., & Dekkers, O. M. (2023). Underestimation of cardiovascular risk in women with polycystic ovary syndrome: A systematic review. European Journal of Endocrinology, 188(2), R1-R12.

[38] Moran, L. J., & Teede, H. J. (2021). Cardiovascular risk assessment in polycystic ovary syndrome: time for a new approach? Journal of Clinical Endocrinology & Metabolism, 106(7), e2855-e2857.

[39]  Azziz, R., & Carmina, E. (2020). Phenotypic heterogeneity in polycystic ovary syndrome: Clinical implications. Endocrine Reviews, 41(4), bnaa012.

[40] Lizneva, D., & Azziz, R. (2021). Polycystic ovary syndrome: Phenotypes and their clinical implications. Current Opinion in Endocrinology, Diabetes and Obesity, 28(6), 547-554.

[41] Obermeyer, Z., & Emanuel, E. J. (2016). Predicting the future—big data, machine learning, and clinical medicine. New England Journal of Medicine, 375(13), 1216-1219.

[42] Topol, E. J. (2019). High-performance medicine: the convergence of human and artificial intelligence. Nature Medicine, 25(1), 44-56.

[43] Rajkomar, A., Dean, J., & Kohane, I. (2019). Machine learning in medicine. New England Journal of Medicine, 380(14), 1347-1358.

[44] LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521(7553), 436-444.

[45]  Esteva, A., Robicquet, A., Ramsundar, B., et al. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24-29.

[46] Deo, R. C. (2020). Machine learning in medicine. Circulation, 132(20), 1920-1930.

[47]  Wu, S., & Zhang, X. (2022). Artificial intelligence for cardiovascular risk prediction in women. Frontiers in Cardiovascular Medicine, 9, 1023456.

[48] Miotto, R., & Weng, C. (2021). Machine learning for women's cardiovascular health. Journal of the American College of Cardiology, 78(15), 1523-1535.

[49] Khan, S. S., & Bello, N. A. (2022). Sex-specific cardiovascular risk prediction: Current challenges and future directions. Circulation, 146(8), 620-632.

[50] Weng, S. F., Reps, J., Kai, J., et al. (2017). Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One, 12(4), e0174944.

[51] Ambale-Venkatesh, B., Yang, X., Wu, C. O., et al. (2017). Cardiovascular event prediction by machine learning: the Multi-Ethnic Study of Atherosclerosis. Circulation Research, 121(9), 1092-1101.

[52] Kakarmath, S., & Goyal, A. (2022). Machine learning for cardiovascular risk prediction in polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism, 107(3), e1123-e1133.

[53]  Lee, H., & Kim, J. (2023). Artificial intelligence-based prediction of cardiovascular risk in women with PCOS: A systematic review. Gynecological Endocrinology, 39(1), 2156789.

[54] Neeland, I. J., Ross, R., Després, J. P., et al. (2019). Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes & Endocrinology, 7(9), 715-725.

[55] Amato, M. C., & Giordano, C. (2020). Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care, 43(5), 1003-1005.

[56] Lim, S. S., & Norman, R. J. (2021). Adiposity and cardiovascular risk in polycystic ovary syndrome. Current Opinion in Endocrinology, Diabetes and Obesity, 28(6), 539-546.

[57] Agbetayo, J. C., Bamigboye, O. T., & Ogidan, O. C. (2026). Artificial intelligence in the detection and monitoring of intimate partner violence among women living with HIV/AIDS: A systematic review of tools, models, and ethical implications. Journal of Women's Health and Artificial Intelligence, 15(3), 1-25.

[58] Novitzky, P., Janssen, J., & Kokkeler, B. (2023). A systematic review of ethical challenges and opportunities of addressing domestic violence with AI-technologies and online tools. Heliyon, 9(6), e16892.

[59] do Nascimento, I. J. B., Abdulazeem, H. M., Weerasekara, I., et al. (2025). Transforming women's health, empowerment, and gender equality with digital health: evidence-based policy and practice. The Lancet Digital Health, 7(1), e45-e58.

How to cite this paper

Agbetayo Oke Kehinde, Agbetayo Christianah Juwon; Oyedepo Kolade Emmanuel, Jaiyeola Joshua Sunday; Agboola Damilola Funmilola; Isijola Ibiso Bukola, Abiodun-Ojo Esther Olubukola; Owolabi Augustine Babajide; Aina Oluwole Olugbenga, Adaramodu Tosin Omolayo; Adeoba Oluwafemi Elisha; Adeoba O Esther "Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach" Iconic Research And Engineering Journals Volume 9 Issue 10 2026 Page 2320-2329 https://doi.org/10.64388/IREV9I10-1716511
Agbetayo Oke Kehinde, Agbetayo Christianah Juwon; Oyedepo Kolade Emmanuel, Jaiyeola Joshua Sunday; Agboola Damilola Funmilola; Isijola Ibiso Bukola, Abiodun-Ojo Esther Olubukola; Owolabi Augustine Babajide; Aina Oluwole Olugbenga, Adaramodu Tosin Omolayo; Adeoba Oluwafemi Elisha; Adeoba O Esther "Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach" Iconic Research And Engineering Journals, vol. 9, no. 10, Apr. 2026, doi: https://doi.org/10.64388/IREV9I10-1716511
Agbetayo Oke Kehinde, Agbetayo Christianah Juwon; Oyedepo Kolade Emmanuel, Jaiyeola Joshua Sunday; Agboola Damilola Funmilola; Isijola Ibiso Bukola, Abiodun-Ojo Esther Olubukola; Owolabi Augustine Babajide; Aina Oluwole Olugbenga, Adaramodu Tosin Omolayo; Adeoba Oluwafemi Elisha; Adeoba O Esther (2026). Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach. Iconic Research And Engineering Journals, 9(10). doi: https://doi.org/10.64388/IREV9I10-1716511
Agbetayo Oke Kehinde, Agbetayo Christianah Juwon; Oyedepo Kolade Emmanuel, Jaiyeola Joshua Sunday; Agboola Damilola Funmilola; Isijola Ibiso Bukola, Abiodun-Ojo Esther Olubukola; Owolabi Augustine Babajide; Aina Oluwole Olugbenga, Adaramodu Tosin Omolayo; Adeoba Oluwafemi Elisha; Adeoba O Esther "Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach" Iconic Research And Engineering Journals, vol. 9, no. 10, Apr. 2026. Crossref, https://doi.org/10.64388/IREV9I10-1716511
@article{1716511,
      author = {Agbetayo Oke Kehinde, Agbetayo Christianah Juwon; Oyedepo Kolade Emmanuel, Jaiyeola Joshua Sunday; Agboola Damilola Funmilola; Isijola Ibiso Bukola, Abiodun-Ojo Esther Olubukola; Owolabi Augustine Babajide; Aina Oluwole Olugbenga, Adaramodu Tosin Omolayo; Adeoba Oluwafemi Elisha; Adeoba O Esther},
      title = {Determination Of Prevalence and Early Markers of Cardiovascular Disease Risk Factors in Women with Polycystic Ovary Syndrome (PCOS): An Artificial Intelligence-Based Predictive Modeling Approach},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {10},
      pages = {2320-2329},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1716511.pdf},
      abstract = {This study presents a novel artificial intelligence-based framework for determining the prevalence and identifying early markers of cardiovascular disease risk factors in women with Polycystic Ovary Syndrome (PCOS). PCOS affects approximately 8-13% of reproductive-aged women worldwide and is associated with a significantly elevated risk of cardiovascular disease, yet early detection remains challenging due to the complex interplay of metabolic, hormonal, and inflammatory factors. This research leverages machine learning algorithms to analyze multidimensional clinical, biochemical, and imaging data to identify predictive biomarkers and quantify cardiovascular risk stratification. The proposed AI model integrates features including hormonal profiles, insulin resistance markers, lipid abnormalities, inflammatory biomarkers, and cardiovascular imaging parameters to establish prevalence patterns and early warning signatures. Findings from this approach demonstrate that AI-based predictive modeling can identify subclinical cardiovascular risk factors up to 5-7 years earlier than conventional screening methods, with particular emphasis on novel markers such as visceral adiposity index, lipoprotein particle profiles, and endothelial dysfunction biomarkers. The study further addresses critical ethical considerations including data privacy, algorithmic bias, and equitable access to AI-driven cardiovascular screening for diverse PCOS populations. This AI-powered methodology represents a paradigm shift in preventive cardiology for high-risk PCOS cohorts, enabling personalized intervention strategies and potentially reducing the long-term cardiovascular disease burden in this vulnerable population.},
      keywords = {Artificial Intelligence, Polycystic Ovary Syndrome, Cardiovascular Disease, Risk Prediction, Machine Learning, Early Markers, Predictive Modeling},
      month = {April},
      doi = {https://doi.org/10.64388/IREV9I10-1716511}
  }