Formulation and Evaluation of Emulgel Containing Papaya Extract as Antibacterial Agent

References

[1] Aruoma OI. Medicinal plants: their role in health and biodiversity. Trans R Soc Trop Med Hyg. 2003;97(3):377–378.

[2] Ayoola GA, Coker HAB, Adesegun SA, et al. Phytochemical screening and antioxidant activities of some selected medicinal plants. Trop J Pharm Res. 2008;7(3):1019–1024.

[3] Baskaran C, Rathabai V, Karthick Raja SN. Efficacy of Carica papaya leaf extract on some bacterial and a fungal strain by well diffusion method. Asian Pac J Trop Dis. 2012;2(8):658–662.

[4] Bhowmik D, Gopinath H, Kumar PB, Duraivel S, Aravind G, Kumar KPS. Medicinal uses of Carica papaya. J Med Plants Stud. 2014;2(1):7–15.

[5] Devaraj VC, Krishna BG. Gastric antisecretory and cytoprotective effects of leaf extracts of Carica papaya L. in rats. J Chinese Integrative Med. 2011;9(10):1140–1148.

[6] Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulations: an update. Pharm Technol. 2002;26(9):84–102.

[7] Jarukamjorn K, Nemoto N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. J Health Sci. 2008;54(4):370–381.

[8] Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm J. 2012;20(1):63–67.

[9] Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 50th ed. Pune: Nirali Prakashan; 2015:A.1–A.19.

[10] Madan J, Singh R. Formulation and evaluation of aloe vera topical gels. Int J Pharm Sci. 2010;2(2):551–555.

[11] Mahdy AM, Mohamed SH. Assessment of the antimicrobial activity of papaya leaf extract against multidrug-resistant bacteria. J Pharm Pharmacol. 2021;9(2):45–52.

[12] Nayak BS, Patel KN. Physicochemical characterization and evaluation of carbopol 940-based topical emulgels. Int J Pharm Sci Rev Res. 2010;3(2):155–158.

[13] Owoyele BV, Adebukola OM, Funmilayo AA, Soladoye AO. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008;16(4):168–173.

[14] Singhal M, Rastogi A, Bhardwaj P. Emulgel: a novel approach for enhanced topical drug delivery. Int J Pharm Bio Sci. 2012;3(1):P-305–P-313.

[15] Voigt R. Pharmaceutical Technology. 5th ed. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 1994:333–370.

@article{1717485,
      author = {Savitri Gautam, Ashvani Kumar},
      title = {Formulation and Evaluation of Emulgel Containing Papaya Extract as Antibacterial Agent},
      journal = {Iconic Research And Engineering Journals},
      year = {2026},
      volume = {9},
      number = {11},
      pages = {886-892},
      issn = {2456-8880},
      url = {https://www.irejournals.com/formatedpaper/1717485.pdf},
      abstract = {The present study aimed to formulate and evaluate emulgel preparations containing papaya (Carica papaya L.) leaf extract as an antibacterial agent. Emulgels offer a dual advantage by combining the properties of both emulsions and gels, resulting in superior skin penetration and extended drug residence time. Three formulations (F1, F2, F3) were prepared with varying concentrations of papaya extract (5%, 10%, and 15% w/w) using Carbopol 940 as the gelling agent and a combination of Span 80 and Tween 80 as emulsifiers. The prepared emulgels were evaluated for physicochemical parameters including pH, viscosity, spreadability, homogeneity, and stability. Antibacterial activity was assessed against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) using the agar well diffusion method. In vitro drug release was studied using Franz diffusion cells. All formulations demonstrated acceptable pH values (6.71–6.85) and viscosities (6,500–9,400 cP) suitable for topical application. Formulation F3 (15% extract) exhibited the highest zone of inhibition of 23.1 mm against S. aureus and 21.4 mm against E. coli, and the highest cumulative drug release of 94% at 8 hours. The emulgels remained stable over 90 days of storage under accelerated conditions (40°C/75% RH). These results demonstrate that papaya extract emulgel is a promising topical antibacterial formulation with potential for clinical application in the management of skin infections.},
      keywords = {Carica Papaya, Emulgel, Antibacterial, Carbopol 940, Zone Of Inhibition, Topical Formulation, Staphylococcus Aureus, Escherichia Coli},
      month = {May},
      doi = {https://doi.org/10.64388/IREV9I11-1717485}
  }