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1717227PublishedVol 9 · Issue 11

Malaria Detection Using an Improved AlexNet-Based Deep Learning Model

M. Phanindra K. Venkata Siva Sai Sreeja P. Nikhil

Subject area: Science,Engineering and Technology  ·  Area of research: Artificial Intelligence / Machine Learning

DOI: https://doi.org/10.64388/IREV9I11-1717227

Abstract

Diagnosing malaria still relies heavily on microscope examination of blood smears — which works, but is slow, hard to scale, and only as good as the person doing it. This paper describes a deep learning pipeline for binary malaria cell screening built on a modified AlexNet CNN. We used the public NIH/Kaggle malaria cell-image dataset, resized everything to 100×100 RGB patches, applied live augmentation, and trained a regularized CNN with batch normalization and dropout. Beyond just reporting accuracy, we evaluated the model with confusion matrices, ROC-AUC, precision-recall curves, calibration plots, and Grad-CAM heatmaps. We also compare the approach against a recent two-stage YOLOv4/DenseNet-121 system. This model doesn't do whole-slide detection or species identification — it's a clean, reproducible infected-vs-uninfected screener that can be understood, explained, and built on.

Keywords

Malaria Detection, Alexnet, Convolutional Neural Network, Grad-CAM, Medical Image Classification, Binary Screening.

How to cite this paper

M. Phanindra, K. Venkata Siva Sai Sreeja, P. Nikhil "Malaria Detection Using an Improved AlexNet-Based Deep Learning Model" Iconic Research And Engineering Journals Volume 9 Issue 11 2026 Page 472-474 https://doi.org/10.64388/IREV9I11-1717227
M. Phanindra, K. Venkata Siva Sai Sreeja, P. Nikhil "Malaria Detection Using an Improved AlexNet-Based Deep Learning Model" Iconic Research And Engineering Journals, vol. 9, no. 11, May. 2026, doi: https://doi.org/10.64388/IREV9I11-1717227
M. Phanindra, K. Venkata Siva Sai Sreeja, P. Nikhil (2026). Malaria Detection Using an Improved AlexNet-Based Deep Learning Model. Iconic Research And Engineering Journals, 9(11). doi: https://doi.org/10.64388/IREV9I11-1717227
M. Phanindra, K. Venkata Siva Sai Sreeja, P. Nikhil "Malaria Detection Using an Improved AlexNet-Based Deep Learning Model" Iconic Research And Engineering Journals, vol. 9, no. 11, May. 2026. Crossref, https://doi.org/10.64388/IREV9I11-1717227
@article{1717227,
      author = {M. Phanindra, K. Venkata Siva Sai Sreeja, P. Nikhil},
      title = {Malaria Detection Using an Improved AlexNet-Based Deep Learning Model},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {11},
      pages = {472-474},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1717227.pdf},
      abstract = {Diagnosing malaria still relies heavily on microscope examination of blood smears — which works, but is slow, hard to scale, and only as good as the person doing it. This paper describes a deep learning pipeline for binary malaria cell screening built on a modified AlexNet CNN. We used the public NIH/Kaggle malaria cell-image dataset, resized everything to 100×100 RGB patches, applied live augmentation, and trained a regularized CNN with batch normalization and dropout. Beyond just reporting accuracy, we evaluated the model with confusion matrices, ROC-AUC, precision-recall curves, calibration plots, and Grad-CAM heatmaps. We also compare the approach against a recent two-stage YOLOv4/DenseNet-121 system. This model doesn't do whole-slide detection or species identification — it's a clean, reproducible infected-vs-uninfected screener that can be understood, explained, and built on.},
      keywords = {Malaria Detection, Alexnet, Convolutional Neural Network, Grad-CAM, Medical Image Classification, Binary Screening.},
      month = {May},
      doi = {https://doi.org/10.64388/IREV9I11-1717227}
  }